Explore the words cloud of the CODECHECK project. It provides you a very rough idea of what is the project "CODECHECK" about.
The following table provides information about the project.
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
|Coordinator Country||Portugal [PT]|
|Total cost||2˙323˙468 €|
|EC max contribution||2˙323˙468 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-07-01 to 2021-06-30|
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|1||INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC||PT (PORTO)||coordinator||2˙323˙468.00|
During the human lifetime 10000 trillion cell divisions take place to ensure tissue homeostasis and several vital functions in the organism. Mitosis is the process that ensures that dividing cells preserve the chromosome number of their progenitors, while deviation from this, a condition known as aneuploidy, represents the most common feature in human cancers. Here we will test two original concepts with strong implications for chromosome segregation fidelity. The first concept is based on the “tubulin code” hypothesis, which predicts that molecular motors “read” tubulin post-translational modifications on spindle microtubules. Our proof-of-concept experiments demonstrate that tubulin detyrosination works as a navigation system that guides chromosomes towards the cell equator. Thus, in addition to regulating the motors required for chromosome motion, the cell might regulate the tracks in which they move on. We will combine proteomic, super-resolution and live-cell microscopy, with in vitro reconstitutions, to perform a comprehensive survey of the tubulin code and the respective implications for motors involved in chromosome motion, mitotic spindle assembly and correction of kinetochore-microtubule attachments. The second concept is centered on the recently uncovered chromosome separation checkpoint mediated by a midzone-associated Aurora B gradient, which delays nuclear envelope reformation in response to incompletely separated chromosomes. We aim to identify Aurora B targets involved in the spatiotemporal regulation of the anaphase-telophase transition. We will establish powerful live-cell microscopy assays and a novel mammalian model system to dissect how this checkpoint allows the detection and correction of lagging/long chromosomes and DNA bridges that would otherwise contribute to genomic instability. Overall, this work will establish a paradigm shift in our understanding of how spatial information is conveyed to faithfully segregate chromosomes during mitosis.
|year||authors and title||journal||last update|
Hugo GirÃ£o, Naoyuki Okada, Tony A. Rodrigues, Alexandra O. Silva, Ana C. Figueiredo, Zaira Garcia, Tatiana Moutinho-Santos, Ikuko Hayashi, Jorge E. Azevedo, Sandra Macedo-Ribeiro, Helder Maiato
CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments
published pages: jcb.201905080, ISSN: 0021-9525, DOI: 10.1083/jcb.201905080
|The Journal of Cell Biology||2020-04-08|
Olga Afonso, Colleen M Castellani, Liam P Cheeseman, Jorge G Ferreira, Bernardo Orr, Luisa T Ferreira, James J Chambers, Eurico Morais-de-SÃ¡, Thomas J Maresca, Helder Maiato
Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.47646
Danica Drpic, Ana C. Almeida, Paulo Aguiar, Fioranna Renda, Joana Damas, Harris A. Lewin, Denis M. Larkin, Alexey Khodjakov, Helder Maiato
Chromosome Segregation Is Biased by Kinetochore Size
published pages: , ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.03.023
Helder Maiato, Ana Gomes, Filipe Sousa, Marin Barisic
Mechanisms of Chromosome Congression during Mitosis
published pages: 13, ISSN: 2079-7737, DOI: 10.3390/biology6010013
Swadhin Chandra Jana, Susana MendonÃ§a, Pedro Machado, Sascha Werner, Jaqueline Rocha, AntÃ³nio Pereira, Helder Maiato, MÃ³nica Bettencourt-Dias
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity
published pages: 928-941, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0132-1
|Nature Cell Biology 20/8||2020-04-08|
Bernardo Orr, Helder Maiato
No chromosome left behind: The importance of metaphase alignment for mitotic fidelity
published pages: jcb.201902041, ISSN: 0021-9525, DOI: 10.1083/jcb.201902041
|The Journal of Cell Biology||2020-04-08|
Ana C Figueiredo, Helder Maiato
Kinetochore regulation: Let there be light
published pages: 1058-1059, ISSN: 1552-4450, DOI: 10.1038/nchembio.2464
|Nature Chemical Biology 13/10||2020-04-08|
AntÃ³nio Pereira, Mafalda Sousa, Ana C. Almeida, LuÃsa T. Ferreira, Ana Rita Costa, Marco Novais-Cruz, Cristina FerrÃ¡s, MÃ³nica Mendes Sousa, Paula Sampaio, Michael Belsley, Helder Maiato
Coherent-hybrid STED: high contrast sub-diffraction imaging using a bi-vortex depletion beam
published pages: 8092, ISSN: 1094-4087, DOI: 10.1364/oe.27.008092
|Optics Express 27/6||2020-04-08|
Anna Akhmanova, Helder Maiato
Closing the tubulin detyrosination cycle
published pages: 1381-1382, ISSN: 0036-8075, DOI: 10.1126/science.aar3895
Kuan-Chung Su, Zachary Barry, Nina Schweizer, Helder Maiato, Mark Bathe, IainÂ McPherson Cheeseman
A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition
published pages: 1728-1738, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.10.046
|Cell Reports 17/7||2020-04-08|
Marco Novais-Cruz, Maria Alba Abad, Wilfred FJ van IJcken, Niels Galjart, A Arockia Jeyaprakash, Helder Maiato, Cristina FerrÃ¡s
Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.36898
Ana C. Almeida, Helder Maiato
published pages: R1131-R1135, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.07.017
|Current Biology 28/19||2020-04-08|
Helder Maiato, Cristina FerrÃ¡s
Actin divides to conquer
published pages: 756-757, ISSN: 0036-8075, DOI: 10.1126/science.aao2461
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