Cynthetica
Development of tools to increase product yields in cyanobacteria using a synthetic biology approach
Total Cost €
0EC-Contrib. €
0Partnership
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0Cynthetica project word cloud
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Project "Cynthetica" data sheet
The following table provides information about the project.
| Coordinator |
KOBENHAVNS UNIVERSITET
Organization address contact info |
| Coordinator Country | Denmark [DK] |
| Project website | https://plen.ku.dk/english/employees/ |
| Total cost | 200˙194 € |
| EC max contribution | 200˙194 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-06-01 to 2019-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KOBENHAVNS UNIVERSITET | DK (KOBENHAVN) | coordinator | 200˙194.00 |
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Project objective
Cyanobacteria are versatile photosynthetic organisms that have attracted interest as a sustainable biotechnological host chassis. The toolkit for these organisms is growing fast, however, limitations such as low productivities are still a major drawback for this emerging technology. Cynthetica will address the issue of recombinant product yields and develop two separate tools that can be universally applied for product synthesis in cyanobacteria. WP1 incorporates the development of an ‘anchor tool’ to increase stability and the interaction of membrane-bound recombinant enzymes, such as cytochrome P450s, in cyanobacterial thylakoid membranes via membrane anchor engineering. This will lead to improved metabolic fluxes through the pathway and, thus, higher product yields. In WP2 a ‘capsule tool’ will be developed. Cyanobacterial strains with proteinaceous shells, so-called microcompartments, will be generated to encapsulate biosynthetic pathways for improved product yields. In WP3 the Cynthetica tools will be tested at scale for their applicability in an industrial setting during a secondment with the partner organisation AGROT. The intersectoral knowledge transfer between UCPH, AGROT and the fellow will allow for timely progression of the project, delivering cutting edge science and allowing the fellow to grow not only her scientific skill set but also reach maturity as an academic researcher. Thanks to the state-of-the art equipment and expertise available at UCPH and AGROT the project will have most favourable conditions to be a success. The Horizon 2020 framework highlights the need to develop a sustainable biotechnology sector in Europe. Cynthetica will position itself at the forefront of this emerging field by delivering innovative synthetic biology tools for establishing cyanobacteria as a powerful photosynthetic production platform.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
David A Russo, Julie A Z Zedler, Poul Erik Jensen A force awakens: exploiting solar energy beyond photosynthesis published pages: 1703-1710, ISSN: 0022-0957, DOI: 10.1093/jxb/erz054 |
Journal of Experimental Botany 70/6 | 2019-09-25 |
| 2019 |
D. A. Russo, J. A. Z. Zedler, D. N. Wittmann, B. Möllers, R. K. Singh, T. S. Batth, B. van Oort, J. V. Olsen, M. J. Bjerrum, P. E. Jensen Expression and secretion of a lytic polysaccharide monooxygenase by a fast-growing cyanobacterium published pages: , ISSN: 1754-6834, DOI: 10.1186/s13068-019-1416-9 |
Biotechnology for Biofuels 12/1 | 2019-09-25 |
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