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DYNAMO

Structural Dynamics of Membrane Receptors at native-like conditions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DYNAMO project word cloud

Explore the words cloud of the DYNAMO project. It provides you a very rough idea of what is the project "DYNAMO" about.

function    central    signaling    cell    biology    designed    energy    dynamics    scope    resolution    domains    thereby    receptors    r1a    dynamic    inside    emphasis    respectively    interaction    dynamical    ghrelin    nature    platform    combined    coagulation    membranes    endogenous    complexes    model    techniques    combine    alternative    insights    functioning    assemblies    nanodisc    expertise    metabolic    ligands    tissue    selectivity    structural    ghs    computational    implementing    fuzzy    vital    applicability    lipids    secure    mrs    chemistry    primary    single    broaden    models    integrative    platforms    sans    membrane    fellow    receptor    nmr    plays    physics    proteins    trafficking    connected    dynamo    outside    experimental    protein    methodology    full    connecting    topologies    drug    homeostasis    ensemble    display    genetic    host    nanodiscs    length    saxs    tf    combining    functional    blood    disorders    extended    conformational    interdisciplinary    flexible    establishment    pass    native    containing    underlying   

Project "DYNAMO" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

Proteins embedded in cell membranes are vital signaling and trafficking platforms connecting the outside to the inside of a cell, and functioning as primary drug targets. DYNAMO is an integrative dynamic structural biology project, with the ambitious goal of developing and implementing comprehensive experimental and computational approaches for studying the structural dynamics of membrane receptors (MRs) and their complexes at native-like conditions. DYNAMO is highly interdisciplinary, combining protein chemistry and computational physics to study dynamical processes underlying the function of MRs, and is designed to combine the expertise of the fellow and host. The project will establish an integrated platform based on the nanodisc-technology and the combined use of low- and high-resolution structural biology techniques to bring unique and alternative insights into the structural dynamics of MRs containing ”fuzzy” (i.e highly flexible) domains, and the role this plays in functional signaling assemblies. In order to broaden the scope of the project and secure a general applicability of the developed methodology, full-length tissue Factor (TF) and Ghrelin receptor (GHS-R1a) are selected as models of single-pass and multi-pass MRs. These MRs do not only display different topologies and functional assemblies but also different selectivity towards lipids. TF and GHS-R1a are central to blood coagulation and energy homeostasis, respectively, and also connected to genetic and metabolic disorders, and thereby not only relevant as model systems but also promising drug targets. The project will exploit the recent advances in SAXS/SANS- and NMR-based methods to study the TF and GHS-R1a in nanodiscs, with an emphasis on their conformational ensemble nature. Upon the establishment of the methodology, it will be extended to study the interaction with their endogenous ligands.

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The information about "DYNAMO" are provided by the European Opendata Portal: CORDIS opendata.

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