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Evolution and development of pharyngeal pouches and pre-oral gut in basal fishes

Total Cost €


EC-Contrib. €






Project "Pharynx2016" data sheet

The following table provides information about the project.


Organization address
address: OVOCNY TRH 560/5
city: PRAHA 1
postcode: 116 36

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Project website
 Total cost 154˙720 €
 EC max contribution 154˙720 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERZITA KARLOVA CZ (PRAHA 1) coordinator 154˙720.00


 Project objective

Vertebrates, which include our own species, are the most diverse and successful group of Deuterostomes. Success of this group has been explained by the evolution of elaborated head skeleton adapted to capturing and processing large prey. Most of this skeleton derives from neural crest cells migrating into the pharynx during and after the formation of pharyngeal pouches. To better understand how development of these structures evolved, the research project will study representatives of three basal fish lineages that occupy key positions in jawed-vertebrate phylogeny. It will employ methods of genomics, gene expression, and gene manipulation including CRISPR/Cas9 gene editing system to test a mechanistic model of pouch formation and its relationships to pre-oral endoderm development. The proposal builds upon the Fellow’s research of jawed and jawless vertebrates and bridges a gap in our knowledge of the pharyngeal evolution between the jawed and jawless vertebrates and at the same time between vertebrates and their chordate and deuterostome ancestors. Two-way knowledge transfer is a crucial feature of this project: the Fellow will take advantage of the proficiency of the Supervisor and the Department in embryology, morphology, manipulation, and husbandry of the rare basal fishes and in the genomics and transcriptomics, while at the same time he will transfer his expertise in genetic regulation of development and CRISPR/Cas9 gene editing in non-model organisms to the Supervisor and Host Institution.


year authors and title journal last update
List of publications.
2019 Jan Stundl, Anna Pospisilova, David Jandzik, Peter Fabian, Barbora Dobiasova, Martin Minarik, Brian D Metscher, Vladimir Soukup, Robert Cerny
Bichir external gills arise via heterochronic shift that accelerates hyoid arch development
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.43531
eLife 8 2020-01-29
2019 Square TA, Jandzik D, Massey JL, Romasek M, Stein HP, Hansen AW, Purkayastha A Amrita, Cattell MV, Medeiros DM 2019
Cooption and Specialization of Endothelin Signaling Pathways Drove Elaboration of the Neural Crest in Early Vertebrates
published pages: , ISSN: 0000-0000, DOI: 10.1101/710475
BioRxiv 2020-01-29

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The information about "PHARYNX2016" are provided by the European Opendata Portal: CORDIS opendata.

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