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Deep brain targets for neurostimulation in affective disorders

Total Cost €


EC-Contrib. €






Project "Debrasa" data sheet

The following table provides information about the project.


Organization address
city: GENEVE
postcode: 1211

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE CH (GENEVE) coordinator 187˙419.00


 Project objective

Objective: The overarching goal of proposed project is to provide necessary knowledge about neurobiology of Major Depression Disorder (MDD), which would lead to higher efficacy in treatment of this affective disorder. The research objectives of the action are 1) identification of electrophysiological biomarkers of functional brain abnormities in treatment resistant depression (TRD) and 2) suggestion of novel targets for neurostimulation in patients with TRD. Methods: Twenty patients with major Depression Disorder (MDD) and 20 healthy controls will undergo a resting-state high-density EEG recording (HD-EEG). Microstate analysis will be performed to identify possible biomarkers of functional brain abnormity in MDD. Source activity will be obtained for regions of interest (ROI) using individual head model and a distributed linear inverse solution. Directed functional connectivity using Granger causal modelling will be applied to the source signals of ROI to identify abnormally interconnected nodes. Relevance: If new biomarkers of functional brain abnormity in MDD are identified, better characterisation of pathophysiology of depression will be made. If abnormal nodes of large-scale brain neuronal network are identified, new and individually specific targets for deep brain stimulation (DBS) will be suggested. These findings will support future implementation of highly individualised DBS treatment of TRD.


year authors and title journal last update
List of publications.
2020 Alena Damborská, Eliška Honzírková, Richard Barteček, Jana Hořínková, Sylvie Fedorová, Šimon Ondruš, Christoph M. Michel, Maria Rubega
Altered directed functional connectivity of the right amygdala in depression: high-density EEG study
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-61264-z
Scientific Reports 10/1 2020-03-24
2019 Alena Damborská, Camille Piguet, Jean-Michel Aubry, Alexandre G. Dayer, Christoph M. Michel, Cristina Berchio
Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients
published pages: , ISSN: 1664-0640, DOI: 10.3389/fpsyt.2019.00826
Frontiers in Psychiatry 10 2019-11-22
2019 Dominik Drobisz, Alena Damborská
Deep brain stimulation targets for treating depression
published pages: 266-273, ISSN: 0166-4328, DOI: 10.1016/j.bbr.2018.11.004
Behavioural Brain Research 359 2019-09-25
2019 Alena Damborská, Miralena I. Tomescu, Eliška Honzírková, Richard Barteček, Jana Hořínková, Sylvie Fedorová, Šimon Ondruš, Christoph M. Michel
EEG Resting-State Large-Scale Brain Network Dynamics Are Related to Depressive Symptoms
published pages: , ISSN: 1664-0640, DOI: 10.3389/fpsyt.2019.00548
Frontiers in Psychiatry 10 2019-09-25

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