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EASY

Epigenetic approach for the treatment of obesity

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Outcomes and results

 EASY project word cloud

Explore the words cloud of the EASY project. It provides you a very rough idea of what is the project "EASY" about.

therapeutic    link    histone    last    genome    fuel    scientific    amount    off    linked    reduce    stimuli    vitro    skills    7    diet    evidences    public    decades    therapeutics    epigenetic    spend    methyltransferases    data    budgets    intake    memory    point    markers    suv420h1    maintenance    economic    contributor    societal    dissect    shift    health    researcher    players    metabolic    suv420h    weight    strategies    preliminary    socio    epidemic    burning    countries    nutritional    obese    pivotal    obesity    capability    onset    attractive    occurs    excess    combine    desperately    transmission    dysregulation    expenditure    vivo    translate    overrated    brown    etiology    dissecting    group    mice    proteins    1980    generation    environmental    huge    treat    tissue    adipose    regulation    energy    toward    metabolism    knockout    unclear    gain    threefold    diseases    emerge    exercise    genes    it    exposure    balance    contributes    indicate    exceed    people    clinical    meaningfully    suv420h2   

Project "EASY" data sheet

The following table provides information about the project.

Coordinator		 OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Project website https://research.hsr.it/en/news/discovered-two-epigenetic-regulators-of-metabolism.html
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-12-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 168˙277.00

Map

 Project objective

It has been estimated a threefold increase in the number of obese people in Europe since the 1980’s. Currently, EU countries spend an average of 7% of their public health budgets on diseases linked to obesity. The socio-economic impact of obesity epidemic cannot be overrated. European societal needs require desperately a shift forward in the field of obesity research to be able to build new therapeutics strategies. Recent scientific evidences point toward a role of epigenetic changes as major contributor in the obesity etiology. In the last decades, a huge amount of data clearly link epigenetic dysregulation to obesity onset. Yet, it remains unclear whether epigenetic dysregulation contributes meaningfully to obesity epidemic. Because weight gain only occurs when energy intake exceed energy expenditure, burning off excess fuel represent an attractive path to reduce obesity when diet and exercise are not enough. My preliminary data indicate the histone methyltransferases Suv420h1 and Suv420h2 as pivotal players in metabolism regulation. By using knockout mice specifically in brown adipose tissue, this project aims at dissecting the role of Suv420h proteins in the etiology of obesity. I will combine in vivo and in vitro analyses and genome wide studies to: 1) dissect the role of Suv420h proteins in the epigenetic regulation of the pathways controlling weight balance in response to nutritional or environmental stimuli; 2) identify genes involved in the generation, maintenance or transmission of the epigenetic memory of exposure; 3) provide useful markers or therapeutic targets to treat obesity and metabolic diseases. My results have the potential to translate into therapeutics. This research will contribute to provide new clinical targets against obesity. The Experienced Researcher will emerge from the project with new skills, and the capability to lead her own research group.

 Publications

year authors and title journal last update
List of publications.
2019 Simona Pedrotti, Roberta Caccia, Maria Victoria Neguembor, Jose Manuel Garcia-Manteiga, Giulia Ferri, Clara de Palma, Tamara Canu, Matteo Giovarelli, Paolo Marra, Amleto Fiocchi, Ivan Molineris, Michele Raso, Francesca Sanvito, Claudio Doglioni, Antonio Esposito, Emilio Clementi, Davide Gabellini
The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli
published pages: eaav1472, ISSN: 2375-2548, DOI: 10.1126/sciadv.aav1472 		Science Advances 5/4 2020-03-23

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