Explore the words cloud of the AntibioPICs project. It provides you a very rough idea of what is the project "AntibioPICs" about.
The following table provides information about the project.
THE UNIVERSITY OF BIRMINGHAM
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-03-12 to 2020-05-31|
Take a look of project's partnership.
|1||THE UNIVERSITY OF BIRMINGHAM||UK (BIRMINGHAM)||coordinator||195˙454.00|
Here, we will develop new enzyme-degradable polymers for the preparation of polyion complex (PIC) particles based of antimicrobial molecules with low charge densities. The main goals are:
1. Synthesis of enzyme-responsive polymers, with a) enough charge density to facilitate PIC particle formation, and b) degradable by Pseudolysin, a protease secreted by opportunistic bacteria Pseudomonas aeruginosa; 2. Preparation of Pseudolysin-Degradable PIC Particles, from these enzyme responsive polymers and 1) Polymyxin B (PolB), an antimicrobial peptide with only 5 cationic charges; or 2) FM® 1-43 Dye, a cationic membrane dye that stains gram-negative bacteria; 3. Characterisation of PIC particle stability and enzyme-degradation kinetics and selectivity, and 4. In-vitro evaluation of 1) the antimicrobial activity against P. aeruginosa of PolB-containing particles and 2) the ability of FM-containing particles to stain P. aeruginosa.
Completion of these goals will allow us to demonstrate that: a) Polymers with high charge densities can be prepared based on short peptides; that b) stable PIC particles can be prepared from relevant small molecules; despite the challenges posed by their low charge density; that c) the stability and release profile of these biologically active molecules can be tuned as a function of polymer composition and particle formulation; and that d) PIC particles are promising vectors for the delivery of antimicrobial molecules.
The main scientific challenge lies in the development of the proposed materials, but the molecules to be delivered have been selected because of their relevance to antimicrobial resistance, one of the research priorities of the European Commission. Each exemplar will contribute to address complementary problems: 1) the development of better methods to use currently available antibiotics (PolB) and 2) the early detection of pathogenic strains (FM).
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ANTIBIOPICS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "ANTIBIOPICS" are provided by the European Opendata Portal: CORDIS opendata.
Cholinergic and NMDAR-dependent recruitment of Layer 1 Interneuron shapes cortical motor Processing through network States ModulationRead More
New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling.Read More
The missing pillar. European social policy and Eurosceptic challenges (SOCIALEU)Read More