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DRYSTORE

Exploring dry storage as an alternative biobanking strategy inspired by Nature

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DRYSTORE project word cloud

Explore the words cloud of the DRYSTORE project. It provides you a very rough idea of what is the project "DRYSTORE" about.

definitive    profile    cells    host    outcomes    epigenetic    attractive    communicating    searching    genetic    mutual    ln    participating    stepping    trained    freezing    nature    desiccation    combining    efficiency    cell    satisfactory    expensive    researcher    continuous    creates    solid    genome    genomic    global    protect    stability    independent    students    scientist    sperm    liquid    latest    monitoring    audiences    benefit    facilities    data    learning    scnt    fibroblast    date    skills    perfect    background    maintained    advantage    drawbacks    biology    dna    supervisor    competitive    scientists    nitrogen    function    somatic    public    embryology    expert    drying    mentoring    stakeholders    technologies    carbon    cryobiology    stone    transfer    industry    mammalian    alternatives    footprint    creative    discovery    fast    structure    preservation    interdisciplinary    crossing    supply    protocol    andrology    model    policymakers    laboratory    biobanking    elucidate    techniques    load    conferences    epi    communication    scientific    expertise    survive    nuclear   

Project "DRYSTORE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TERAMO 

Organization address
address: VIA RENATO BALZARINI 1 3 5 7
city: TERAMO
postcode: 64100
website: www.unite.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://drystore.unite.it
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TERAMO IT (TERAMO) coordinator 180˙277.00

Map

 Project objective

Biobanking under liquid nitrogen (LN) has satisfactory efficiency but it comes with many drawbacks (e.g. expensive, high carbon footprint, need dedicated facilities, trained personnel, and continuous monitoring and LN supply). Searching Nature for alternatives, long-term preservation there is done by drying rather than freezing. To date, however, mammalian cells do not survive the drying process. Even so, if somatic cells genetic and epigenetic load is maintained, drying can find an important role in biobanking, a fast growing global industry. We aim to elucidate the effects of drying on DNA structure and function, crucial aspects of long-term biobanking not investigated yet, using fibroblast as a model cell, and combining advanced freezing and drying techniques with state-of-the-art Somatic Cell Nuclear Transfer (SCNT) and latest genomic technologies. The expected outcomes are definitive data on effects of drying on genomic stability/function, and possible discovery of a protocol to protect the epi/genetic load during cell drying. The crossing between the Researcher’s scientific interest and experience in sperm biology, andrology, cryobiology and drying and the Supervisor’s expertise in embryology and SCNT creates an attractive and very solid background for this proposal, with mutual benefit to both Host and Researcher. While strengthening the Supervisor’s laboratory with his expertise, the Researcher will enhance his creative potential and further develop his interdisciplinary and communication skills by learning SCNT and whole genome analysis as well as mentoring students, participating in conferences, and communicating research results to targeted audiences (scientists, general public, students, stakeholders, policymakers), thus enhancing his scientific profile. This proposal is the perfect stepping stone for the Researcher to become an independent scientist and an expert in desiccation for biobanking, while contributing a competitive advantage to the Host.

 Publications

year authors and title journal last update
List of publications.
2018 Luca PALAZZESE, Jaime GOSÁLVEZ, Debora A. ANZALONE, Pasqualino LOI, Joseph SARAGUSTY
DNA fragmentation in epididymal freeze-dried ram spermatozoa impairs embryo development
published pages: 393-400, ISSN: 0916-8818, DOI: 10.1262/jrd.2018-033
Journal of Reproduction and Development 64/5 2020-01-27
2019 Joseph Saragusty, Pasqualino Loi
Exploring dry storage as an alternative biobanking strategy inspired by Nature
published pages: 17-27, ISSN: 0093-691X, DOI: 10.1016/j.theriogenology.2018.11.027
Theriogenology 126 2020-01-27

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