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FunKeyGut SIGNED

Illuminating Functional Networks and Keystone Species in the Gut

Total Cost €

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EC-Contrib. €

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Partnership

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 FunKeyGut project word cloud

Explore the words cloud of the FunKeyGut project. It provides you a very rough idea of what is the project "FunKeyGut" about.

catalogue    suited    training    uniquely    labeling    links    mass    services    microbes    vital    spectrometry    ion    ultimately    native    infection    outstanding    discoveries    diverse    exists    ideal    exclusively    protect    keystone    communities    species    intriguing    ideally    certain    largely    though    enteropathogen    microbial    rationally    interactions    vitamin    live    play    unknown    manipulating    disease    human    identity    isotope    gut    dietary    designed    microbiome    complexity    illuminate    situ    raman    diet    secondary    nanosims    cooperating    reveal    bromii    unravel    organisms    food    stable    microbiota    elucidated    prebiotic    function    metabolic    health    provides    form    microspectroscopy    symbiosis    network    community    revealed    competing    environment    compounds    rumonicoccus    thought    functional    networks    intimate    immune    associating    shape    webs    treatments    probiotic    sequencing    breakdown   

Project "FunKeyGut" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://dome.csb.univie.ac.at/research/illuminating-functional-networks-and-keystone-species-in-the-gut-funkeygut
 Total cost 1˙498˙279 €
 EC max contribution 1˙498˙279 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙498˙279.00

Map

 Project objective

We live in an intimate symbiosis with our gut microbiota, which provides us services such as vitamin production, breakdown of dietary compounds, and immune training. Sequencing-based approaches that have been applied to catalogue the gut microbiota have revealed intriguing discoveries associating the microbiome with diet and disease. The next outstanding challenge is to unravel the many activities and interactions that define gut microbiota function.

The gut microbiota is a diverse community of cooperating and competing microbes. These interactions form a network that links organisms with each other and their environment. Interactions in such a “functional network” are based partially, though not exclusively, on food webs. Certain “keystone species”, such as Rumonicoccus bromii, are thought to play a major role in these networks. Though some evidence exists for the presence of keystone species, their identity and activity remains largely unknown. As keystone species are vital to networks they are ideal targets for manipulating the gut microbiota to improve metabolic health and protect against enteropathogen infection.

Given the complexity of the gut microbiota, networks can only be elucidated directly in the native community. This project aims to identify functional networks and keystone species in the human gut using novel approaches that are uniquely and ideally suited for studying microbial activity in complex communities. Using state-of-the-art methods such as stable isotope labeling, Raman microspectroscopy, and secondary ion mass spectrometry (NanoSIMS) we will illuminate functional networks in situ. This will allow us to identify what factors shape gut microbiota activity, reveal important food webs, and ultimately use network knowledge to target the microbiota with prebiotic/probiotic treatments rationally designed to promote health.

 Publications

year authors and title journal last update
List of publications.
2019 Alessandra Riva, Orest Kuzyk, Erica Forsberg, Gary Siuzdak, Carina Pfann, Craig Herbold, Holger Daims, Alexander Loy, Benedikt Warth, David Berry
A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12413-0
Nature Communications 10/1 2019-12-16
2019 Simone Herp, Sandrine Brugiroux, Debora Garzetti, Diana Ring, Lara M. Jochum, Markus Beutler, Claudia Eberl, Saib Hussain, Steffi Walter, Roman G. Gerlach, Hans J. Ruscheweyh, Daniel Huson, Mikael E. Sellin, Emma Slack, Buck Hanson, Alexander Loy, John F. Baines, Philipp Rausch, Marijana Basic, André Bleich, David Berry, Bärbel Stecher
Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis
published pages: 681-694.e8, ISSN: 1931-3128, DOI: 10.1016/j.chom.2019.03.004
Cell Host & Microbe 25/5 2019-12-16
2019 Gomes, Oudot, Macià, Foito, Carregosa, Stewart, Van de Wiele, Berry, Motilva, Brenner, dos Santos
Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota
published pages: 2634, ISSN: 2072-6643, DOI: 10.3390/nu11112634
Nutrients 11/11 2019-12-16
2019 Kang Soo Lee, Márton Palatinszky, Fátima C. Pereira, Jen Nguyen, Vicente I. Fernandez, Anna J. Mueller, Filippo Menolascina, Holger Daims, David Berry, Michael Wagner, Roman Stocker
An automated Raman-based platform for the sorting of live cells by functional properties
published pages: 1035-1048, ISSN: 2058-5276, DOI: 10.1038/s41564-019-0394-9
Nature Microbiology 4/6 2019-12-16
2017 Jesse P. Harrison, David Berry
Vibrational Spectroscopy for Imaging Single Microbial Cells in Complex Biological Samples
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00675
Frontiers in Microbiology 8 2019-10-08

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