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ADVANTAGE SIGNED

ADvanced Validation of A Novel TB Active disease diagnostic to address Global unmet needs: a European consortium approach

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 ADVANTAGE project word cloud

Explore the words cloud of the ADVANTAGE project. It provides you a very rough idea of what is the project "ADVANTAGE" about.

point    packages    standards    active    advantage    stimulate    platform    diagnostics    unmet    microfluidic    plus    mediated    massive    security    commercialisation    accounting    poorly    panel    analytes    regulatory    companies    structured    samples    improvements    globally    ing    supply    transitioning    diagnostic    ground    proteinlogic    summary    deaths    company    global    care    patient    demonstrated    successfully    poc    rapid    private    investment    performance    assay    despite    eight    healthcare    validated    protein    efforts    biomarkers    practises    cell    bn    analytical    validation    commercial    jobs    serum    reduce    slow    tuberculosis    hold    instrument    breaking    reader    disruptive    proven    confirm    successful    uk    400    elusive    biomarker    creation    yield    human    reagents    meet    burden    tb    selective    proof    1    risks    time    costly    laboratory    eradicate    profile    clinical    million    variety    biosensia    clear    cartridge   

Project "ADVANTAGE" data sheet

The following table provides information about the project.

Coordinator		 PROTEINLOGIC LIMITED 

Organization address
address: SHAKESPEARE HOUSE 42 NEWMARKET ROAD
city: CAMBRIDGE CAMBRIDGESHIRE
postcode: CB5 8EP
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website http://www.proteinlogic.com
 Total cost 3˙893˙307 €
 EC max contribution 3˙583˙396 € (92%)
 Programme 1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-2-2014
 Funding Scheme SME-2
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PROTEINLOGIC LIMITED UK (CAMBRIDGE CAMBRIDGESHIRE) coordinator 2˙921˙750.00
2    BIOSENSIA LIMITED IE (DUBLIN) participant 661˙646.00

Map

 Project objective

Tuberculosis (TB) remains an EU and global healthcare priority resulting in over 1.4 million deaths each year. Despite this and efforts to reduce TB by the EU commission, the WHO and others, a simple, rapid, diagnostic test for active tuberculosis (TB) remains elusive. Current diagnostic procedures, while accounting for over $1 bn globally, are poorly selective for active TB, hold risks for healthcare personnel, are slow to yield results and costly.

The large potential and high unmet need provide a clear target for commercialisation of a point-of-care (POC) test. Using over 400 clinical samples, ProteinLogic (a UK based diagnostics company) have demonstrated proof of concept for a ground-breaking approach using a panel of protein biomarkers on human serum samples that profile the cell mediated patient response to TB.

The objectives of the eight structured work packages within this three year project are to build on the validation of the biomarker TB panel transitioning from a laboratory assay to Biosensia’s novel microfluidic POC platform that has already been successfully proven with a variety of human analytes. Reagents will be developed as part of this project to ensure reduced costs and security of commercial supply. A unique instrument reader plus TB cartridge-based product will be developed to meet EU regulatory standards. The products will be validated in order to confirm analytical and clinical performance, and to provide evidence of major time, cost & performance improvements compared to current TB testing practises. Successful commercialisation will lead to the creation of over 30 new jobs and will stimulate further private investment in each of the companies.

In summary, ADVANTAGE has the potential to deliver a disruptive POC TB diagnostic test that can help eradicate the massive TB burden not only in EU but also globally.

 Deliverables

List of deliverables.
Clone scale Websites, patent fillings, videos etc. 2019-05-30 13:18:55

Take a look to the deliverables list in detail:  detailed list of ADVANTAGE deliverables.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ADVANTAGE" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "ADVANTAGE" are provided by the European Opendata Portal: CORDIS opendata.

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