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SINMOF

Synthesis of Spirooxindoles and INdoles pharmaceuticals using Metal-Organic Frameworks

Total Cost €

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EC-Contrib. €

0

Partnership

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 SINMOF project word cloud

Explore the words cloud of the SINMOF project. It provides you a very rough idea of what is the project "SINMOF" about.

expertise    manner    site    spirooxindole    introduction    synthesis    immobilised    occurring    active    completing    mof    secondment    employing    fluorescence    comprehensively    anticancerigen    researcher    fellow    pharmaceuticals    mutually    internal    framework    indole    mofs    generation    catalysts    scales    deactivation    stage    derive    selective    methodology    smallest    heterogeneous    sumatriptan    highest    catalyst    sar405838    metal    center    beneficial    homogeneous    respect    structured    ultrastable    collaborations    core    losses    relationships    host    sites    sinmof    isolation    synthetic    microscopy    solids    isolated    successfully    industry    individuate    underlying    resistant    environmentally    molecular    employed    pharmaceutical    train    insights    porous    self    stable    multifunctional    neurotransmitter    catalytic    chance    world    structure    materials    economically    convenient    pioneering    organic    overcome    selectivity    model    hybrid    effort    ensures    catalysis    translated    mechanisms    combined    length    strategies    compounds    sensitivities    pharmaceutically    solid   

Project "SINMOF" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://sinmof.blogspot.com/
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 160˙800.00

Map

 Project objective

SINMOF is a pioneering and structured effort to comprehensively address the introduction of different immobilised isolated catalytic active sites in solid hybrid materials to overcome the metal losses occurring with state-of-the-art homogeneous catalysts employed in the pharmaceutical industry. The convenient use of hybrid metal-organic framework materials (MOFs) respect to traditional state-of-the-art porous solid materials is due to (a) self-deactivation-resistant design of the active sites by (b) ultrastable catalytic site isolation. In the SINMOF project we will (1) design novel multifunctional MOFs as next generation catalysts for the synthesis of pharmaceutically active compounds in an economically and environmentally beneficial way; (2) apply MOF hybrid solids as heterogeneous catalysts to avoid the use of homogeneous metal catalysts in novel synthetic strategies of pharmaceuticals with the indole core and finally (3) derive structure-activity and selectivity relationships at the smallest possible length scales and with the highest possible sensitivities employing fluorescence microscopy. Using a two-stage research methodology, SINMOF will finally provide the most active and stable MOF catalyst for the synthesis of the indole-based neurotransmitter Sumatriptan and the anticancerigen spirooxindole SAR405838. The combined expertise of the fellow and host ensures the best chance for successfully completing the SINMOF objectives in a mutually beneficial manner. On one side, internal collaborations at the host institution will allow the access to state-of-the-art fluorescence microscopy methods, to get new insights into the molecular mechanisms underlying the novel catalytic systems. On the other side, a secondment at a world-leading research center in the homogeneous catalysis field will train the researcher in order to individuate the best molecular features for model homogeneous catalysts to be translated into selective heterogeneous MOF catalytic system.

