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Impact of Intrapartum Antimicrobial Prophylaxis as an early determinant in Microbiome Development

Total Cost €


EC-Contrib. €






Project "IAPEMIDE" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

During the last decades, changes in diet and lifestyle have increased the risk of non-communicable diseases in the western countries. It is known that once they are established in the childhood, they continue into adult life with the associated negative impact on health, quality of life and health care costs. The correct establishment of the intestinal microbiota (IM) at the beginning of life plays a key role in health, reducing risk of chronic disease. Some factors affecting this process have been studied; however, other like the intrapartum antimicrobial prophylaxis (IAP), in spite of been present on over 30% of total deliveries, have been much less studied. It is already known that at least 11 types of broad-spectrum antibiotics cross the placenta and reach the foetus. Given the increasingly evident relationship between early microbiota, later disease risk and the rising worries regarding antimicrobial resistances, there is an urgent need to assess the potential adverse consequences of IAP in the establishment of the IM and resistome. This project will be the first to study mechanisms orchestrating the impact of IAP on the neonatal IM establishment. The objectives are: identify the alterations induced by IAP in the neonatal IM development; identify the antibiotic resistance genes that the IM carried as consequence of IAP; study the potential role of infant feeding in the modulation of the microbiota after IAP administration and design of specific dietary strategies for minimising the impact of IAP on the IM establishment. Moreover, if the breast-milk exerts a protective role, it would help to strengthen the maternal breast-feeding recommendations. Following this study, doctors will be better able to address the consequences to make knowledge-based decisions about IAP treatment in those situations where it is not extremely mandatory. Besides, the present project will represent a worthy opportunity for the applicant to improve her research competences and career.


year authors and title journal last update
List of publications.
2018 - G. Solís, M. Suárez, N. Fernández, L. Mantecón, S. Arboleya, A. Nogacka, C. Milani, C.G. de los Reyes-Gavilán, M. Ventura, M. Gueimonde
Metagenomics analysis disclose the impact of intrapartum antimicrobial prophylaxis in the early microbiome
published pages: , ISSN: , DOI:
J Pediatr Neonat Individual Med 2019-11-20
2018 Silvia Arboleya, M. Suárez, N. Fernández, L. Mantecón, G. Solís, M. Gueimonde, C.G. de los Reyes-Gavilán
C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health
published pages: 17-23, ISSN: 0250-6807, DOI: 10.1159/000490843
Annals of Nutrition and Metabolism 73/3 2019-11-20
2018 - G. Solís, S. Arboleya, M. Suárez, N. Fernández, L. Mantecón, A. Nogacka, C. Milani, C.G. de los Reyes-Gavilán, M. Ventura, M. Gueimonde
Intrapartum antimicrobial prophylaxis affects early-gut Bifidobacterium populations in healthy neonates
published pages: , ISSN: , DOI: 10.7363/070232
Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) 2019-11-20
2019 Saturio S., Nogacka A., Fernández N., Suárez M., Solís G., de los Reyes-Gavilán C.G., Gueimonde M., Arboleya S
Abstracts of the 10th Workshop on Probiotics and Prebiotics
published pages: 1-31, ISSN: 0250-6807, DOI: 10.1159/000496759
Annals of Nutrition and Metabolism 74/Suppl. 1 2019-11-20

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