Explore the words cloud of the MALEPREG project. It provides you a very rough idea of what is the project "MALEPREG" about.
The following table provides information about the project.
HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL
|Coordinator Country||Germany [DE]|
|Total cost||1˙499˙989 €|
|EC max contribution||1˙499˙989 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-03-01 to 2023-02-28|
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|1||HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL||DE (KIEL)||coordinator||1˙499˙989.00|
The question of how sex roles and parental investment have evolved belongs to the most controversial unresolved issues in evolutionary biology. The costliest form of reproduction regarding parental investment is viviparity. Its independent evolution in most vertebrate groups has required drastic morphological and genomic reorganisations in the sex bearing the young. Yet our knowledge is heavily biased towards mammals, where changes in the immune system and microbial composition are associated with pregnancy and placentation. Which factors have caused the selection and accompanied evolution of viviparity in other vertebrates remains severely understudied. As the evolution of viviparity is a textbook model of convergent evolution, I plan on using a comparative approach to identify selection and fitness benefits leading to the evolution of viviparity. I propose analysing mating system evolution, focusing on the unique evolution of male pregnancy in sex-role reversed syngnathids (pipefishes and seahorses) that show a gradient from external fertilisation to full viviparity and are, thus, ideal to study the evolution of viviparity. Only this genus allows the role of egg production and viviparity to be disentangled, as both traits co-occur in the female in most other species. As immunological tolerance is fundamentally associated with the evolution of pregnancy, I will investigate how male pregnancy has coevolved with adaptive immune system rearrangements and the broodpouch specific microbiota. Comparative genomics, transcriptomics and genetic engineering utilizing CRISPR/Cas9 will elucidate the genetic basis of trait loss and gain required for male pregnancy. In particular, I will assess whether new functions arose via gene duplication and neo-functionalization, via gene co-option or via de novo gene emergence. This proposal will pave the way for studying viviparity evolution beyond the mammalian model and will provide a fresh look at sex roles and parental investment.
|year||authors and title||journal||last update|
Anne Beemelmanns, Maude Poirier, Till Bayer, Sven Kuenzel, Olivia Roth
Microbial embryonal colonization during pipefish male pregnancy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37026-3
|Scientific Reports 9/1||2019-11-07|
Charlotte Jessica E. Metcalf, Olivia Roth, Andrea L. Graham
Why leveraging sex differences in immune tradeâ€offs may illuminate the evolution of senescence
published pages: , ISSN: 0269-8463, DOI: 10.1111/1365-2435.13458
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