Opendata, web and dolomites

DYNAMO

Structural Dynamics of Membrane Receptors at native-like conditions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DYNAMO project word cloud

Explore the words cloud of the DYNAMO project. It provides you a very rough idea of what is the project "DYNAMO" about.

structural    topologies    flexible    nanodiscs    connecting    interdisciplinary    resolution    interaction    lipids    endogenous    secure    establishment    connected    pass    conformational    receptors    dynamo    energy    combining    combine    extended    assemblies    membrane    signaling    receptor    nanodisc    fellow    single    alternative    sans    host    drug    central    coagulation    scope    models    nature    function    methodology    techniques    tissue    domains    underlying    saxs    experimental    thereby    display    applicability    platform    selectivity    trafficking    designed    broaden    ghrelin    insights    chemistry    dynamics    ligands    combined    emphasis    integrative    protein    physics    vital    model    respectively    containing    ensemble    membranes    primary    expertise    blood    dynamical    native    implementing    fuzzy    functioning    biology    full    mrs    cell    dynamic    r1a    ghs    plays    length    genetic    tf    disorders    proteins    outside    computational    nmr    complexes    platforms    metabolic    functional    homeostasis    inside   

Project "DYNAMO" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

Proteins embedded in cell membranes are vital signaling and trafficking platforms connecting the outside to the inside of a cell, and functioning as primary drug targets. DYNAMO is an integrative dynamic structural biology project, with the ambitious goal of developing and implementing comprehensive experimental and computational approaches for studying the structural dynamics of membrane receptors (MRs) and their complexes at native-like conditions. DYNAMO is highly interdisciplinary, combining protein chemistry and computational physics to study dynamical processes underlying the function of MRs, and is designed to combine the expertise of the fellow and host. The project will establish an integrated platform based on the nanodisc-technology and the combined use of low- and high-resolution structural biology techniques to bring unique and alternative insights into the structural dynamics of MRs containing ”fuzzy” (i.e highly flexible) domains, and the role this plays in functional signaling assemblies. In order to broaden the scope of the project and secure a general applicability of the developed methodology, full-length tissue Factor (TF) and Ghrelin receptor (GHS-R1a) are selected as models of single-pass and multi-pass MRs. These MRs do not only display different topologies and functional assemblies but also different selectivity towards lipids. TF and GHS-R1a are central to blood coagulation and energy homeostasis, respectively, and also connected to genetic and metabolic disorders, and thereby not only relevant as model systems but also promising drug targets. The project will exploit the recent advances in SAXS/SANS- and NMR-based methods to study the TF and GHS-R1a in nanodiscs, with an emphasis on their conformational ensemble nature. Upon the establishment of the methodology, it will be extended to study the interaction with their endogenous ligands.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DYNAMO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DYNAMO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

RealFlex (2019)

Real-time simulator-driver design and manufacturing based on flexible systems

Read More  

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

IRF4 Degradation (2019)

Using a novel protein degradation approach to uncover IRF4-regulated genes in plasma cells

Read More  
lastchecktime (2025-05-21 2:36:42) correctly updated