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DRYSTORE

Exploring dry storage as an alternative biobanking strategy inspired by Nature

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DRYSTORE project word cloud

Explore the words cloud of the DRYSTORE project. It provides you a very rough idea of what is the project "DRYSTORE" about.

cells    communication    liquid    solid    perfect    drying    attractive    protect    students    maintained    scientific    date    fast    searching    crossing    combining    monitoring    efficiency    background    industry    nuclear    protocol    advantage    function    mutual    researcher    nitrogen    nature    andrology    profile    biology    competitive    preservation    audiences    genetic    expert    genomic    freezing    participating    public    global    epi    definitive    stepping    latest    drawbacks    sperm    elucidate    model    laboratory    host    facilities    technologies    policymakers    structure    stone    interdisciplinary    carbon    embryology    conferences    creative    scnt    supply    footprint    mentoring    communicating    discovery    stability    fibroblast    epigenetic    outcomes    trained    scientist    mammalian    dna    alternatives    stakeholders    biobanking    scientists    learning    cell    desiccation    independent    genome    satisfactory    continuous    techniques    survive    cryobiology    benefit    ln    data    expertise    creates    somatic    skills    expensive    transfer    supervisor    load   

Project "DRYSTORE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TERAMO 

Organization address
address: VIA RENATO BALZARINI 1 3 5 7
city: TERAMO
postcode: 64100
website: www.unite.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://drystore.unite.it
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TERAMO IT (TERAMO) coordinator 180˙277.00

Map

 Project objective

Biobanking under liquid nitrogen (LN) has satisfactory efficiency but it comes with many drawbacks (e.g. expensive, high carbon footprint, need dedicated facilities, trained personnel, and continuous monitoring and LN supply). Searching Nature for alternatives, long-term preservation there is done by drying rather than freezing. To date, however, mammalian cells do not survive the drying process. Even so, if somatic cells genetic and epigenetic load is maintained, drying can find an important role in biobanking, a fast growing global industry. We aim to elucidate the effects of drying on DNA structure and function, crucial aspects of long-term biobanking not investigated yet, using fibroblast as a model cell, and combining advanced freezing and drying techniques with state-of-the-art Somatic Cell Nuclear Transfer (SCNT) and latest genomic technologies. The expected outcomes are definitive data on effects of drying on genomic stability/function, and possible discovery of a protocol to protect the epi/genetic load during cell drying. The crossing between the Researcher’s scientific interest and experience in sperm biology, andrology, cryobiology and drying and the Supervisor’s expertise in embryology and SCNT creates an attractive and very solid background for this proposal, with mutual benefit to both Host and Researcher. While strengthening the Supervisor’s laboratory with his expertise, the Researcher will enhance his creative potential and further develop his interdisciplinary and communication skills by learning SCNT and whole genome analysis as well as mentoring students, participating in conferences, and communicating research results to targeted audiences (scientists, general public, students, stakeholders, policymakers), thus enhancing his scientific profile. This proposal is the perfect stepping stone for the Researcher to become an independent scientist and an expert in desiccation for biobanking, while contributing a competitive advantage to the Host.

 Publications

year authors and title journal last update
List of publications.
2018 Luca PALAZZESE, Jaime GOSÁLVEZ, Debora A. ANZALONE, Pasqualino LOI, Joseph SARAGUSTY
DNA fragmentation in epididymal freeze-dried ram spermatozoa impairs embryo development
published pages: 393-400, ISSN: 0916-8818, DOI: 10.1262/jrd.2018-033
Journal of Reproduction and Development 64/5 2020-01-27
2019 Joseph Saragusty, Pasqualino Loi
Exploring dry storage as an alternative biobanking strategy inspired by Nature
published pages: 17-27, ISSN: 0093-691X, DOI: 10.1016/j.theriogenology.2018.11.027
Theriogenology 126 2020-01-27

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