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EpiScope SIGNED

Epigenomics and chromosome architecture one cell at a time

Total Cost €

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EC-Contrib. €

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Partnership

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 EpiScope project word cloud

Explore the words cloud of the EpiScope project. It provides you a very rough idea of what is the project "EpiScope" about.

specificity    genomic    functions    single    light    eukaryotes    100    transcription    territories    variations    marks    cell    chromosome    intermediate    structures    linked    cellular    maintenance    nucleus    genes    implicated    transcriptional    packing    documented    labeling    until    combinations    technologies    content    context    types    lack    correlate    nucleosomes    conformations    localization    relationships    unveil    multiple    epigenetic    functional    actors    function    establishment    dna    architecture    bp    thousands    responsible    microscopies    performance    tissue    patterns    hi    groundbreaking    correlated    preserving    scales    memory    efficient    molecular    3d    toolbox    map    distance    limited    tads    topologically    throughput    critically    megabase    microfluidics    identity    epigenomic    molecule    shed    interplay    length    associating    nuclear    pairwise    genome    domains    episcope    nanoscale    structure    landscape    differentiation    full    chromosomes    chromatin    loci    sub    mechanisms    organization   

Project "EpiScope" data sheet

The following table provides information about the project.

Coordinator		 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 1˙999˙780 €
 EC max contribution 1˙999˙780 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙999˙780.00

Map

 Project objective

In Eukaryotes, cellular identity and tissue-specific functions are linked to the epigenetic landscape and the multi-scale architecture of the genome. The packing of DNA into nucleosomes at the ~100 bp scale and the organization of whole chromosomes into functional territories within the nucleus are well documented. At an intermediate scale, chromosomes are organised in megabase to sub-megabase structures called Topologically Associating Domains (TADs). Critically, TADs are highly correlated to patterns of epigenetic marks determining the transcriptional state of the genes they encompass. Until now, the lack of efficient technologies to map chromosome architecture and epigenetic marks at the single-cell level have limited our understanding of the molecular actors and mechanisms implicated in the establishment and maintenance of the multi-scale architecture of chromosomes and epigenetic states, and the interplay between this architecture and other nuclear functions such as transcription. The overall aim of EpiScope is to unveil the functional, multi-scale, 3D architecture of chromatin at the single-cell level while preserving cellular context, with a toolbox of groundbreaking high-performance microscopies (Hi-M). Hi-M will use unique combinations of multi-focus and single-molecule localization microscopies with novel DNA labeling methods and microfluidics. Hi-M will enable the study of structure-function relationships within TADs of different chromatin types and correlate single-cell variations in epigenomic patterns to 3D conformations with genomic specificity and at the nanoscale. Finally, Hi-M will be used to develop a novel high-throughput, high-content method to unveil the full pairwise distance distribution between thousands of genomic loci at the single cell level and at multiple length-scales. Our findings and technologies will shed new light into the mechanisms responsible for cellular memory, identity and differentiation.

 Publications

year authors and title journal last update
List of publications.
2019 Andrés M. Cardozo Gizzi, Diego I. Cattoni, Jean-Bernard Fiche, Sergio M. Espinola, Julian Gurgo, Olivier Messina, Christophe Houbron, Yuki Ogiyama, Giorgio L. Papadopoulos, Giacomo Cavalli, Mounia Lagha, Marcelo Nollmann
Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms
published pages: 212-222.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.01.011 		Molecular Cell 74/1 2019-05-22
2018 Quentin Szabo, Daniel Jost, Jia-Ming Chang, Diego I. Cattoni, Giorgio L. Papadopoulos, Boyan Bonev, Tom Sexton, Julian Gurgo, Caroline Jacquier, Marcelo Nollmann, Frédéric Bantignies, Giacomo Cavalli
TADs are 3D structural units of higher-order chromosome organization in Drosophila
published pages: eaar8082, ISSN: 2375-2548, DOI: 10.1126/sciadv.aar8082 		Science Advances 4/2 2019-05-22

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The information about "EPISCOPE" are provided by the European Opendata Portal: CORDIS opendata.

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