Opendata, web and dolomites

TransfoPneumo SIGNED

Structure and Function of the Bacterial Transformasome

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TransfoPneumo project word cloud

Explore the words cloud of the TransfoPneumo project. It provides you a very rough idea of what is the project "TransfoPneumo" about.

basis    vivo    architecture    first    neisseria    dna    natural    ray    tomography    aureus    proteins    regulated    complementary    entry    functional    function    bacteria    streptococcus    gram    drives    combine    recombination    molecular    machinery    designated    negative    vitro    apparatus    transformation    resistance    pneumoniae    understand    vaccines    transformasome    pathogen    physiology    reduce    griffith    pilus    gonorrhoeae    promotes    human    crystallography    structural    protein    antibiotics    escape    electron    microscopy    pathogens    1928    pore    purified    integration    biology    intricate    multiprotein    insights    infection    discovered    positive    adaptability    complexes    genome    subsequent    staphylococcus    bacterial    situ    expressed    believe    fundamental    acquire    strategies    attain    cryo    entities    extracellular    biochemical    genetic    plasticity    elusive    divided    pneumococcal    dissect    competence    largely    structure    physiological   

Project "TransfoPneumo" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙920 €
 EC max contribution 1˙999˙920 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙999˙920.00

Map

 Project objective

Natural genetic transformation, first discovered in Streptococcus pneumoniae by Griffith in 1928, is observed in many Gram-negative and Gram-positive bacteria. This process promotes genome plasticity and adaptability. In particular, it enables many human pathogens such as Streptococcus pneumoniae, Staphylococcus aureus or Neisseria gonorrhoeae to acquire resistance to antibiotics and/or to escape vaccines. For natural transformation to occur, bacteria must develop a highly regulated physiological state called competence, during which a multiprotein machinery, designated as the transformasome, is specifically expressed. The transformasome drives the uptake of extracellular DNA and its subsequent integration into the bacterial genome. This intricate system can be divided into three functional entities: the transformation pilus, the DNA entry pore and the recombination apparatus. The architecture and function of the transformasome remains largely elusive. We propose to dissect the structure and function of this system in the human pathogen Streptococcus pneumoniae. We will combine four complementary approaches to attain our goal: (1) Molecular biology and biochemical studies in vitro (2) Structural biology on purified proteins or protein complexes using X-ray crystallography and cryo-electron microscopy (3) Structure-function studies in vitro and in vivo (4) Structural biology in situ using cryo-tomography. Overall, we believe this ambitious project will provide major insights to understand the molecular basis of bacterial transformation, a fundamental process in bacterial physiology. In addition, this project may provide new strategies to reduce pneumococcal adaptation during infection.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRANSFOPNEUMO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TRANSFOPNEUMO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

inhibiTOR (2020)

Novel selective mTORC1 inhibitors

Read More  

AllergenDetect (2019)

Comprehensive allergen detection using synthetic DNA libraries

Read More  

DOUBLE-TROUBLE (2020)

Replaying the ‘genome duplication’ tape of life: the importance of polyploidy for adaptation in a changing environment

Read More