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ENCOPOL SIGNED

Encoding information into polymers

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ENCOPOL" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙498˙076 €
 EC max contribution 2˙498˙076 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙498˙076.00

Map

 Project objective

The amount of information trafficking internet nowadays is enormous and will increase further in the near future. It can be expected that in the next decennia the current technologies to store and process data will no longer suffice and that other strategies to handle information have to be developed. One approach is to explore chemical routes, which nature has also followed during evolution: our brain can store and handle very large amounts of data and process them in a way silicon-based computers cannot do. Although brain-like chemical computers are still far beyond reach, it is of interest to explore how atom and molecule-based systems that can write, read, and store information might be designed and constructed. In this proposal we aim at developing a new technology to write, store, and read information, i.e. on a single polymer chain with the help of a molecular machine that is inspired by the hypothetical device (Turing machine) proposed by the British mathematician Alan Turing in 1936 as the general basis for the operation of a computer. The molecular machine is composed of a chiral catalytic cage compound (tape-head) that moves unidirectionally along a chiral polymer chain (tape) while writing a binary code in the form of (R)- (symbol 0) and (S)- (symbol 1) epoxide functions. This writing process is controlled by light or electrons. The information on the tape will be read by single molecule spectroscopy using a reading device that is also based on a chiral cage compound. It moves along the encoded tape and produces left- or right-handed polarized fluorescence light depending on whether it reads a 0 (R-epoxide) or 1 (S-epoxide). As part of this project we will also make the first steps towards chemical computing by arranging two circular tapes (one left-handed and the other one right-handed), each with an attached writing head, in a teller set-up, which allows them to be addressed separately with light according to a set of instructions (Minsky machine).

