Explore the words cloud of the PlateletLiquidBiopsy project. It provides you a very rough idea of what is the project "PlateletLiquidBiopsy" about.
The following table provides information about the project.
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
|Coordinator Country||Germany [DE]|
|Total cost||159˙460 €|
|EC max contribution||159˙460 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-07-01 to 2019-06-30|
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|1||HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH||DE (NEUHERBERG)||coordinator||159˙460.00|
Cancer is one of the major causes of death worldwide. Early detection leads to treatment initiation in earlier cancer stages and therefore increases the chance of survival. However, appropriate diagnosis can be challenging because tissue acquisition of tumor samples for molecular testing often requires invasive procedure. To overcome these challenges researchers have focused on the real-time monitoring of molecules and cells in easily obtainable peripheral blood to gain diagnostic information, termed 'liquid biopsies'. A recent study by Best et al profiled purified platelet gene expression from cancer patients and healthy controls and was able to predict disease status and location of the primary tumor with 96% and 71% accuracy, respectively using a machine learning based algorithm. The pan-cancer nature of their finding is a major advancement compared to other liquid biopsy approaches and highlights the utility of platelets as an all-in-one platform for blood-based cancer diagnostics. We plan to advance the idea of platelet liquid biopsies by studying platelet single-cell RNA sequencing data from cancer patients and healthy controls. The overall goal of the proposed project is to investigate single platelet gene expression to gain insight into the molecular mechanisms underlying tumor driven changes in the platelet RNA profile.
|year||authors and title||journal||last update|
Herbert B Schiller, Daniel T Montoro, Lukas M Simon, Emma L Rawlins, Kerstin B Meyer, Maximilian Strunz, Felipe Vieira Braga, Wim Timens, Gerard H Koppelman, G.R. Scott Budinger, Janette K Burgess, Avinash Waghray, Maarten van den Berge, Fabian J Theis, Aviv Regev, Naftali Kaminski, Jayaraj Rajagopal, Sarah A Teichmann, Alexander V Misharin, Martijn C Nawijn
The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease
published pages: , ISSN: 1044-1549, DOI: 10.1165/rcmb.2018-0416tr
|American Journal of Respiratory Cell and Molecular Biology||2019-06-06|
Theis, Fabian; Deng, Li; Heinig, Matthias; Hense, Burkhard; Elbehery, Ali; Engel, Marion; Westermann, Alexander; Karg, Sebastian; Simon, Lukas
MetaMap: An atlas of metatranscriptomic reads in human disease-related RNA-seq data
published pages: , ISSN: 2047-217X, DOI: 10.1101/269092
Angelidis I, Simon LM, Fernandez IE, Strunz M, Mayr CH, Greiffo FR, Tsitsiridis G, Ansari M, Graf E, Strom TM, Nagendran M, Desai T, Eickelberg O, Mann M, Theis FJ, Schiller HB
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
published pages: , ISSN: 2041-1723, DOI:
Eraslan G, Simon LM, Mircea M, Mueller NS, Theis FJ
Single-cell RNA-seq denoising using a deep count autoencoder
published pages: , ISSN: 2041-1723, DOI:
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