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EcoImmuneCosts SIGNED

Immunity in Ecology and Evolution: 'Hidden' costs of disease, immune function and their consequences for Darwinian fitness

Total Cost €

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EC-Contrib. €

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Partnership

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 EcoImmuneCosts project word cloud

Explore the words cloud of the EcoImmuneCosts project. It provides you a very rough idea of what is the project "EcoImmuneCosts" about.

biology    advancing    reed    disease    envision    reactions    immunology    optimize    harmless    protection    false    captive    antagonistic    length    unfeasible    mechanisms    warblers    darwinian    mediating    quality    fig    immune    carefully    diseases    precautions    pathogens    uses    1a    analyze    causes    32    accumulate    ageing    autoimmune    ups    telomere    degradation    sexually    stress    wild    broad    function    conduct    evolution    previously    senescence    incl    translated    exploits    causative    diversity    integrates    molecular    variation    small    data    central    parasite    theory    edge    autoimmunity    oxidative    minimize    entail    patterns    notion    evolutionary    delayed    immunopathology    seemingly    songbird    virulent    accelerated    designed    infections    frontiers    gene    manipulate    medicine    degenerative    1b    pushing    unknown    eco    resistance    cutting    mechanism    causing    look    significance    exceptional    experiments    epidemiology    experimentally    provides    hidden    ecology    techniques    primary    mild    infection    suggests    fitness    infectious   

Project "EcoImmuneCosts" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 2˙500˙000.00

Map

 Project objective

Eco-immunology targets one of the great challenges in biology and medicine - how the immune system has evolved to optimize protection and minimize immunopathology (incl. autoimmune) costs. A primary target of my proposal is to study low-virulent pathogens causing mild infections, which for long have been considered harmless. Recent research suggests that this notion is false and that seemingly harmless pathogens entail delayed (‘hidden’) fitness costs. However, the mechanisms mediating these costs are still unknown. I will experimentally test if accelerated telomere degradation is a causative mechanism through which small immune costs can accumulate and be translated into senescence and reduced Darwinian fitness. Another key target is immune costs, which may be ‘hidden’ because of sexually antagonistic effects, and I will study how this may affect immune gene variation, immune costs and Darwinian fitness. These aspects are central for advancing our understanding of the evolution of disease resistance and immune function, incl. immune over-reactions (autoimmunity).

My project exploits a comprehensive 32-year study of great reed warblers to analyze selection patterns in the wild (Fig. 1a), and uses established captive songbird set-ups to conduct carefully designed experiments. The exceptional quality of the long-term data set, together with cutting-edge techniques to measure and manipulate parasite infection, telomere length, oxidative stress and immune gene diversity, provides exciting opportunities to conduct research that previously was unfeasible, pushing the rapidly growing field of eco-immunology (Fig. 1b) to new frontiers. The work integrates theory and methods of evolutionary ecology, immunology and molecular biology, and has broad significance including for e.g. epidemiology and ageing research. I envision my research to change how we look upon causes, consequences (and precautions) of mild infectious, autoimmune and degenerative diseases.

 Publications

year authors and title journal last update
List of publications.
2020 Jacob Roved, Bengt Hansson, Martin Stervander, Dennis Hasselquist, Helena Westerdahl
Non-random association of MHC-I alleles in favor of high diversity haplotypes in wild songbirds revealed by computer-assisted MHC haplotype inference using the R package MHCtools
published pages: , ISSN: , DOI: 10.1101/2020.03.24.005207
2020-04-01
2019 Jacob Roved
MHC polymorphism in a songbird: Fitness, mate choice, and sexual conflict
published pages: , ISSN: , DOI:
2020-04-01
2020 Emily A. O\'Connor, Dennis Hasselquist, Jan-Ã…ke Nilsson, Helena Westerdahl, Charlie K. Cornwallis
Wetter climates select for higher immune gene diversity in resident, but not migratory, songbirds
published pages: 20192675, ISSN: 0962-8452, DOI: 10.1098/rspb.2019.2675
Proceedings of the Royal Society B: Biological Sciences 287/1919 2020-03-05
2018 Jacob Roved, Bengt Hansson, Maja Tarka, Dennis Hasselquist, Helena Westerdahl
Evidence for sexual conflict over major histocompatibility complex diversity in a wild songbird
published pages: 20180841, ISSN: 0962-8452, DOI: 10.1098/rspb.2018.0841
Proceedings of the Royal Society B: Biological Sciences 285/1884 2019-06-11

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