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DYNAMO

Structural Dynamics of Membrane Receptors at native-like conditions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DYNAMO project word cloud

Explore the words cloud of the DYNAMO project. It provides you a very rough idea of what is the project "DYNAMO" about.

r1a    scope    containing    domains    integrative    nature    dynamical    functioning    endogenous    energy    applicability    connecting    extended    host    interaction    combining    blood    selectivity    tissue    nanodiscs    dynamics    designed    emphasis    assemblies    fellow    structural    experimental    conformational    metabolic    length    tf    trafficking    combine    computational    ghs    plays    genetic    dynamo    protein    disorders    central    insights    methodology    receptor    sans    flexible    ghrelin    topologies    functional    ensemble    platforms    full    thereby    vital    platform    alternative    biology    inside    display    native    membrane    mrs    chemistry    combined    model    techniques    ligands    cell    single    broaden    primary    membranes    expertise    function    coagulation    resolution    receptors    connected    implementing    interdisciplinary    models    signaling    lipids    proteins    fuzzy    saxs    establishment    physics    secure    nmr    homeostasis    dynamic    respectively    pass    nanodisc    drug    outside    underlying    complexes   

Project "DYNAMO" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

Proteins embedded in cell membranes are vital signaling and trafficking platforms connecting the outside to the inside of a cell, and functioning as primary drug targets. DYNAMO is an integrative dynamic structural biology project, with the ambitious goal of developing and implementing comprehensive experimental and computational approaches for studying the structural dynamics of membrane receptors (MRs) and their complexes at native-like conditions. DYNAMO is highly interdisciplinary, combining protein chemistry and computational physics to study dynamical processes underlying the function of MRs, and is designed to combine the expertise of the fellow and host. The project will establish an integrated platform based on the nanodisc-technology and the combined use of low- and high-resolution structural biology techniques to bring unique and alternative insights into the structural dynamics of MRs containing ”fuzzy” (i.e highly flexible) domains, and the role this plays in functional signaling assemblies. In order to broaden the scope of the project and secure a general applicability of the developed methodology, full-length tissue Factor (TF) and Ghrelin receptor (GHS-R1a) are selected as models of single-pass and multi-pass MRs. These MRs do not only display different topologies and functional assemblies but also different selectivity towards lipids. TF and GHS-R1a are central to blood coagulation and energy homeostasis, respectively, and also connected to genetic and metabolic disorders, and thereby not only relevant as model systems but also promising drug targets. The project will exploit the recent advances in SAXS/SANS- and NMR-based methods to study the TF and GHS-R1a in nanodiscs, with an emphasis on their conformational ensemble nature. Upon the establishment of the methodology, it will be extended to study the interaction with their endogenous ligands.

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The information about "DYNAMO" are provided by the European Opendata Portal: CORDIS opendata.

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