Explore the words cloud of the CATCH-U-DNA project. It provides you a very rough idea of what is the project "CATCH-U-DNA" about.
The following table provides information about the project.
IDRYMA TECHNOLOGIAS KAI EREVNAS
|Coordinator Country||Greece [EL]|
|Total cost||3˙412˙478 €|
|EC max contribution||3˙411˙478 € (100%)|
1. H2020-EU.1.2.1. (FET Open)
|Duration (year-month-day)||from 2017-06-01 to 2020-11-30|
Take a look of project's partnership.
|1||IDRYMA TECHNOLOGIAS KAI EREVNAS||EL (IRAKLEIO)||coordinator||682˙500.00|
|2||BEN-GURION UNIVERSITY OF THE NEGEV||IL (BEER SHEVA)||participant||575˙337.00|
|3||PANEPISTIMIO KRITIS||EL (RETHIMNO)||participant||546˙000.00|
|4||ADVANCED WAVE SENSORS S.L.||ES (VALENCIA)||participant||524˙000.00|
|5||INSTITUT CURIE||FR (PARIS)||participant||456˙891.00|
|6||JOBST TECHNOLOGIES GMBH||DE (FREIBURG)||participant||319˙250.00|
|7||UNIVERSIDAD AUTONOMA DE MADRID||ES (MADRID)||participant||307˙500.00|
The project suggests replacing the labor-intensive, occasionally biased and costly PCR method currently used for the detection of genetic markers with a simple, non-PCR based DNA quantification method. The suggested system will exploit the ability of acoustic waves to probe the hydrodynamic shape of surface-bound molecules, rather than mass. The scientific challenge to be addressed is to push the limit of detection to the zM range obviating the need to use a polymerase for DNA amplification. The technological challenge is to fabricate ultra sensitive acoustic devices and after capturing with high efficiency very low numbers of DNA present in a complex medium detecting them on the device surface. These ambitious goals will be achieved by developing novel probes and nanoparticles of tailor-made sizes and shapes for enhanced acoustic response; exploiting high frequency acoustic devices up to the GHz range; and, employing magnetic beads with microfluidics for specific target-capturing and enrichment. The proof-of-principle will be demonstrated during the detection of circulating-tumor DNA (ctDNA), currently an area perceived by cancer researchers as the “Holy Grail” of future cancer diagnosis, prognosis and treatment. We intend to validate our integrated acoustic platform towards the detection of common mutations occurring in colorectal and lung cancers, i.e., KRAS, EGFR and BRAF in serum. We anticipate that the “CATCH-U-DNA” concept will set the foundations for a simpler, more sensitive and affordable diagnostic method, from which patients in both the developed and developing countries will greatly benefit.
|Targeted NGS analysis on the tissue samples of the 200 patients||Documents, reports||2020-03-24 09:14:05|
|Website construction||Websites, patent fillings, videos etc.||2020-03-24 09:14:05|
Take a look to the deliverables list in detail: detailed list of CATCH-U-DNA deliverables.
|year||authors and title||journal||last update|
Karla Perez-Toralla, Iago Pereiro, Sonia Garrigou, Fahima Di Federico, Charlotte Proudhon, FranÃ§ois-ClÃ©ment Bidard, Jean-Louis Viovy, ValÃ©rie Taly, StÃ©phanie Descroix
Microfluidic extraction and digital quantification of circulating cell-free DNA from serum
published pages: 533-539, ISSN: 0925-4005, DOI: 10.1016/j.snb.2019.01.159
|Sensors and Actuators B: Chemical 286||2020-03-24|
George Papadakis, Alexandros K. Pantazis, Maria Ntogka, Konstantinos Parasyris, Gesthimani-Ioanna Theodosi, Georgia Kaprou, Electra Gizeli
3D-printed Point-of-Care Platform for Genetic Testing of Infectious Diseases Directly in Human Samples Using Acoustic Sensors and a Smartphone
published pages: 1329-1336, ISSN: 2379-3694, DOI: 10.1021/acssensors.9b00264
|ACS Sensors 4/5||2020-03-24|
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