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TransReg SIGNED

Transgenerational epigenetic inheritance of cardiac regenerative capacity in the zebrafish

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TransReg project word cloud

Explore the words cloud of the TransReg project. It provides you a very rough idea of what is the project "TransReg" about.

parents    environment    unravel    starvation    suffered    ventricular    cardiac    genetic    gene    equally    cell    injury    histone    paradigm    regenerative    progenitors    disease    describe    constitute    leads    epigenetic    ultimately    experiences    influence    sequence    regeneration    offspring    revealed    liver    heart    tei    regenerate    rats    fish    cardiomyocyte    transfer    parental    fibrosis    zebrafish    sperm    transmitted    gametes    underlying    models    play    subpopulations    humans    model    hearts    injured    origins    reveal    toxicants    shift    describes    similarly    inheritance    capacity    degree    exposed    grandparents    metabolism    regulatory    network    injuries    while    dna    generation    transgenerational    independent    suggested    adverse    cardiovascular    plasticity    myocardial    first    effect    rnas    hepatic    altered    analyze    pivotal    mechanism    regenerated    modifications    remodeling    priming    elucidated    reconstruction    grandchildren    coding    methylation    organ    causing    animals    basis    infarction    time    elicits    functional    starting   

Project "TransReg" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙999˙125 €
 EC max contribution 1˙999˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 1˙672˙875.00
2    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) participant 326˙250.00

Map

 Project objective

While myocardial infarction leads to adverse ventricular remodeling ultimately causing heart failure in humans, some animals, including zebrafish can regenerate the injured heart. We recently revealed a high degree of plasticity in cardiomyocyte subpopulations involved in the reconstruction of the injured heart. The gene regulatory network involved in heart regeneration is starting to be elucidated and epigenetic remodeling has been suggested to play a pivotal role during this process. Similarly it is known that the environment can influence the regenerative capacity but whether such an effect can be transmitted from one generation to the next has not been addressed. This mechanism is called transgenerational epigenetic inheritance (TEI) and describes the transfer of experiences from parents to their offspring through the gametes, independent on changes in DNA sequence. TEI has also been described in humans: starvation suffered by grandparents affects the metabolism of grandchildren. TEI is also relevant to organ injury: in rats, offspring from parents exposed to liver toxicants revealed reduced hepatic fibrosis in response to the same injury. Changes in DNA methylation, histone modifications and non-coding RNAs have been associated to TEI. We aim to describe for the first time epigenetic inheritance of organ regeneration and unravel its underlying mechanism using the zebrafish model. We will assess whether cardiac injury elicits epigenetic modifications in sperm and determine if offspring from injured parental fish reveal altered heart regeneration. Genetic models will be developed for functional assessment of identified modifications. We will also further analyze cell plasticity during heart regeneration and address whether hearts regenerated from different progenitors respond equally well to further injuries. Our expected findings will constitute a paradigm shift on the origins of cardiovascular disease and define epigenetic priming as a basis for regeneration.

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The information about "TRANSREG" are provided by the European Opendata Portal: CORDIS opendata.

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