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CATCH-U-DNA SIGNED

Capturing non-Amplified Tumor Circulating DNA with Ultrasound Hydrodynamics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CATCH-U-DNA" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website https://catch-u-dna.com
 Total cost 3˙412˙478 €
 EC max contribution 3˙411˙478 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 682˙500.00
2    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) participant 575˙337.00
3    PANEPISTIMIO KRITIS EL (RETHIMNO) participant 546˙000.00
4    ADVANCED WAVE SENSORS S.L. ES (VALENCIA) participant 524˙000.00
5    INSTITUT CURIE FR (PARIS) participant 456˙891.00
6    JOBST TECHNOLOGIES GMBH DE (FREIBURG) participant 319˙250.00
7    UNIVERSIDAD AUTONOMA DE MADRID ES (MADRID) participant 307˙500.00

Map

 Project objective

The project suggests replacing the labor-intensive, occasionally biased and costly PCR method currently used for the detection of genetic markers with a simple, non-PCR based DNA quantification method. The suggested system will exploit the ability of acoustic waves to probe the hydrodynamic shape of surface-bound molecules, rather than mass. The scientific challenge to be addressed is to push the limit of detection to the zM range obviating the need to use a polymerase for DNA amplification. The technological challenge is to fabricate ultra sensitive acoustic devices and after capturing with high efficiency very low numbers of DNA present in a complex medium detecting them on the device surface. These ambitious goals will be achieved by developing novel probes and nanoparticles of tailor-made sizes and shapes for enhanced acoustic response; exploiting high frequency acoustic devices up to the GHz range; and, employing magnetic beads with microfluidics for specific target-capturing and enrichment. The proof-of-principle will be demonstrated during the detection of circulating-tumor DNA (ctDNA), currently an area perceived by cancer researchers as the “Holy Grail” of future cancer diagnosis, prognosis and treatment. We intend to validate our integrated acoustic platform towards the detection of common mutations occurring in colorectal and lung cancers, i.e., KRAS, EGFR and BRAF in serum. We anticipate that the “CATCH-U-DNA” concept will set the foundations for a simpler, more sensitive and affordable diagnostic method, from which patients in both the developed and developing countries will greatly benefit.

 Deliverables

List of deliverables.
Targeted NGS analysis on the tissue samples of the 200 patients Documents, reports 2020-03-24 09:14:05
Website construction Websites, patent fillings, videos etc. 2020-03-24 09:14:05

Take a look to the deliverables list in detail:  detailed list of CATCH-U-DNA deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Karla Perez-Toralla, Iago Pereiro, Sonia Garrigou, Fahima Di Federico, Charlotte Proudhon, François-Clément Bidard, Jean-Louis Viovy, Valérie Taly, Stéphanie Descroix
Microfluidic extraction and digital quantification of circulating cell-free DNA from serum
published pages: 533-539, ISSN: 0925-4005, DOI: 10.1016/j.snb.2019.01.159
Sensors and Actuators B: Chemical 286 2020-03-24
2019 George Papadakis, Alexandros K. Pantazis, Maria Ntogka, Konstantinos Parasyris, Gesthimani-Ioanna Theodosi, Georgia Kaprou, Electra Gizeli
3D-printed Point-of-Care Platform for Genetic Testing of Infectious Diseases Directly in Human Samples Using Acoustic Sensors and a Smartphone
published pages: 1329-1336, ISSN: 2379-3694, DOI: 10.1021/acssensors.9b00264
ACS Sensors 4/5 2020-03-24

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The information about "CATCH-U-DNA" are provided by the European Opendata Portal: CORDIS opendata.

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