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TransReg SIGNED

Transgenerational epigenetic inheritance of cardiac regenerative capacity in the zebrafish

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TransReg project word cloud

Explore the words cloud of the TransReg project. It provides you a very rough idea of what is the project "TransReg" about.

unravel    mechanism    remodeling    zebrafish    animals    suffered    plasticity    basis    reconstruction    gene    rats    underlying    ventricular    infarction    toxicants    methylation    parental    revealed    shift    offspring    injuries    fish    leads    degree    time    sequence    cardiac    starting    while    tei    reveal    experiences    capacity    hepatic    humans    regeneration    transfer    describe    injury    causing    origins    functional    regenerative    constitute    regenerated    regenerate    starvation    modifications    rnas    cardiovascular    histone    suggested    analyze    cardiomyocyte    describes    equally    pivotal    regulatory    dna    metabolism    altered    myocardial    coding    parents    generation    hearts    models    cell    exposed    injured    elicits    sperm    priming    effect    transmitted    environment    grandchildren    grandparents    disease    first    play    transgenerational    genetic    elucidated    fibrosis    inheritance    paradigm    heart    influence    similarly    ultimately    progenitors    organ    gametes    independent    subpopulations    liver    network    epigenetic    model    adverse   

Project "TransReg" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙999˙125 €
 EC max contribution 1˙999˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 1˙672˙875.00
2    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) participant 326˙250.00

Map

 Project objective

While myocardial infarction leads to adverse ventricular remodeling ultimately causing heart failure in humans, some animals, including zebrafish can regenerate the injured heart. We recently revealed a high degree of plasticity in cardiomyocyte subpopulations involved in the reconstruction of the injured heart. The gene regulatory network involved in heart regeneration is starting to be elucidated and epigenetic remodeling has been suggested to play a pivotal role during this process. Similarly it is known that the environment can influence the regenerative capacity but whether such an effect can be transmitted from one generation to the next has not been addressed. This mechanism is called transgenerational epigenetic inheritance (TEI) and describes the transfer of experiences from parents to their offspring through the gametes, independent on changes in DNA sequence. TEI has also been described in humans: starvation suffered by grandparents affects the metabolism of grandchildren. TEI is also relevant to organ injury: in rats, offspring from parents exposed to liver toxicants revealed reduced hepatic fibrosis in response to the same injury. Changes in DNA methylation, histone modifications and non-coding RNAs have been associated to TEI. We aim to describe for the first time epigenetic inheritance of organ regeneration and unravel its underlying mechanism using the zebrafish model. We will assess whether cardiac injury elicits epigenetic modifications in sperm and determine if offspring from injured parental fish reveal altered heart regeneration. Genetic models will be developed for functional assessment of identified modifications. We will also further analyze cell plasticity during heart regeneration and address whether hearts regenerated from different progenitors respond equally well to further injuries. Our expected findings will constitute a paradigm shift on the origins of cardiovascular disease and define epigenetic priming as a basis for regeneration.

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The information about "TRANSREG" are provided by the European Opendata Portal: CORDIS opendata.

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