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FastBio SIGNED

A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans

Total Cost €

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EC-Contrib. €

0

Partnership

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 FastBio project word cloud

Explore the words cloud of the FastBio project. It provides you a very rough idea of what is the project "FastBio" about.

regime    breaking    biology    nature    gut    days    expertise    integrate    insights    compare    cell    health    nutrients    eastern    enormous    computational    investigation    metabolomics    timepoint    church    annually    epigenomics    uncover    functional    eocc    physiological    variation    phenotypes    vs    yield    unconventional    translational    followed    meat    potent    data    medicine    specified    associate    sampling    molecular    explore    manner    population    consensus    elusive    microbiome    dairy    epidemiology    eggs    follow    unstructured    180    first    levels    acute    childhood    abstain    omics    brings    genetic    scientific    christian    model    interrogate    humans    individuals    perturbation    primary    cellular    signalling    carry    initiated    eat    regimes    biological    steady    signatures    genomics    ground    diet    regarding    temporally    intake    statistics    anthropometric    orthodox    culture    200    biomarker    strategy    traits    opportunity    structured    organisms    dietary    transcriptomics    explored    human    assays   

Project "FastBio" data sheet

The following table provides information about the project.

Coordinator
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

Organization address
address: FLEMING STREET 34
city: VARI-ATHENS
postcode: 16672
website: www.fleming.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING EL (VARI-ATHENS) coordinator 1˙500˙000.00

Map

 Project objective

Dietary intake has an enormous impact on aspects of human health, yet scientific consensus about how what we eat affects our biology remains elusive. To address the complex biological impact of diet, I propose to apply an unconventional, ‘humans-as-model-organisms’ approach to compare the molecular and functional effects of a highly structured dietary regime, specified by the Eastern Orthodox Christian Church (EOCC), to the unstructured diet followed by the general population. Individuals who follow the EOCC regime abstain from meat, dairy products and eggs for 180-200 days annually, in a temporally-structured manner initiated in childhood. I aim to explore the biological signatures of structured vs. unstructured diet by addressing three objectives. First I will investigate the effects of the two regimes, and of genetic variation, on higher-level phenotypes including anthropometric, physiological and biomarker traits. Second, I will carry out a comprehensive set of omics assays (metabolomics, transcriptomics, epigenomics and investigation of the gut microbiome), will associate omics phenotypes with genetic variation, and will integrate data across biological levels to uncover complex molecular signatures. Third, I will interrogate the functional consequences of dietary regimes at the cellular level through primary cell culture. Acute and long-term effects of dietary intake will be explored for all objectives through a two timepoint sampling strategy. This proposal therefore comprises a unique opportunity to study a specific perturbation (EOCC structured diet) introduced to a steady-state system (unstructured diet followed by the general population) in a ground-breaking human systems biology type of study. This approach brings together expertise from genomics, computational biology, statistics, medicine and epidemiology. It will lead to novel insights regarding the potent signalling nature of nutrients and is likely to yield results of high translational value.

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The information about "FASTBIO" are provided by the European Opendata Portal: CORDIS opendata.

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