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DrugSearchTool SIGNED

Innovative FRET-based toolkit for screening of drugs to fight miRNA-related diseases and its use in the development of cancer treatment with miRNA-96 as a therapeutic target

Total Cost €

0

EC-Contrib. €

0

Partnership

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 DrugSearchTool project word cloud

Explore the words cloud of the DrugSearchTool project. It provides you a very rough idea of what is the project "DrugSearchTool" about.

invaluable    throughput    outcome    urgent    resolution    scientific    postdoctoral    optimized    stated    universal    presentation    gothenburg    industrial    group    pancreatic    ouml    mirna    supervisor    base    fellowship    prof    professional    me    supervision    skills    capacities    gain    small    carry    dynamics    screening    advantage    molecules    regarding    position    chalmers    max    expertise    cell    assays    cancer    msca    tumor    vitro    wilhelmsson    rna    pharmaceutical    az    analogues    pioneered    structure    interaction    competences    cells    communication    training    technique    master    biochemistry    mentoring    nature    writing    fbas    photophysical    assay    critical    ttingen    full    secondments    roles    starting    toolkit    utilized    drugs    planck    interdisciplinary    university    molecule    nucleic    fluorescent    suppressing    maturity    astrazeneca    mirnas    networking    microrna    characterization    apart    globe    warsaw    reaching    ugot    interactions    industry    intersectoral    96    biological    free    fret    acid    marcus   

Project "DrugSearchTool" data sheet

The following table provides information about the project.

Coordinator		 CHALMERS TEKNISKA HOEGSKOLA AB 

Organization address
address: -
city: GOETEBORG
postcode: 41296
website: www.chalmers.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHALMERS TEKNISKA HOEGSKOLA AB SE (GOETEBORG) coordinator 185˙857.00

Map

 Project objective

The overall goal of this project is to develop a universal FRET-based toolkit for screening of drugs targeting microRNA (miRNA). Specific outcome will be a high-throughput assay for finding drugs targeting miRNA-96, a tumor-suppressing miRNA in pancreatic cancer cells. FRET is the technique of choice and recently, Prof. Marcus Wilhelmsson, Chalmers University of Technology (CHALMERS; project main supervisor) pioneered the development and photophysical characterization of fluorescent base analogues (FBAs) optimized for high-resolution FRET analysis of nucleic acid systems. There is an urgent need in pharmaceutical industry for an in vitro, cell-free, pre-miRNA-small molecule interaction high-throughput assay and also to increase the understanding of the nature of miRNAs. In this project, the unique FRET FBAs will be utilized to develop such assays and to provide new knowledge regarding miRNA structure, dynamics and interactions with other biological molecules or drugs. Apart from taking on the new research field stated above and developing my professional skills, I will bring in new competences to CHALMERS in RNA biochemistry (from the University of Warsaw and Max Planck Institute in Göttingen). Moreover, as part of my training, I will carry out research at AstraZeneca (AZ) and Gothenburg University (UGOT) through secondments. CHALMERS/AZ/UGOT have an established collaboration and I will take full advantage of their R&T capacities in order to gain interdisciplinary and intersectoral expertise as well as to master my skills in scientific communication, scientific writing, coordinating research projects, results exploitation, critical assessment, mentoring, supervision, presentation and networking with other researchers across the globe. This MSCA Postdoctoral Fellowship will help me reaching a position of professional maturity invaluable for starting up my own research group or taking leading roles in industrial R&D organizations.

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The information about "DRUGSEARCHTOOL" are provided by the European Opendata Portal: CORDIS opendata.

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