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FastBio SIGNED

A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans

Total Cost €

0

EC-Contrib. €

0

Partnership

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 FastBio project word cloud

Explore the words cloud of the FastBio project. It provides you a very rough idea of what is the project "FastBio" about.

elusive    regarding    timepoint    humans    biological    unconventional    compare    omics    human    data    molecular    manner    specified    vs    microbiome    associate    genomics    gut    strategy    nutrients    integrate    yield    eocc    model    interrogate    initiated    individuals    signatures    population    perturbation    statistics    expertise    abstain    dietary    cell    uncover    180    biomarker    culture    carry    follow    levels    biology    computational    first    assays    steady    nature    scientific    eggs    brings    explore    regime    childhood    metabolomics    sampling    insights    epidemiology    epigenomics    ground    temporally    enormous    potent    phenotypes    christian    translational    meat    cellular    structured    primary    transcriptomics    unstructured    genetic    breaking    functional    annually    acute    traits    investigation    regimes    physiological    medicine    eastern    diet    variation    200    dairy    eat    consensus    health    intake    church    anthropometric    orthodox    opportunity    signalling    organisms    days    followed    explored   

Project "FastBio" data sheet

The following table provides information about the project.

Coordinator
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

Organization address
address: FLEMING STREET 34
city: VARI-ATHENS
postcode: 16672
website: www.fleming.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING EL (VARI-ATHENS) coordinator 1˙500˙000.00

Map

 Project objective

Dietary intake has an enormous impact on aspects of human health, yet scientific consensus about how what we eat affects our biology remains elusive. To address the complex biological impact of diet, I propose to apply an unconventional, ‘humans-as-model-organisms’ approach to compare the molecular and functional effects of a highly structured dietary regime, specified by the Eastern Orthodox Christian Church (EOCC), to the unstructured diet followed by the general population. Individuals who follow the EOCC regime abstain from meat, dairy products and eggs for 180-200 days annually, in a temporally-structured manner initiated in childhood. I aim to explore the biological signatures of structured vs. unstructured diet by addressing three objectives. First I will investigate the effects of the two regimes, and of genetic variation, on higher-level phenotypes including anthropometric, physiological and biomarker traits. Second, I will carry out a comprehensive set of omics assays (metabolomics, transcriptomics, epigenomics and investigation of the gut microbiome), will associate omics phenotypes with genetic variation, and will integrate data across biological levels to uncover complex molecular signatures. Third, I will interrogate the functional consequences of dietary regimes at the cellular level through primary cell culture. Acute and long-term effects of dietary intake will be explored for all objectives through a two timepoint sampling strategy. This proposal therefore comprises a unique opportunity to study a specific perturbation (EOCC structured diet) introduced to a steady-state system (unstructured diet followed by the general population) in a ground-breaking human systems biology type of study. This approach brings together expertise from genomics, computational biology, statistics, medicine and epidemiology. It will lead to novel insights regarding the potent signalling nature of nutrients and is likely to yield results of high translational value.

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The information about "FASTBIO" are provided by the European Opendata Portal: CORDIS opendata.

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