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DrugSearchTool SIGNED

Innovative FRET-based toolkit for screening of drugs to fight miRNA-related diseases and its use in the development of cancer treatment with miRNA-96 as a therapeutic target

Total Cost €

0

EC-Contrib. €

0

Partnership

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 DrugSearchTool project word cloud

Explore the words cloud of the DrugSearchTool project. It provides you a very rough idea of what is the project "DrugSearchTool" about.

communication    industry    small    cancer    drugs    acid    microrna    cells    cell    astrazeneca    urgent    industrial    pancreatic    apart    nucleic    interdisciplinary    analogues    maturity    networking    free    vitro    scientific    chalmers    universal    interactions    skills    advantage    structure    writing    rna    invaluable    secondments    biochemistry    master    carry    optimized    ouml    stated    planck    assays    critical    postdoctoral    regarding    ugot    marcus    throughput    pioneered    ttingen    characterization    max    utilized    warsaw    fret    gothenburg    dynamics    pharmaceutical    biological    base    supervision    resolution    photophysical    expertise    reaching    az    nature    96    capacities    group    supervisor    wilhelmsson    suppressing    intersectoral    screening    outcome    fluorescent    msca    tumor    assay    full    fbas    gain    mirna    roles    starting    mentoring    presentation    technique    university    globe    position    professional    training    interaction    prof    mirnas    molecule    me    toolkit    molecules    competences    fellowship   

Project "DrugSearchTool" data sheet

The following table provides information about the project.

Coordinator
CHALMERS TEKNISKA HOEGSKOLA AB 

Organization address
address: -
city: GOETEBORG
postcode: 41296
website: www.chalmers.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHALMERS TEKNISKA HOEGSKOLA AB SE (GOETEBORG) coordinator 185˙857.00

Map

 Project objective

The overall goal of this project is to develop a universal FRET-based toolkit for screening of drugs targeting microRNA (miRNA). Specific outcome will be a high-throughput assay for finding drugs targeting miRNA-96, a tumor-suppressing miRNA in pancreatic cancer cells. FRET is the technique of choice and recently, Prof. Marcus Wilhelmsson, Chalmers University of Technology (CHALMERS; project main supervisor) pioneered the development and photophysical characterization of fluorescent base analogues (FBAs) optimized for high-resolution FRET analysis of nucleic acid systems. There is an urgent need in pharmaceutical industry for an in vitro, cell-free, pre-miRNA-small molecule interaction high-throughput assay and also to increase the understanding of the nature of miRNAs. In this project, the unique FRET FBAs will be utilized to develop such assays and to provide new knowledge regarding miRNA structure, dynamics and interactions with other biological molecules or drugs. Apart from taking on the new research field stated above and developing my professional skills, I will bring in new competences to CHALMERS in RNA biochemistry (from the University of Warsaw and Max Planck Institute in Göttingen). Moreover, as part of my training, I will carry out research at AstraZeneca (AZ) and Gothenburg University (UGOT) through secondments. CHALMERS/AZ/UGOT have an established collaboration and I will take full advantage of their R&T capacities in order to gain interdisciplinary and intersectoral expertise as well as to master my skills in scientific communication, scientific writing, coordinating research projects, results exploitation, critical assessment, mentoring, supervision, presentation and networking with other researchers across the globe. This MSCA Postdoctoral Fellowship will help me reaching a position of professional maturity invaluable for starting up my own research group or taking leading roles in industrial R&D organizations.

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The information about "DRUGSEARCHTOOL" are provided by the European Opendata Portal: CORDIS opendata.

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