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Clearance Of Microbial Biofilms by Advancing diagnostics and Therapy

Total Cost €


EC-Contrib. €






 COMBAT project word cloud

Explore the words cloud of the COMBAT project. It provides you a very rough idea of what is the project "COMBAT" about.

gene    genomics    effectiveness    clinical    plethora    bacterial    improvements    machine    domain    context    disease    medical    uses    group    genotype    eradicate    unprecedentedly    isolates    aeruginosa    morbidity    microbiological    teach    combat    molecular    every    alternative    tools    stress    treatment    variation    acute    expression    unsuccessful    national    mortality    strategies    pathogenic    pioneer    committed    calls    resistance    learning    meet    emergence    profiling    prediction    pseudomonas    diagnostics    last    transform    genome    science    modern    interference    combination    healthcare    microbial    therapeutic    unchanged    smaller    wealth    promise    data    antimicrobials    remained    services    holds    biology    sequence    patterns    attempts    invisible    bacteria    basic    association    strive    innovative    infection    patients    biofilm    dataset    paradigms    decades    burden    solutions    chronic    interpreted    billion    unlock    infections    suffering    perspectives    despite   

Project "COMBAT" data sheet

The following table provides information about the project.


Organization address
postcode: 38124

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙998˙750 €
 EC max contribution 1˙998˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Every year chronic infections in patients due to biofilm formation of pathogenic bacteria are a multi-billion Euro burden to national healthcare systems. Despite improvements in technology and medical services, morbidity and mortality due to chronic infections have remained unchanged over the past decades. The emergence of a chronic infection disease burden calls for the development of modern diagnostics for biofilm resistance profiling and new therapeutic strategies to eradicate biofilm-associated infections. However, many unsuccessful attempts to address this need teach us that alternative perspectives are needed to meet the challenges. The project is committed to develop innovative diagnostics and to strive for therapeutic solutions in patients suffering from biofilm-associated infections. The objective is to apply data-driven science to unlock the potential of microbial genomics. This new approach uses tools of advanced microbiological genomics and machine learning in genome-wide association studies on an existing unprecedentedly large dataset. This dataset has been generated in my group within the last five years and comprises sequence variation and gene expression information of a plethora of clinical Pseudomonas aeruginosa isolates. The wealth of patterns and characteristics of biofilm resistance are invisible at a smaller scale and will be interpreted within context and domain-specific knowledge. The unique combination of basic molecular biology research, technology-driven approaches and data-driven science allows pioneer research dedicated to advance strategies to combat biofilm-associated infections. My approach does not only provide a prediction of biofilm resistance based on the bacteria´s genotype but also holds promise to transform treatment paradigms for the management of chronic infections and by interference with bacterial stress responses will promote the effectiveness of antimicrobials in clinical use to eradicate biofilm infections.

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The information about "COMBAT" are provided by the European Opendata Portal: CORDIS opendata.

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