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MACULA2

Commercialising a novel diagnostic panel for patient stratification in Age-related MACULAr Degeneration

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MACULA2" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 150˙000.00

Map

 Project objective

'In MACULA2 we aim to develop a genetic diagnostic test for complement activation that will allow proper stratification of patients with age-related macular degeneration (AMD). AMD is an inflammatory disease, the #1 cause of blindness in the world, with 196 million patients estimated for 2020. Such a test does not currently exist, strongly hampering drug development and patient treatment. Poor patient stratification contributes to high failure rates in trials for AMD. Local and systemic inflammation in AMD are caused by deregulated activation of the alternative pathway of the complement system. In AMD, some patients have higher complement activation levels compared to controls, which stimulates further inflammation. Several complement-lowering therapies for AMD are under development. Pharmaceutical companies are aware that patients with a genetic predisposition to higher complement activation levels will potentially benefit most from such treatments. Without sound patient stratification, therapies that are currently in clinical trials may not reach the statistical significance needed for approval. However, certain individuals might actually benefit from these therapies because of their specific genetic makeup. We aim to solve the challenge of patient stratification in AMD by developing a novel diagnostic test based on genetic testing combined with a patient questionnaire. An AMD diagnostic test will contribute towards a precision medicine approach towards treatment of patients.'

 Publications

year authors and title journal last update
List of publications.
2018 Laura Lorés-Motta, Eiko K. de Jong, Anneke I. den Hollander
Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration
published pages: 315-343, ISSN: 1177-1062, DOI: 10.1007/s40291-018-0332-1
Molecular Diagnosis & Therapy 22/3 2019-11-06
2018 Laura Lorés-Motta, Constantin C. Paun, Jordi Corominas, Marc Pauper, Maartje J. Geerlings, Lebriz Altay, Tina Schick, Mohamed R. Daha, Sascha Fauser, Carel B. Hoyng, Anneke I. den Hollander, Eiko K. de Jong
Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation
published pages: , ISSN: 0161-6420, DOI: 10.1016/j.ophtha.2017.12.023
Ophthalmology 2019-11-06

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The information about "MACULA2" are provided by the European Opendata Portal: CORDIS opendata.

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