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MArylAND SIGNED

At the host-bacteria interface: Modulation of the intestinal microbiota and its metabolic activity by Card9 signalling in health and Inflammatory Bowel Diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MArylAND project word cloud

Explore the words cloud of the MArylAND project. It provides you a very rough idea of what is the project "MArylAND" about.

receptor    impaired    disease    individuals    incidence    fragile    network    card9    techniques    always    intestine    gut    caspase    metabolites    acquire    health    community    colitis    lives    transcriptomics    mirrors    integrative    edge    skills    metabolomics    bowel    preventive    ligands    purpose    receptors    ecosystem    animals    genetic    humans    expand    host    cutting    microorganisms    ahr    decipher    protein    colleagues    fungi    cell    strengthen    environment    plan    bacteria    lox    mice    influences    gnotobiotic    immunosuppressive    tryptophan    treatments    innovative    nutrition    deciphering    codes    therapeutic    domain    sokol    aryl    recruitment    conceptual    mechanisms    scientific    environmental    microbial    altered    metabolic    alteration    exhibit    collaborative    inflammatory    advantage    patients    balance    types    combination    genotype    predisposition    seem    crosstalk    microbiota    interface    me    activating    showed    biology    modulation    hydrocarbon    ibd    pathologies    genes    strategies    human    cre    susceptibility    metabolise   

Project "MArylAND" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2020-02-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 185˙076.00

Map

 Project objective

The microbial community in the human intestine is crucial to the health and nutrition of the host. Loss of the fragile balance within this complex ecosystem is involved in numerous pathologies, including inflammatory bowel disease (IBD). The incidence of IBD is increasing and affects individuals in challenging years of their lives, with immunosuppressive treatments that are not always effective. IBD results from a combination of genetic predisposition, alteration of the gut microbiota, and environmental influences. Thus, deciphering the host-bacteria crosstalk will improve our understanding of IBD and enable new preventive and therapeutic strategies. Caspase recruitment domain 9 (Card9), one of the IBD susceptibility genes, codes for a protein involved in the response to fungi and bacteria. Sokol and colleagues showed that Card9-/- mice have an increased susceptibility to colitis, due to an altered gut microbiota that is not able to metabolise tryptophan into aryl hydrocarbon receptor (AhR) ligands. In humans, comparable mechanisms seem to be involved, as microbiota of IBD patients exhibit impaired production of AhR ligands, which mirrors the Card9-/- genotype. We aim to decipher the mechanisms involved in the modulation of the microbiota and its metabolic activity by Card9. For this purpose, we will take advantage of a strong collaborative environment and cutting-edge techniques, including gnotobiotic animals, cre-lox technology, transcriptomics, metabolomics and systems biology. Specifically, we plan to identify (i) new pathways and cell types involved in the modulation of the microbiota and its metabolic activity, and (ii) microorganisms and metabolites activating AhR receptors in the gut. This highly innovative and integrative project will allow me to expand my conceptual and technical knowledge of the gut-microbiota interface, acquire new key skills and strengthen my scientific network.

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The information about "MARYLAND" are provided by the European Opendata Portal: CORDIS opendata.

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