Opendata, web and dolomites

MArylAND SIGNED

At the host-bacteria interface: Modulation of the intestinal microbiota and its metabolic activity by Card9 signalling in health and Inflammatory Bowel Diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MArylAND project word cloud

Explore the words cloud of the MArylAND project. It provides you a very rough idea of what is the project "MArylAND" about.

receptor    me    mice    host    always    bacteria    metabolites    aryl    cre    types    community    disease    microbial    advantage    ligands    collaborative    individuals    human    caspase    decipher    predisposition    biology    expand    combination    receptors    transcriptomics    incidence    microorganisms    humans    animals    integrative    bowel    exhibit    environment    ahr    activating    deciphering    mechanisms    balance    purpose    genetic    gut    metabolic    techniques    card9    intestine    strengthen    interface    conceptual    influences    therapeutic    altered    codes    domain    nutrition    colleagues    genotype    innovative    health    genes    protein    microbiota    sokol    alteration    inflammatory    environmental    treatments    preventive    patients    crosstalk    ecosystem    acquire    network    tryptophan    modulation    fragile    scientific    colitis    susceptibility    gnotobiotic    immunosuppressive    mirrors    hydrocarbon    cell    lox    plan    seem    edge    showed    ibd    strategies    pathologies    cutting    lives    metabolomics    fungi    recruitment    skills    metabolise    impaired   

Project "MArylAND" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2020-02-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 185˙076.00

Map

 Project objective

The microbial community in the human intestine is crucial to the health and nutrition of the host. Loss of the fragile balance within this complex ecosystem is involved in numerous pathologies, including inflammatory bowel disease (IBD). The incidence of IBD is increasing and affects individuals in challenging years of their lives, with immunosuppressive treatments that are not always effective. IBD results from a combination of genetic predisposition, alteration of the gut microbiota, and environmental influences. Thus, deciphering the host-bacteria crosstalk will improve our understanding of IBD and enable new preventive and therapeutic strategies. Caspase recruitment domain 9 (Card9), one of the IBD susceptibility genes, codes for a protein involved in the response to fungi and bacteria. Sokol and colleagues showed that Card9-/- mice have an increased susceptibility to colitis, due to an altered gut microbiota that is not able to metabolise tryptophan into aryl hydrocarbon receptor (AhR) ligands. In humans, comparable mechanisms seem to be involved, as microbiota of IBD patients exhibit impaired production of AhR ligands, which mirrors the Card9-/- genotype. We aim to decipher the mechanisms involved in the modulation of the microbiota and its metabolic activity by Card9. For this purpose, we will take advantage of a strong collaborative environment and cutting-edge techniques, including gnotobiotic animals, cre-lox technology, transcriptomics, metabolomics and systems biology. Specifically, we plan to identify (i) new pathways and cell types involved in the modulation of the microbiota and its metabolic activity, and (ii) microorganisms and metabolites activating AhR receptors in the gut. This highly innovative and integrative project will allow me to expand my conceptual and technical knowledge of the gut-microbiota interface, acquire new key skills and strengthen my scientific network.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MARYLAND" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MARYLAND" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

SmartSAST (2020)

Non-covalent photoresponsive tags for photoacoustic imaging: Giving voice to living matter

Read More  

MBL-Fermions (2020)

Probing many-body localization dynamics using ultracold fermions in an optical lattice

Read More  

PARTOWNEU (2019)

The dark side of partial ownership and financial investment in Europe: What price to pay for consumers and society?

Read More