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PlateletLiquidBiopsy TERMINATED

Exploring the cellular heterogeneity underlying 'tumor-educated' platelets

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PlateletLiquidBiopsy" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 159˙460.00

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 Project objective

Cancer is one of the major causes of death worldwide. Early detection leads to treatment initiation in earlier cancer stages and therefore increases the chance of survival. However, appropriate diagnosis can be challenging because tissue acquisition of tumor samples for molecular testing often requires invasive procedure. To overcome these challenges researchers have focused on the real-time monitoring of molecules and cells in easily obtainable peripheral blood to gain diagnostic information, termed 'liquid biopsies'. A recent study by Best et al profiled purified platelet gene expression from cancer patients and healthy controls and was able to predict disease status and location of the primary tumor with 96% and 71% accuracy, respectively using a machine learning based algorithm. The pan-cancer nature of their finding is a major advancement compared to other liquid biopsy approaches and highlights the utility of platelets as an all-in-one platform for blood-based cancer diagnostics. We plan to advance the idea of platelet liquid biopsies by studying platelet single-cell RNA sequencing data from cancer patients and healthy controls. The overall goal of the proposed project is to investigate single platelet gene expression to gain insight into the molecular mechanisms underlying tumor driven changes in the platelet RNA profile.

 Publications

year authors and title journal last update
List of publications.
2019 Herbert B Schiller, Daniel T Montoro, Lukas M Simon, Emma L Rawlins, Kerstin B Meyer, Maximilian Strunz, Felipe Vieira Braga, Wim Timens, Gerard H Koppelman, G.R. Scott Budinger, Janette K Burgess, Avinash Waghray, Maarten van den Berge, Fabian J Theis, Aviv Regev, Naftali Kaminski, Jayaraj Rajagopal, Sarah A Teichmann, Alexander V Misharin, Martijn C Nawijn
The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease
published pages: , ISSN: 1044-1549, DOI: 10.1165/rcmb.2018-0416tr
American Journal of Respiratory Cell and Molecular Biology 2019-06-06
2018 Theis, Fabian; Deng, Li; Heinig, Matthias; Hense, Burkhard; Elbehery, Ali; Engel, Marion; Westermann, Alexander; Karg, Sebastian; Simon, Lukas
MetaMap: An atlas of metatranscriptomic reads in human disease-related RNA-seq data
published pages: , ISSN: 2047-217X, DOI: 10.1101/269092
GigaScience 2019-06-06
2019 Angelidis I, Simon LM, Fernandez IE, Strunz M, Mayr CH, Greiffo FR, Tsitsiridis G, Ansari M, Graf E, Strom TM, Nagendran M, Desai T, Eickelberg O, Mann M, Theis FJ, Schiller HB
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
published pages: , ISSN: 2041-1723, DOI:
Nature Communications 2019-06-06
2019 Eraslan G, Simon LM, Mircea M, Mueller NS, Theis FJ
Single-cell RNA-seq denoising using a deep count autoencoder
published pages: , ISSN: 2041-1723, DOI:
Nature Communications 2019-06-06

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The information about "PLATELETLIQUIDBIOPSY" are provided by the European Opendata Portal: CORDIS opendata.

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