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TEMUBLYM SIGNED

Teleost mucosal B1-like lymphocytes at the crossroad of tolerance and immunity

Total Cost €

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EC-Contrib. €

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Partnership

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 TEMUBLYM project word cloud

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Project "TEMUBLYM" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA OA MP 

Organization address
address: Carretera de la Coruna Km7.5
city: MADRID
postcode: 28040
website: www.inia.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙866˙046 €
 EC max contribution 1˙866˙046 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA OA MP ES (MADRID) coordinator 1˙866˙046.00

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 Project objective

B cells are one of the main players of immunity, responsible for the production of immunoglobulins (Igs). In 2011, I was granted an ERC Starting grant to undertake the phenotypical and functional characterization of teleost B lymphocytes based on the hypothesis that they do not behave as mammalian B2 cells (conventional B cells) but closely resemble mammalian innate B1 lymphocytes involved in extrafollicular T-independent (TI) responses. Since then, my laboratory has gathered considerable evidences that strengthen this hypothesis. These studies were mostly carried out in central lymphoid compartments, but did not address how teleost B1-like cells regulate the delicate balance between immunity and tolerance at mucosal interfaces, in species lacking follicular structures. In this new project, I want to pursue my studies on B lymphocyte functionality, focusing on how teleost mucosal B cells are regulated, still under the assumption that fish B lymphocytes resemble better a B1 model. We will study how fish B cells differentiate to antibody secreting cells (ASCs) and establish extrafollicular long-term memory, taking into account novel results in mammals that have challenged traditional paradigms and revealed that long-term immunological memory can be established through TI IgM B1-like responses. Furthermore, we will also study the role of IgD in the gills, as previous studies from my group suggest that this Ig plays a key role in the regulation of immunity in this specific mucosa, as it seems to do in humans in areas such as the upper respiratory tract. Addressing how fish B cells mount a protective mucosal immune response in the absence of T cell help from organized follicles could provide new mechanistic insights into IgM and IgD responses emerging in humans. From a practical view, our work will contribute to understand why satisfactory mucosal vaccination is still an unreached goal for most diseases in both mammals and fish, despite their strong demand.

 Publications

year authors and title journal last update
List of publications.
2019 Pedro Perdiguero, Alba Martín-Martín, Ottavia Benedicenti, Patricia Díaz-Rosales, Esther Morel, Estefanía Muñoz-Atienza, Mónica García-Flores, Rocío Simón, Irene Soleto, Andrea Cerutti, Carolina Tafalla
Teleost IgD+IgM− B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles
published pages: 4223-4235.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.11.101
Cell Reports 29/13 2020-02-06
2019 Aitor G. Granja, Pedro Perdiguero, Alba Martín-Martín, Patricia Díaz-Rosales, Irene Soleto, Carolina Tafalla
Rainbow Trout IgM+ B Cells Preferentially Respond to Thymus-Independent Antigens but Are Activated by CD40L
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02902
Frontiers in Immunology 10 2020-02-06
2019 Rocío Simón, Patricia Díaz-Rosales, Esther Morel, Diana Martín, Aitor G. Granja, Carolina Tafalla
CpG Oligodeoxynucleotides Modulate Innate and Adaptive Functions of IgM+ B Cells in Rainbow Trout
published pages: 584, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00584
Frontiers in Immunology 10 2019-11-08
2019 Irene Soleto, Aitor G. Granja, Rocío Simón, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Identification of CD8α+ dendritic cells in rainbow trout (Oncorhynchus mykiss) intestine
published pages: 309-318, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.001
Fish & Shellfish Immunology 89 2019-11-08
2018 Irene Soleto, Esther Morel, Diana Martín, Aitor G. Granja, Carolina Tafalla
Regulation of IgM+ B Cell Activities by Rainbow Trout APRIL Reveals Specific Effects of This Cytokine in Lower Vertebrates
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01880
Frontiers in Immunology 9 2019-04-18
2018 Carolina Tafalla, Aitor G. Granja
Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01285
Frontiers in Immunology 9 2019-04-18
2018 Beatriz Abos, Itziar Estensoro, Pedro Perdiguero, Marc Faber, Yehfang Hu, Patricia Díaz Rosales, Aitor G. Granja, Christopher J. Secombes, Jason W. Holland, Carolina Tafalla
Dysregulation of B Cell Activity During Proliferative Kidney Disease in Rainbow Trout
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01203
Frontiers in Immunology 9 2019-04-18
2019 Patricia Díaz-Rosales, Estefanía Muñoz-Atienza, Carolina Tafalla
Role of teleost B cells in viral immunity
published pages: 135-142, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2018.11.039
Fish & Shellfish Immunology 86 2019-04-18
2018 Beatriz Abós, Steve Bird, Aitor G. Granja, Esther Morel, Juan A. More Bayona, Daniel R. Barreda, Carolina Tafalla
Identification of the First Teleost CD5 Molecule: Additional Evidence on Phenotypical and Functional Similarities between Fish IgM + B Cells and Mammalian B1 Cells
published pages: 465-480, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1701546
The Journal of Immunology 201/2 2019-04-18
2019 Estefanía Muñoz-Atienza, Carlos Távara, Patricia Díaz-Rosales, Luis Llanco, Enrique Serrano-Martínez, Carolina Tafalla
Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum
published pages: 25-34, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2018.11.027
Fish & Shellfish Immunology 86 2019-04-18

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