Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. fastbio

FastBio SIGNED

A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FastBio project word cloud

Explore the words cloud of the FastBio project. It provides you a very rough idea of what is the project "FastBio" about.

phenotypes    levels    integrate    insights    transcriptomics    strategy    biological    regimes    regarding    eat    breaking    explored    acute    nature    associate    humans    dairy    eocc    nutrients    biomarker    regime    specified    explore    cell    computational    interrogate    diet    unconventional    uncover    first    potent    culture    model    orthodox    physiological    statistics    steady    sampling    omics    ground    human    scientific    investigation    unstructured    epidemiology    genomics    eggs    cellular    signalling    days    opportunity    perturbation    temporally    followed    brings    church    gut    intake    data    childhood    anthropometric    microbiome    epigenomics    structured    compare    eastern    annually    yield    enormous    primary    meat    translational    health    abstain    elusive    expertise    organisms    follow    metabolomics    functional    medicine    200    christian    manner    population    dietary    timepoint    180    consensus    initiated    variation    genetic    vs    assays    signatures    carry    individuals    molecular    biology    traits   

Project "FastBio" data sheet

The following table provides information about the project.

Coordinator		 BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

Organization address
address: FLEMING STREET 34
city: VARI-ATHENS
postcode: 16672
website: www.fleming.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Greece [EL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING EL (VARI-ATHENS) coordinator 1˙500˙000.00

Map

 Project objective

Dietary intake has an enormous impact on aspects of human health, yet scientific consensus about how what we eat affects our biology remains elusive. To address the complex biological impact of diet, I propose to apply an unconventional, ‘humans-as-model-organisms’ approach to compare the molecular and functional effects of a highly structured dietary regime, specified by the Eastern Orthodox Christian Church (EOCC), to the unstructured diet followed by the general population. Individuals who follow the EOCC regime abstain from meat, dairy products and eggs for 180-200 days annually, in a temporally-structured manner initiated in childhood. I aim to explore the biological signatures of structured vs. unstructured diet by addressing three objectives. First I will investigate the effects of the two regimes, and of genetic variation, on higher-level phenotypes including anthropometric, physiological and biomarker traits. Second, I will carry out a comprehensive set of omics assays (metabolomics, transcriptomics, epigenomics and investigation of the gut microbiome), will associate omics phenotypes with genetic variation, and will integrate data across biological levels to uncover complex molecular signatures. Third, I will interrogate the functional consequences of dietary regimes at the cellular level through primary cell culture. Acute and long-term effects of dietary intake will be explored for all objectives through a two timepoint sampling strategy. This proposal therefore comprises a unique opportunity to study a specific perturbation (EOCC structured diet) introduced to a steady-state system (unstructured diet followed by the general population) in a ground-breaking human systems biology type of study. This approach brings together expertise from genomics, computational biology, statistics, medicine and epidemiology. It will lead to novel insights regarding the potent signalling nature of nutrients and is likely to yield results of high translational value.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FASTBIO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FASTBIO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More