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TransfoPneumo SIGNED

Structure and Function of the Bacterial Transformasome

Total Cost €

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EC-Contrib. €

0

Partnership

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 TransfoPneumo project word cloud

Explore the words cloud of the TransfoPneumo project. It provides you a very rough idea of what is the project "TransfoPneumo" about.

negative    complementary    transformasome    vaccines    bacteria    staphylococcus    gram    genetic    purified    biology    gonorrhoeae    aureus    entry    protein    complexes    genome    drives    electron    believe    pneumococcal    tomography    human    competence    positive    resistance    dissect    crystallography    discovered    fundamental    griffith    function    pneumoniae    largely    pathogen    transformation    cryo    neisseria    physiological    microscopy    understand    machinery    pore    integration    insights    functional    architecture    pilus    basis    subsequent    escape    biochemical    streptococcus    recombination    acquire    situ    1928    elusive    expressed    structural    pathogens    intricate    vitro    adaptability    entities    first    natural    promotes    bacterial    reduce    infection    strategies    extracellular    vivo    attain    molecular    apparatus    plasticity    antibiotics    ray    physiology    designated    regulated    combine    structure    divided    proteins    multiprotein    dna   

Project "TransfoPneumo" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙920 €
 EC max contribution 1˙999˙920 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙999˙920.00

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 Project objective

Natural genetic transformation, first discovered in Streptococcus pneumoniae by Griffith in 1928, is observed in many Gram-negative and Gram-positive bacteria. This process promotes genome plasticity and adaptability. In particular, it enables many human pathogens such as Streptococcus pneumoniae, Staphylococcus aureus or Neisseria gonorrhoeae to acquire resistance to antibiotics and/or to escape vaccines. For natural transformation to occur, bacteria must develop a highly regulated physiological state called competence, during which a multiprotein machinery, designated as the transformasome, is specifically expressed. The transformasome drives the uptake of extracellular DNA and its subsequent integration into the bacterial genome. This intricate system can be divided into three functional entities: the transformation pilus, the DNA entry pore and the recombination apparatus. The architecture and function of the transformasome remains largely elusive. We propose to dissect the structure and function of this system in the human pathogen Streptococcus pneumoniae. We will combine four complementary approaches to attain our goal: (1) Molecular biology and biochemical studies in vitro (2) Structural biology on purified proteins or protein complexes using X-ray crystallography and cryo-electron microscopy (3) Structure-function studies in vitro and in vivo (4) Structural biology in situ using cryo-tomography. Overall, we believe this ambitious project will provide major insights to understand the molecular basis of bacterial transformation, a fundamental process in bacterial physiology. In addition, this project may provide new strategies to reduce pneumococcal adaptation during infection.

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The information about "TRANSFOPNEUMO" are provided by the European Opendata Portal: CORDIS opendata.

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