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DYNAMO

Structural Dynamics of Membrane Receptors at native-like conditions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DYNAMO project word cloud

Explore the words cloud of the DYNAMO project. It provides you a very rough idea of what is the project "DYNAMO" about.

complexes    domains    model    insights    functional    genetic    endogenous    metabolic    outside    scope    connecting    structural    single    methodology    experimental    trafficking    containing    models    platform    underlying    native    fellow    computational    host    flexible    dynamics    broaden    nanodiscs    blood    assemblies    biology    selectivity    chemistry    homeostasis    receptor    functioning    platforms    combined    receptors    designed    alternative    nanodisc    ghs    length    ligands    display    connected    expertise    integrative    membranes    implementing    disorders    lipids    proteins    emphasis    vital    extended    thereby    signaling    secure    establishment    fuzzy    dynamical    respectively    drug    membrane    applicability    protein    ensemble    function    resolution    saxs    tf    interdisciplinary    pass    inside    tissue    dynamic    sans    coagulation    mrs    central    conformational    nature    cell    plays    combining    interaction    primary    combine    dynamo    r1a    techniques    full    nmr    ghrelin    topologies    physics    energy   

Project "DYNAMO" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

Proteins embedded in cell membranes are vital signaling and trafficking platforms connecting the outside to the inside of a cell, and functioning as primary drug targets. DYNAMO is an integrative dynamic structural biology project, with the ambitious goal of developing and implementing comprehensive experimental and computational approaches for studying the structural dynamics of membrane receptors (MRs) and their complexes at native-like conditions. DYNAMO is highly interdisciplinary, combining protein chemistry and computational physics to study dynamical processes underlying the function of MRs, and is designed to combine the expertise of the fellow and host. The project will establish an integrated platform based on the nanodisc-technology and the combined use of low- and high-resolution structural biology techniques to bring unique and alternative insights into the structural dynamics of MRs containing ”fuzzy” (i.e highly flexible) domains, and the role this plays in functional signaling assemblies. In order to broaden the scope of the project and secure a general applicability of the developed methodology, full-length tissue Factor (TF) and Ghrelin receptor (GHS-R1a) are selected as models of single-pass and multi-pass MRs. These MRs do not only display different topologies and functional assemblies but also different selectivity towards lipids. TF and GHS-R1a are central to blood coagulation and energy homeostasis, respectively, and also connected to genetic and metabolic disorders, and thereby not only relevant as model systems but also promising drug targets. The project will exploit the recent advances in SAXS/SANS- and NMR-based methods to study the TF and GHS-R1a in nanodiscs, with an emphasis on their conformational ensemble nature. Upon the establishment of the methodology, it will be extended to study the interaction with their endogenous ligands.

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The information about "DYNAMO" are provided by the European Opendata Portal: CORDIS opendata.

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