Opendata, web and dolomites


Molecular characterization of vesicle tethering complexes as novel regulators of collagen trafficking

Total Cost €


EC-Contrib. €






Project "COTETHERS" data sheet

The following table provides information about the project.


Organization address
address: STRADA NUOVA 65
city: PAVIA
postcode: 27100

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) coordinator 168˙277.00


 Project objective

Collagen maturation (through post-translational modifications, quaternary assembly and transport) is critical for tissues and organ development and homeostasis. This complex process involves numerous actors in different sub-cellular compartments, which in turn depend on highly regulated trafficking systems. Although the mechanisms of vesicular trafficking, membrane tethering and fusion are conserved throughout eukaryotic evolution, highly specialized tethering complexes have evolved to regulate specific fusion events. Recently, a novel pathway regulating collagen trafficking has been identified. Central to this pathway are two trafficking proteins, homologous to, but not part of, classical vesicle tethering components. At present, very little is known about their specific functions. Genetic mutations in both proteins induce rare but highly invalidating and often lethal phenotypes, characterized by abnormal collagen distribution, disorders of the extracellular matrix organization and impairment in endosomal trafficking. In this proposal, I will develop a multidisciplinary approach, merging cutting edge methodologies of affinity purification coupled to mass spectrometry with structural biology and biophysics to decipher the molecular mechanisms driving membrane tethering and, more broadly, endosomal trafficking, through this new complex. These results will unveil unprecedented mechanisms of vesicular trafficking, offering a potential for translational research on collagen-related diseases and also on disorders related to vesicular trafficking, possibly paving the way to future therapeutic strategies.


year authors and title journal last update
List of publications.
2018 Luigi Scietti, Antonella Chiapparino, Francesca De Giorgi, Marco Fumagalli, Lela Khoriauli, Solomon Nergadze, Shibom Basu, Vincent Olieric, Lucia Cucca, Blerida Banushi, Antonella Profumo, Elena Giulotto, Paul Gissen, Federico Forneris
Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05631-5
Nature Communications 9/1 2019-06-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COTETHERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COTETHERS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

Goc-MM (2019)

Human gut microbiota on gut-on-a-chip

Read More