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Manufacturing and Development for Rapid Access Ebola Vaccine (EBOMAN) – Sofia ref.: 115850

Total Cost €


EC-Contrib. €






Project "EBOMAN" data sheet

The following table provides information about the project.


Organization address
postcode: 27472
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 40˙188˙229 €
 EC max contribution 1˙023˙325 € (3%)
 Programme 1. H2020-EU. (Other)
 Code Call H2020-JTI-IMI2-2014-02-single-stage
 Funding Scheme IMI2-RIA
 Starting year 2014
 Duration (year-month-day) from 2014-12-01   to  2017-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIBALOGICS GMBH DE (CUXHAVEN) coordinator 1˙023˙325.00
2    BAVARIAN NORDIC AS DK (KVISTGARD) participant 0.00


 Project objective

This topic response (Topic 2: Manufacturing Capability) forms part of an integrated proposal to address the urgent unmet needs of accelerating the development of an Ebola vaccine. To help facilitate this main goal additional activities will be performed; the generation of sufficient vaccine and the capacity increase for generating more vaccine by means of process scale up and improvements.

The main objectives of this proposal are to manufacture sufficient supplies (and overages) for the clinical studies described in topic 1 and to prepare for a rapid access to large quantities of Ad26.ZEBOV (prime) and MVA-BN®-Filo (boost) vaccine in case of further escalation of the Ebola outbreak (The clinical development may change requiring an alternative vaccine combination; vaccination strategy. Any changes will be subsequently reflected in the manufacturing of clinical supplies). In conjunction with topic 3 (Transport and Rapid Access Ebola Vaccine) we should be able to respond quickly to future emergency needs of the vaccine.

The program therefore covers immediate manufacturing of clinical material and creation of additional capacity (by scale up, process improvements) and product understanding (BSL classification downgrading, process and product characterisation) to cope with increased need for the vaccine. The program includes:

Manufacturing, release and supply of Ad26.ZEBOV and MVA-BN®-Filo vaccine candidate for clinical studies (outcome: released clinical material)

Process Development activities required to ensure scale up of Ad26.ZEBOV manufacturing to 50L and fully define the 300L scale MVA BN®-Filo production.

Execute process development activities to ensure scale up of Ad26.ZEBOV and MVA-BN®-Filo to support potential manufacturing of up to 4M doses

Process Development and further scale up to support potential manufacturing of 10-20M doses

Generate material for further stability investigations towards late phase

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The information about "EBOMAN" are provided by the European Opendata Portal: CORDIS opendata.

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