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DrugSearchTool SIGNED

Innovative FRET-based toolkit for screening of drugs to fight miRNA-related diseases and its use in the development of cancer treatment with miRNA-96 as a therapeutic target

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DrugSearchTool project word cloud

Explore the words cloud of the DrugSearchTool project. It provides you a very rough idea of what is the project "DrugSearchTool" about.

biochemistry    screening    position    optimized    molecules    nature    starting    drugs    chalmers    msca    maturity    interactions    suppressing    cancer    industry    max    microrna    intersectoral    throughput    interdisciplinary    utilized    ugot    free    assays    urgent    analogues    mirnas    postdoctoral    fluorescent    dynamics    advantage    supervision    prof    master    communication    ttingen    globe    carry    nucleic    wilhelmsson    pancreatic    ouml    fbas    outcome    biological    structure    expertise    molecule    cells    base    planck    secondments    reaching    industrial    gain    university    full    interaction    regarding    scientific    mirna    photophysical    roles    critical    supervisor    small    training    invaluable    cell    competences    skills    fellowship    assay    az    toolkit    technique    group    astrazeneca    pioneered    resolution    fret    gothenburg    professional    capacities    marcus    tumor    characterization    pharmaceutical    96    universal    presentation    acid    networking    warsaw    rna    writing    vitro    apart    me    stated    mentoring   

Project "DrugSearchTool" data sheet

The following table provides information about the project.

Coordinator
CHALMERS TEKNISKA HOEGSKOLA AB 

Organization address
address: -
city: GOETEBORG
postcode: 41296
website: www.chalmers.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHALMERS TEKNISKA HOEGSKOLA AB SE (GOETEBORG) coordinator 185˙857.00

Map

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 Project objective

The overall goal of this project is to develop a universal FRET-based toolkit for screening of drugs targeting microRNA (miRNA). Specific outcome will be a high-throughput assay for finding drugs targeting miRNA-96, a tumor-suppressing miRNA in pancreatic cancer cells. FRET is the technique of choice and recently, Prof. Marcus Wilhelmsson, Chalmers University of Technology (CHALMERS; project main supervisor) pioneered the development and photophysical characterization of fluorescent base analogues (FBAs) optimized for high-resolution FRET analysis of nucleic acid systems. There is an urgent need in pharmaceutical industry for an in vitro, cell-free, pre-miRNA-small molecule interaction high-throughput assay and also to increase the understanding of the nature of miRNAs. In this project, the unique FRET FBAs will be utilized to develop such assays and to provide new knowledge regarding miRNA structure, dynamics and interactions with other biological molecules or drugs. Apart from taking on the new research field stated above and developing my professional skills, I will bring in new competences to CHALMERS in RNA biochemistry (from the University of Warsaw and Max Planck Institute in Göttingen). Moreover, as part of my training, I will carry out research at AstraZeneca (AZ) and Gothenburg University (UGOT) through secondments. CHALMERS/AZ/UGOT have an established collaboration and I will take full advantage of their R&T capacities in order to gain interdisciplinary and intersectoral expertise as well as to master my skills in scientific communication, scientific writing, coordinating research projects, results exploitation, critical assessment, mentoring, supervision, presentation and networking with other researchers across the globe. This MSCA Postdoctoral Fellowship will help me reaching a position of professional maturity invaluable for starting up my own research group or taking leading roles in industrial R&D organizations.

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The information about "DRUGSEARCHTOOL" are provided by the European Opendata Portal: CORDIS opendata.

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