 Publications

year authors and title journal last update
List of publications.
2018 Shaji Varghese, Paul B. White, Johannes A. A. W. Elemans, Bram Spierenburg, Roeland J. M. Nolte
Directional threading of a chiral porphyrin cage compound onto viologen guests
published pages: 12491-12494, ISSN: 1359-7345, DOI: 10.1039/c8cc05804k
Chemical Communications 54/88 2020-02-19
2018 Marga C. Lensen, Roeland J. M. Nolte, Alan E. Rowan, Wim Pyckhout-Hintzen, Martin C. Feiters, Johannes A. A. W. Elemans
Self-assembly of porphyrin hexamers via bidentate metal–ligand coordination
published pages: 14277-14287, ISSN: 1477-9226, DOI: 10.1039/c8dt01572d
Dalton Transactions 47/40 2020-02-19
2019 Shaji Varghese, Bram Spierenburg, Jeroen P. J. Bruekers, Anne Swartjes, Paul B. White, Johannes A. A. W. Elemans, Roeland J. M. Nolte
Effect of Chirality on the Binding of Viologen Guests in Porphyrin Macrocycles
published pages: 3525-3533, ISSN: 1434-193X, DOI: 10.1002/ejoc.201900221
European Journal of Organic Chemistry 2019/21 2020-02-19
2018 Martin G. T. A. Rutten, Frits W. Vaandrager, Johannes A. A. W. Elemans, Roeland J. M. Nolte
Encoding information into polymers
published pages: 365-381, ISSN: 2397-3358, DOI: 10.1038/s41570-018-0051-5
Nature Reviews Chemistry 2/11 2020-02-19
2018 M. Damen, A. J. J. Groenen, S. F. M. van Dongen, R. J. M. Nolte, B. J. Scholte, M. C. Feiters
Transfection by cationic gemini lipids and surfactants
published pages: 1404-1425, ISSN: 2040-2503, DOI: 10.1039/c8md00249e
MedChemComm 9/9 2020-02-19
2019 Yingfeng Tu, Fei Peng, Josje M. Heuvelmans, Shuwen Liu, Roeland J. M. Nolte, Daniela A. Wilson
Motion Control of Polymeric Nanomotors Based on Host-Guest Interactions
published pages: 8687-8691, ISSN: 1433-7851, DOI: 10.1002/anie.201900917
Angewandte Chemie International Edition 58/26 2020-02-19
2018 Suzanne B. P. E. Timmermans, Daan F. M. Vervoort, Lise Schoonen, Roeland J. M. Nolte, Jan C. M. van Hest
Self-Assembly and Stabilization of Hybrid Cowpea Chlorotic Mottle Virus Particles under Nearly Physiological Conditions
published pages: 3518-3525, ISSN: 1861-4728, DOI: 10.1002/asia.201800842
Chemistry - An Asian Journal 13/22 2020-02-19
2019 Ivan Bernar, Floris Rutjes, Johannes Elemans, Roeland Nolte
Aerobic Epoxidation of Low-Molecular-Weight and Polymeric Olefins by a Supramolecular Manganese Porphyrin Catalyst
published pages: 195, ISSN: 2073-4344, DOI: 10.3390/catal9020195
Catalysts 9/2 2020-02-19
2019 Johannes A. A. W. Elemans, Roeland J. M. Nolte
Porphyrin cage compounds based on glycoluril – from enzyme mimics to functional molecular machines
published pages: 9590-9605, ISSN: 1359-7345, DOI: 10.1039/c9cc04372a
Chemical Communications 55/65 2020-02-19
2018 Daniël C. Schoenmakers, Lise Schoonen, Martin G. T. A. Rutten, Roeland J. M. Nolte, Alan E. Rowan, Jan C. M. van Hest, Paul H. J. Kouwer
Virus-like particles as crosslinkers in fibrous biomimetic hydrogels: approaches towards capsid rupture and gel repair
published pages: 1442-1448, ISSN: 1744-683X, DOI: 10.1039/c7sm02320k
Soft Matter 14/8 2020-02-19
2018 S. F. M. van Dongen, J. Clerx, O. I. van den Boomen, M. Pervaiz, M. A. Trakselis, T. Ritschel, L. Schoonen, D. C. Schoenmakers, R. J. M. Nolte
Synthetic polymers as substrates for a DNA-sliding clamp protein
published pages: e23119, ISSN: 0006-3525, DOI: 10.1002/bip.23119
Biopolymers 109/5 2020-02-19
2019 Pieter J. Gilissen, Anne Swartjes, Bram Spierenburg, Jeroen P.J. Bruekers, Paul Tinnemans, Paul B. White, Floris P.J.T. Rutjes, Roeland J.M. Nolte, Johannes A.A.W. Elemans
Rapid and scalable synthesis of chiral porphyrin cage compounds
published pages: 4640-4647, ISSN: 0040-4020, DOI: 10.1016/j.tet.2019.07.009
Tetrahedron 75/33 2020-02-19
2018 Qi-Wei Zhang, Johannes A. A. W. Elemans, Paul B. White, Roeland J. M. Nolte
A manganese porphyrin–α-cyclodextrin conjugate as an artificial enzyme for the catalytic epoxidation of polybutadiene
published pages: 5586-5589, ISSN: 1359-7345, DOI: 10.1039/c8cc02320d
Chemical Communications 54/44 2020-02-19
2018 Shaji Varghese, Bram Spierenburg, Anne Swartjes, Paul B. White, Paul Tinnemans, Johannes A. A. W. Elemans, Roeland J. M. Nolte
Direct Synthesis of Chiral Porphyrin Macrocyclic Receptors via Regioselective Nitration
published pages: 3719-3722, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b01055
Organic Letters 20/13 2020-02-19
2018 Lise Schoonen, Selma Eising, Mark B. van Eldijk, Jaleesa Bresseleers, Margo van der Pijl, Roeland J. M. Nolte, Kimberly M. Bonger, Jan C. M. van Hest
Modular, Bioorthogonal Strategy for the Controlled Loading of Cargo into a Protein Nanocage
published pages: 1186-1193, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00815
Bioconjugate Chemistry 29/4 2020-02-19

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