 Publications

year authors and title journal last update
List of publications.
2018 Cédric Van Goethem, Matthias Mertens, Francisco G. Cirujano, Jin W. Seo, Dirk De Vos, Ivo F. J. Vankelecom
Improved MOF nanoparticle recovery and purification using crosslinked PVDF membranes
published pages: 7370-7373, ISSN: 1359-7345, DOI: 10.1039/c8cc04326d
Chemical Communications 54/53 2020-01-21
2019 Chunmei Jia, Francisco G. Cirujano, Bart Bueken, Birgit Claes, Dries Jonckheere, Kevin M. Van Geem, Dirk De Vos
Geminal Coordinatively Unsaturated Sites on MOF‐808 for the Selective Uptake of Phenolics from a Real Bio‐Oil Mixture
published pages: 1256-1266, ISSN: 1864-5631, DOI: 10.1002/cssc.201802692
ChemSusChem 12/6 2020-01-21
2019 Chunmei Jia, Bart Bueken, Francisco G. Cirujano, Kevin M. Van Geem, Dirk De Vos
Phenolics isolation from bio-oil using the metal–organic framework MIL-53(Al) as a highly selective adsorbent
published pages: 6245-6248, ISSN: 1359-7345, DOI: 10.1039/c9cc02177a
Chemical Communications 55/44 2020-01-21
2017 Maxime Stalpaert, Francisco G. Cirujano, Dirk E. De Vos
Tetrabutylphosphonium Bromide Catalyzed Dehydration of Diols to Dienes and Its Application in the Biobased Production of Butadiene
published pages: 5802-5809, ISSN: 2155-5435, DOI: 10.1021/acscatal.7b01765
ACS Catalysis 7/9 2020-01-21
2019 Carlos Marquez, Francisco G. Cirujano, Simon Smolders, Cédric Van Goethem, Ivo Vankelecom, Dirk De Vos, Trees De Baerdemaeker
Metal ion exchange in Prussian blue analogues: Cu( ii )-exchanged Zn–Co PBAs as highly selective catalysts for A 3 coupling
published pages: 3946-3954, ISSN: 1477-9226, DOI: 10.1039/c9dt00388f
Dalton Transactions 48/12 2020-01-21
2018 Carlos Marquez, Francisco G. Cirujano, Cédric Van Goethem, Ivo Vankelecom, Dirk De Vos, Trees De Baerdemaeker
Tunable Prussian blue analogues for the selective synthesis of propargylamines through A 3 coupling
published pages: 2061-2065, ISSN: 2044-4753, DOI: 10.1039/c8cy00073e
Catalysis Science & Technology 8/8 2020-01-21
2017 Francisco G Cirujano, Elena López‐Maya, Marleny Rodríguez‐Albelo, Elisa Barea, Jorge AR Navarro, Dirk E De Vos
Selective One‐Pot Two‐Step C− C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts
published pages: , ISSN: 1867-3899, DOI:
chemcatchem 2020-01-21
2017 FG Cirujano
MOFs vs. zeolites: carbonyl activation with M (IV) catalytic sites
published pages: , ISSN: 2044-4761, DOI:
Catalysis Science & Technology 2020-01-21
2017 Francisco G Cirujano, Ignacio Luz, Mustapha Soukri, Cedric Van Goethem, Ivo FJ Vankelecom, Marty Lail, Dirk E De Vos
Boosting the catalytic performance of metal–organic frameworks for steroid transformations by confinement within a mesoporous scaffold
published pages: , ISSN: 1521-3773, DOI:
Angewandte Chemie Int Ed 2020-01-21
2018 Francisco G Cirujano, Maxime Stalpaert, Dirk E De Vos
Ionic liquids vs. microporous solids as reusable reaction media for the catalytic C–H functionalization of indoles with alcohols
published pages: , ISSN: 1463-9270, DOI:
Green chemistry 2020-01-21
2018 Francisco G Cirujano, Elena López-Maya, JAR Navarro, Dirk E De Vos
Pd (II)–Ni (II) Pyrazolate Framework as Active and Recyclable Catalyst for the Hydroamination of Terminal Alkynes
published pages: , ISSN: 1022-5528, DOI:
Topics in Catalysis 2020-01-21
2019 F G Cirujano
Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients
published pages: , ISSN: 1867-3899, DOI:
chemcatchem 2020-01-21
2018 Francisco G Cirujano, Pedro Leo, Jannick Vercammen, Simon Smolders, Gisela Orcajo, Dirk E De Vos
MOFs Extend the Lifetime of Pd (II) Catalyst for Room Temperature Alkenylation of Enamine‐Like Arenes
published pages: , ISSN: 1615-4169, DOI:
Advanced Synthesis & Catalysis 2020-01-21
2019 Nuria Martin, Michiel Dusselier, Dirk E De Vos, Francisco G Cirujano
Metal-Organic Framework Derived Metal Oxide Clusters in Porous Aluminosilicates: A Catalyst Design for the Synthesis of Bioactive aza-Heterocycles
published pages: , ISSN: 2155-5435, DOI:
ACS Catalysi 2020-01-21

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