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LUMABS

Therapeutic antibody drug monitoring using bioluminescent sensors proteins and a smartphone

Total Cost €

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EC-Contrib. €

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Partnership

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Project "LUMABS" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 149˙750 €
 EC max contribution 149˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 149˙750.00

Map

 Project objective

Therapeutic antibodies represent an important class of newly introduced drugs and have been particularly successful in cancer therapy and the treatment of inflammatory diseases. The clearance rates of therapeutic antibodies are known to differ per individual and correlate with survival rates. Being able to define a personalized dose per patient based on continuous monitoring of therapeutic antibody levels would therefore be beneficial both for the individual patient and for the hospital’s budget. Our group recently developed a new platform of bioluminescent sensor proteins for antibody detection that allow antibody detection directly in blood plasma using the camera of a smart phone as the sole piece of equipment.

The goal of this ERC Proof-of-Concept is to establish LUMABS as a unique, low cost, and easily accessible point-of-care technology for monitoring therapeutic antibodies.

To enable clinical and commercial translation a product portfolio will be established that includes the development and validation of a prototype point-of-care assay for the therapeutic antibody Cetuximab. To establish LUMABS as a broadly applicable platform technology, we will use recently developed epitope screening technology to develop specific LUMABS sensors targeting Infliximab and biosimilar antibodies that are used to treat inflammatory conditions such as Crohns’ disease and rheumatoid arthritis. Based on an in-depth market analysis and the feedback we receive from external stakeholders on the performance of our technology, a realistic strategy will be developed for further translation and commercialization. During the project we will continuously assess opportunities for new patent applications. Our IP strategy will be guided by the outcome of our market examination and analysis of the most interesting business opportunities.

 Publications

year authors and title journal last update
List of publications.
2018 Keisuke Tenda, Benice van Gerven, Remco Arts, Yuki Hiruta, Maarten Merkx, Daniel Citterio
Paper-Based Antibody Detection Devices Using Bioluminescent BRET-Switching Sensor Proteins
published pages: 15369-15373, ISSN: 1433-7851, DOI: 10.1002/anie.201808070
Angewandte Chemie International Edition 57/47 2019-05-16
2018 Martijn van Rosmalen, Yan Ni, Daan F. M. Vervoort, Remco Arts, Susann K. J. Ludwig, Maarten Merkx
Dual-Color Bioluminescent Sensor Proteins for Therapeutic Drug Monitoring of Antitumor Antibodies
published pages: 3592-3599, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b00041
Analytical Chemistry 90/5 2019-05-16
2018 Yan Ni, Remco Arts, Maarten Merkx
Ratiometric Bioluminescent Sensor Proteins Based on Intramolecular Split Luciferase Complementation
published pages: 20-25, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b01381
ACS Sensors 4/1 2019-05-16

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The information about "LUMABS" are provided by the European Opendata Portal: CORDIS opendata.

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