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FastBio SIGNED

A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans

Total Cost €

0

EC-Contrib. €

0

Partnership

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 FastBio project word cloud

Explore the words cloud of the FastBio project. It provides you a very rough idea of what is the project "FastBio" about.

biomarker    genomics    specified    individuals    insights    translational    explored    200    dietary    follow    traits    statistics    expertise    phenotypes    medicine    anthropometric    explore    steady    metabolomics    physiological    epidemiology    brings    childhood    omics    breaking    biological    biology    yield    model    meat    molecular    genetic    microbiome    dairy    perturbation    intake    integrate    investigation    human    consensus    structured    initiated    variation    signatures    carry    culture    potent    acute    eat    cellular    timepoint    followed    assays    regimes    opportunity    sampling    eggs    epigenomics    interrogate    scientific    days    unconventional    health    church    first    nature    diet    christian    elusive    nutrients    eocc    annually    humans    functional    eastern    primary    enormous    associate    transcriptomics    population    temporally    regime    gut    computational    compare    regarding    signalling    cell    organisms    vs    data    abstain    180    orthodox    levels    ground    uncover    strategy    unstructured    manner   

Project "FastBio" data sheet

The following table provides information about the project.

Coordinator
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

Organization address
address: FLEMING STREET 34
city: VARI-ATHENS
postcode: 16672
website: www.fleming.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING EL (VARI-ATHENS) coordinator 1˙500˙000.00

Map

 Project objective

Dietary intake has an enormous impact on aspects of human health, yet scientific consensus about how what we eat affects our biology remains elusive. To address the complex biological impact of diet, I propose to apply an unconventional, ‘humans-as-model-organisms’ approach to compare the molecular and functional effects of a highly structured dietary regime, specified by the Eastern Orthodox Christian Church (EOCC), to the unstructured diet followed by the general population. Individuals who follow the EOCC regime abstain from meat, dairy products and eggs for 180-200 days annually, in a temporally-structured manner initiated in childhood. I aim to explore the biological signatures of structured vs. unstructured diet by addressing three objectives. First I will investigate the effects of the two regimes, and of genetic variation, on higher-level phenotypes including anthropometric, physiological and biomarker traits. Second, I will carry out a comprehensive set of omics assays (metabolomics, transcriptomics, epigenomics and investigation of the gut microbiome), will associate omics phenotypes with genetic variation, and will integrate data across biological levels to uncover complex molecular signatures. Third, I will interrogate the functional consequences of dietary regimes at the cellular level through primary cell culture. Acute and long-term effects of dietary intake will be explored for all objectives through a two timepoint sampling strategy. This proposal therefore comprises a unique opportunity to study a specific perturbation (EOCC structured diet) introduced to a steady-state system (unstructured diet followed by the general population) in a ground-breaking human systems biology type of study. This approach brings together expertise from genomics, computational biology, statistics, medicine and epidemiology. It will lead to novel insights regarding the potent signalling nature of nutrients and is likely to yield results of high translational value.

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The information about "FASTBIO" are provided by the European Opendata Portal: CORDIS opendata.

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