Opendata, web and dolomites

HOST-SELECT SIGNED

Functional Analysis of Host Genetic Variants: Biomarker Selection Towards Improving Female Subfertility Diagnosis and Treatment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "HOST-SELECT" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 159˙460.00

Map

 Project objective

Roughly 15% of couples trying to conceive suffer from subfertility. One of its leading causes is developed pathology in woman’s fallopian tubes (tubal pathology or TP). Persistent infection with Chlamydia trachomatis (CT) is the single most common cause of TP. Women with a certain genetic makeup are more likely to develop TP after CT infection. I have so far identified 8 host genes and 13 genetic variants associated with CT infection and TP. Their exact function is, however, not yet elucidated. In this project, I will research the effect of found host genetic factors on CT infection and TP, by analysing their function in a human fallopian tube organoid model. This model optimally simulates in vivo conditions in the tubes. The host institution offers the technology and expertise for conducting such research. The analysis will be achieved via RNA interference gene-silencing technology, successfully applied by the host group in their CT research for years. I will then introduce targeted mutations via CRISPR/Cas9 gene-editing assay and study the effect on the course of the infection. Lastly, I will determine the network of involved gene pathways in order to explain the underlying pathogenesis. This will be the first ever functional analysis of host factors associated with CT infection and TP in an organoid. The analyses will require learning and applying cutting-edge techniques (RNA interference and CRISPR/Cas9). Also, it will be the first delivery of specific, targeted mutations into a CT-infected organoid and first such study of their effect on developing pathologies. Achieving these objectives will facilitate the development of a novel diagnostic assay in order to address an existing health need - improving the currently suboptimal diagnosis of women at risk of CT-associated TP and reducing referrals to invasive, burdening and costly surgical examinations. I have also developed a detailed plan for disseminating the findings to experts and general public.

 Publications

year authors and title journal last update
List of publications.
2018 Brankovic I*, Malogajski J*, Land JA, Morre SA, Ambrosino E.
POTENTIAL OF CHLAMYDIA TRACHOMATIS HOST GENETIC PROFILING TO MODIFY THE SCREENING FOR TUBAL FACTOR INFERTILITY (TFI) – THE DUTCH PERSPECTIVE
published pages: , ISSN: , DOI:
Proceedings of the Fourteenth International Symposium of Human Chlamydial Infections 6. July 2018. 2019-09-05
2019 Jelena Malogajski, Ivan Branković, Jolande A. Land, Pierre P. M. Thomas, Servaas A. Morré, Elena Ambrosino
The Potential Role for Host Genetic Profiling in Screening for Chlamydia-Associated Tubal Factor Infertility (TFI)—New Perspectives
published pages: 410, ISSN: 2073-4425, DOI: 10.3390/genes10060410
Genes 10/6 2019-09-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HOST-SELECT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HOST-SELECT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

qCHROMDEK (2019)

Quantitative insight into chromatin nanoscale structure: sub-nuclear organisation of oncoprotein DEK

Read More  

Language Use (2019)

Languages and Language Use

Read More  

GLYCO-WAY (2020)

Glycomics of Winery Antimicrobial Yeast

Read More