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FunKeyGut SIGNED

Illuminating Functional Networks and Keystone Species in the Gut

Total Cost €

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EC-Contrib. €

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Partnership

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 FunKeyGut project word cloud

Explore the words cloud of the FunKeyGut project. It provides you a very rough idea of what is the project "FunKeyGut" about.

interactions    symbiosis    revealed    cooperating    ultimately    intriguing    prebiotic    outstanding    secondary    microbiota    disease    elucidated    illuminate    enteropathogen    unravel    live    exists    human    vital    uniquely    diverse    probiotic    rumonicoccus    provides    catalogue    ion    network    networks    associating    native    intimate    complexity    sequencing    spectrometry    community    microbes    play    suited    treatments    mass    nanosims    though    dietary    keystone    species    webs    thought    designed    diet    gut    stable    microbial    shape    certain    protect    microbiome    raman    links    labeling    unknown    function    reveal    competing    exclusively    manipulating    situ    functional    services    communities    vitamin    metabolic    discoveries    microspectroscopy    isotope    ideal    organisms    rationally    health    ideally    environment    immune    training    breakdown    identity    largely    form    compounds    bromii    food    infection   

Project "FunKeyGut" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://dome.csb.univie.ac.at/research/illuminating-functional-networks-and-keystone-species-in-the-gut-funkeygut
 Total cost 1˙498˙279 €
 EC max contribution 1˙498˙279 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙498˙279.00

Map

 Project objective

We live in an intimate symbiosis with our gut microbiota, which provides us services such as vitamin production, breakdown of dietary compounds, and immune training. Sequencing-based approaches that have been applied to catalogue the gut microbiota have revealed intriguing discoveries associating the microbiome with diet and disease. The next outstanding challenge is to unravel the many activities and interactions that define gut microbiota function.

The gut microbiota is a diverse community of cooperating and competing microbes. These interactions form a network that links organisms with each other and their environment. Interactions in such a “functional network” are based partially, though not exclusively, on food webs. Certain “keystone species”, such as Rumonicoccus bromii, are thought to play a major role in these networks. Though some evidence exists for the presence of keystone species, their identity and activity remains largely unknown. As keystone species are vital to networks they are ideal targets for manipulating the gut microbiota to improve metabolic health and protect against enteropathogen infection.

Given the complexity of the gut microbiota, networks can only be elucidated directly in the native community. This project aims to identify functional networks and keystone species in the human gut using novel approaches that are uniquely and ideally suited for studying microbial activity in complex communities. Using state-of-the-art methods such as stable isotope labeling, Raman microspectroscopy, and secondary ion mass spectrometry (NanoSIMS) we will illuminate functional networks in situ. This will allow us to identify what factors shape gut microbiota activity, reveal important food webs, and ultimately use network knowledge to target the microbiota with prebiotic/probiotic treatments rationally designed to promote health.

 Publications

year authors and title journal last update
List of publications.
2019 Alessandra Riva, Orest Kuzyk, Erica Forsberg, Gary Siuzdak, Carina Pfann, Craig Herbold, Holger Daims, Alexander Loy, Benedikt Warth, David Berry
A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12413-0
Nature Communications 10/1 2019-12-16
2019 Simone Herp, Sandrine Brugiroux, Debora Garzetti, Diana Ring, Lara M. Jochum, Markus Beutler, Claudia Eberl, Saib Hussain, Steffi Walter, Roman G. Gerlach, Hans J. Ruscheweyh, Daniel Huson, Mikael E. Sellin, Emma Slack, Buck Hanson, Alexander Loy, John F. Baines, Philipp Rausch, Marijana Basic, André Bleich, David Berry, Bärbel Stecher
Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis
published pages: 681-694.e8, ISSN: 1931-3128, DOI: 10.1016/j.chom.2019.03.004
Cell Host & Microbe 25/5 2019-12-16
2019 Gomes, Oudot, Macià, Foito, Carregosa, Stewart, Van de Wiele, Berry, Motilva, Brenner, dos Santos
Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota
published pages: 2634, ISSN: 2072-6643, DOI: 10.3390/nu11112634
Nutrients 11/11 2019-12-16
2019 Kang Soo Lee, Márton Palatinszky, Fátima C. Pereira, Jen Nguyen, Vicente I. Fernandez, Anna J. Mueller, Filippo Menolascina, Holger Daims, David Berry, Michael Wagner, Roman Stocker
An automated Raman-based platform for the sorting of live cells by functional properties
published pages: 1035-1048, ISSN: 2058-5276, DOI: 10.1038/s41564-019-0394-9
Nature Microbiology 4/6 2019-12-16
2017 Jesse P. Harrison, David Berry
Vibrational Spectroscopy for Imaging Single Microbial Cells in Complex Biological Samples
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00675
Frontiers in Microbiology 8 2019-10-08

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