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TransfoPneumo SIGNED

Structure and Function of the Bacterial Transformasome

Total Cost €

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EC-Contrib. €

0

Partnership

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 TransfoPneumo project word cloud

Explore the words cloud of the TransfoPneumo project. It provides you a very rough idea of what is the project "TransfoPneumo" about.

pathogen    complexes    pneumococcal    fundamental    1928    strategies    genetic    divided    understand    acquire    largely    recombination    negative    transformation    pathogens    integration    structural    biology    biochemical    vivo    vitro    apparatus    combine    pore    believe    basis    drives    subsequent    electron    human    adaptability    microscopy    machinery    positive    bacterial    aureus    vaccines    physiology    streptococcus    discovered    griffith    functional    cryo    tomography    resistance    dna    insights    genome    dissect    proteins    elusive    escape    promotes    crystallography    infection    function    pneumoniae    physiological    first    antibiotics    entry    reduce    expressed    protein    attain    designated    pilus    bacteria    ray    purified    entities    molecular    transformasome    neisseria    complementary    staphylococcus    structure    regulated    architecture    intricate    gram    extracellular    gonorrhoeae    natural    competence    situ    multiprotein    plasticity   

Project "TransfoPneumo" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙920 €
 EC max contribution 1˙999˙920 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙999˙920.00

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 Project objective

Natural genetic transformation, first discovered in Streptococcus pneumoniae by Griffith in 1928, is observed in many Gram-negative and Gram-positive bacteria. This process promotes genome plasticity and adaptability. In particular, it enables many human pathogens such as Streptococcus pneumoniae, Staphylococcus aureus or Neisseria gonorrhoeae to acquire resistance to antibiotics and/or to escape vaccines. For natural transformation to occur, bacteria must develop a highly regulated physiological state called competence, during which a multiprotein machinery, designated as the transformasome, is specifically expressed. The transformasome drives the uptake of extracellular DNA and its subsequent integration into the bacterial genome. This intricate system can be divided into three functional entities: the transformation pilus, the DNA entry pore and the recombination apparatus. The architecture and function of the transformasome remains largely elusive. We propose to dissect the structure and function of this system in the human pathogen Streptococcus pneumoniae. We will combine four complementary approaches to attain our goal: (1) Molecular biology and biochemical studies in vitro (2) Structural biology on purified proteins or protein complexes using X-ray crystallography and cryo-electron microscopy (3) Structure-function studies in vitro and in vivo (4) Structural biology in situ using cryo-tomography. Overall, we believe this ambitious project will provide major insights to understand the molecular basis of bacterial transformation, a fundamental process in bacterial physiology. In addition, this project may provide new strategies to reduce pneumococcal adaptation during infection.

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The information about "TRANSFOPNEUMO" are provided by the European Opendata Portal: CORDIS opendata.

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