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MArylAND SIGNED

At the host-bacteria interface: Modulation of the intestinal microbiota and its metabolic activity by Card9 signalling in health and Inflammatory Bowel Diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MArylAND project word cloud

Explore the words cloud of the MArylAND project. It provides you a very rough idea of what is the project "MArylAND" about.

receptor    impaired    me    receptors    community    nutrition    card9    scientific    mirrors    genetic    bowel    techniques    protein    colitis    sokol    microbiota    conceptual    intestine    interface    metabolise    microbial    health    hydrocarbon    decipher    influences    showed    collaborative    patients    environmental    integrative    domain    edge    metabolomics    strengthen    humans    cell    altered    activating    cre    predisposition    environment    deciphering    tryptophan    gut    always    expand    genes    disease    caspase    ibd    metabolic    strategies    combination    fungi    seem    inflammatory    individuals    transcriptomics    fragile    crosstalk    lox    therapeutic    alteration    host    skills    mechanisms    acquire    immunosuppressive    ecosystem    incidence    biology    modulation    exhibit    balance    pathologies    human    preventive    cutting    types    bacteria    innovative    plan    animals    lives    genotype    advantage    purpose    mice    aryl    codes    network    treatments    colleagues    ahr    gnotobiotic    metabolites    susceptibility    microorganisms    ligands    recruitment   

Project "MArylAND" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2020-02-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 185˙076.00

Map

 Project objective

The microbial community in the human intestine is crucial to the health and nutrition of the host. Loss of the fragile balance within this complex ecosystem is involved in numerous pathologies, including inflammatory bowel disease (IBD). The incidence of IBD is increasing and affects individuals in challenging years of their lives, with immunosuppressive treatments that are not always effective. IBD results from a combination of genetic predisposition, alteration of the gut microbiota, and environmental influences. Thus, deciphering the host-bacteria crosstalk will improve our understanding of IBD and enable new preventive and therapeutic strategies. Caspase recruitment domain 9 (Card9), one of the IBD susceptibility genes, codes for a protein involved in the response to fungi and bacteria. Sokol and colleagues showed that Card9-/- mice have an increased susceptibility to colitis, due to an altered gut microbiota that is not able to metabolise tryptophan into aryl hydrocarbon receptor (AhR) ligands. In humans, comparable mechanisms seem to be involved, as microbiota of IBD patients exhibit impaired production of AhR ligands, which mirrors the Card9-/- genotype. We aim to decipher the mechanisms involved in the modulation of the microbiota and its metabolic activity by Card9. For this purpose, we will take advantage of a strong collaborative environment and cutting-edge techniques, including gnotobiotic animals, cre-lox technology, transcriptomics, metabolomics and systems biology. Specifically, we plan to identify (i) new pathways and cell types involved in the modulation of the microbiota and its metabolic activity, and (ii) microorganisms and metabolites activating AhR receptors in the gut. This highly innovative and integrative project will allow me to expand my conceptual and technical knowledge of the gut-microbiota interface, acquire new key skills and strengthen my scientific network.

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The information about "MARYLAND" are provided by the European Opendata Portal: CORDIS opendata.

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