Opendata, web and dolomites

TransTempoFold SIGNED

A need for speed: mechanisms to coordinate protein synthesis and folding in metazoans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TransTempoFold project word cloud

Explore the words cloud of the TransTempoFold project. It provides you a very rough idea of what is the project "TransTempoFold" about.

powerful    translation    screens    shapes    human    modulate    progeny    misfolded    trnas    individual    rely    stem    interplay    model    maintained    biogenesis    ribosome    types    mrna    normal    regulatory    homeostasis    tolerate    dissect    damage    detrimental    lines    centred    synthesis    mechanism    neuronal    aging    created    imbalanced    protein    folding    cellular    vivo    supply    pluripotent    metazoan    quantitate    regulators    cell    unknown    networks    depletion    systematic    multiscale    function    intricate    defects    profiling    uncover    codon    specialized    expression    differentiation    first    patterns    proteome    tissues    vulnerable    sequence    integrity    conformation    isogenic    reveal    cardiac    pools    structure    lineages    metazoans    proteomes    dynamics    conserved    quality    trna    abundance    speed    differentiated    diseases    fold    dimensional    proteins    health    begin    modulating    diverse    evolutionarily    hallmark    identity    explore    cells   

Project "TransTempoFold" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙500˙000.00

Map

 Project objective

Proteins function only after folding into complex three-dimensional shapes. Loss of protein conformation is detrimental for cellular health, and a hallmark of aging and diverse human diseases. To ensure proteome integrity, cells rely on an intricate interplay between protein synthesis, folding, and quality control. Since proteins often begin to fold during mRNA translation, codon choice and tRNA supply can promote this process by modulating translation speed. How metazoans exploit this mechanism to ensure protein homeostasis over a wide range of cells and tissues, or why some cell types are more vulnerable to translation defects and proteome damage remains unknown. Here, I will define how tRNA pools and the regulatory networks for protein biogenesis and homeostasis are tailored to specialized proteomes in different cell types. I propose a multiscale systems approach centred around: i) stem cells and differentiated progeny lines as a powerful model system, and ii) a novel method to modulate cellular tRNA pools in vivo. Isogenic lines of a range of normal cellular states will be created through the differentiation of human pluripotent stem cells into neuronal and cardiac lineages. In these lineages, I will first quantitate tRNA expression and abundance, and dissect their impact on translation dynamics with ribosome profiling. Second, I will use systematic depletion of individual tRNAs to explore how different cell types respond to imbalanced tRNA pools, and define how mRNA sequence and protein structure patterns program protein folding. Third, I will use loss-of-function screens to uncover evolutionarily conserved regulators of proteome integrity as a function of cell identity. This project will define how diverse metazoan cell proteomes are established and maintained, and reveal why some cells tolerate misfolded proteins better than others.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRANSTEMPOFOLD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TRANSTEMPOFOLD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SWIP (2019)

Extended short-wave infrared pulsed fibre laser

Read More  

CerQuS (2019)

Certified Quantum Security

Read More  

MOCHA (2019)

Understanding and leveraging ‘moments of change’ for pro-environmental behaviour shifts

Read More