Explore the words cloud of the BrainEnergy project. It provides you a very rough idea of what is the project "BrainEnergy" about.
The following table provides information about the project.
UNIVERSITY COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙499˙954 €|
|EC max contribution||2˙499˙954 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-09-01 to 2022-08-31|
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|1||UNIVERSITY COLLEGE LONDON||UK (LONDON)||coordinator||2˙499˙954.00|
Pericytes, located at intervals along capillaries, have recently been revealed as major controllers of brain blood flow. Normally, they dilate capillaries in response to neuronal activity, increasing local blood flow and energy supply. But in pathology they have a more sinister role. After artery block causes a stroke, the brain suffers from the so-called “no-reflow” phenomenon - a failure to fully reperfuse capillaries, even after the upstream occluded artery has been reperfused successfully. The resulting long-lasting decrease of energy supply damages neurons. I have shown that a major cause of no-reflow lies in pericytes: during ischaemia they constrict and then die in rigor. This reduces capillary diameter and blood flow, and probably degrades blood-brain barrier function. However, despite their crucial role in regulating blood flow physiologically and in pathology, little is known about the mechanisms by which pericytes function.
By using blood vessel imaging, patch-clamping, two-photon imaging, optogenetics, immunohistochemistry, mathematical modelling, and live human tissue obtained from neurosurgery, this programme of research will: (i) define the signalling mechanisms controlling capillary constriction and dilation in health and disease; (ii) identify the relative contributions of neurons, astrocytes and microglia to regulating pericyte tone; (iii) develop approaches to preventing brain pericyte constriction and death during ischaemia; (iv) define how pericyte constriction of capillaries and pericyte death contribute to Alzheimer’s disease; (v) extend these results from rodent brain to human brain pericytes as a prelude to developing therapies.
The diseases to which pericytes contribute include stroke, spinal cord injury, diabetes and Alzheimer’s disease. These all have an enormous economic impact, as well as causing great suffering for patients and their carers. This work will provide novel therapeutic approaches for treating these diseases.
|year||authors and title||journal||last update|
Christian Madry, I. Lorena Arancibia-CÃ¡rcamo, Vasiliki Kyrargyri, Victor T. T. Chan, Nicola B. Hamilton, David Attwell
Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion
published pages: E1608-E1617, ISSN: 0027-8424, DOI: 10.1073/pnas.1715354115
|Proceedings of the National Academy of Sciences 115/7||2019-05-16|
Jinping Cheng, Nils Korte, Ross Nortley, Huma Sethi, Yamei Tang, David Attwell
Targeting pericytes for therapeutic approaches to neurological disorders
published pages: , ISSN: 0001-6322, DOI: 10.1007/s00401-018-1893-0
Ross Nortley, David Attwell
Control of brain energy supply by astrocytes
published pages: 80-85, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.09.012
|Current Opinion in Neurobiology 47||2019-05-16|
Anusha Mishra, James P Reynolds, Yang Chen, Alexander V Gourine, Dmitri A Rusakov, David Attwell
Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles
published pages: 1619-1627, ISSN: 1097-6256, DOI: 10.1038/nn.4428
|Nature Neuroscience 19/12||2019-05-16|
Pablo Izquierdo, David Attwell, Christian Madry
Ion Channels and Receptors as Determinants of Microglial Function
published pages: 278-292, ISSN: 0166-2236, DOI: 10.1016/j.tins.2018.12.007
|Trends in Neurosciences 42/4||2019-05-16|
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