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MALEPREG SIGNED

Male pregnancy – Unravelling the coevolution of parental investment and immune defence

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 MALEPREG project word cloud

Explore the words cloud of the MALEPREG project. It provides you a very rough idea of what is the project "MALEPREG" about.

arose    microbial    genus    immune    genetic    functions    bearing    placentation    pave    emergence    unresolved    groups    morphological    crispr    trait    analysing    rearrangements    severely    de    form    model    gain    genomics    pipefishes    costliest    fundamentally    controversial    mammalian    utilizing    transcriptomics    seahorses    basis    gene    disentangled    mammals    evolution    sex    reorganisations    engineering    belongs    adaptive    gradient    vertebrates    external    heavily    full    parental    co    plan    pregnancy    genomic    cas9    fitness    coevolved    composition    question    fresh    traits    species    egg    neo    novo    ideal    fertilisation    textbook    mating    duplication    elucidate    option    convergent    reversed    roles    broodpouch    syngnathids    drastic    female    biased    look    investment    understudied    regarding    viviparity    biology    independent    caused    reproduction    accompanied    male    functionalization    immunological    tolerance    vertebrate    benefits    evolutionary    microbiota    young   

Project "MALEPREG" data sheet

The following table provides information about the project.

Coordinator		 HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL 

Organization address
address: WISCHHOFSTRASSE 1-3
city: KIEL
postcode: 24148
website: www.geomar.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website https://www.geomar.de/en/staff/fb3/ev/oroth/
 Total cost 1˙499˙989 €
 EC max contribution 1˙499˙989 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL DE (KIEL) coordinator 1˙499˙989.00

Map

 Project objective

The question of how sex roles and parental investment have evolved belongs to the most controversial unresolved issues in evolutionary biology. The costliest form of reproduction regarding parental investment is viviparity. Its independent evolution in most vertebrate groups has required drastic morphological and genomic reorganisations in the sex bearing the young. Yet our knowledge is heavily biased towards mammals, where changes in the immune system and microbial composition are associated with pregnancy and placentation. Which factors have caused the selection and accompanied evolution of viviparity in other vertebrates remains severely understudied. As the evolution of viviparity is a textbook model of convergent evolution, I plan on using a comparative approach to identify selection and fitness benefits leading to the evolution of viviparity. I propose analysing mating system evolution, focusing on the unique evolution of male pregnancy in sex-role reversed syngnathids (pipefishes and seahorses) that show a gradient from external fertilisation to full viviparity and are, thus, ideal to study the evolution of viviparity. Only this genus allows the role of egg production and viviparity to be disentangled, as both traits co-occur in the female in most other species. As immunological tolerance is fundamentally associated with the evolution of pregnancy, I will investigate how male pregnancy has coevolved with adaptive immune system rearrangements and the broodpouch specific microbiota. Comparative genomics, transcriptomics and genetic engineering utilizing CRISPR/Cas9 will elucidate the genetic basis of trait loss and gain required for male pregnancy. In particular, I will assess whether new functions arose via gene duplication and neo-functionalization, via gene co-option or via de novo gene emergence. This proposal will pave the way for studying viviparity evolution beyond the mammalian model and will provide a fresh look at sex roles and parental investment.

 Publications

year authors and title journal last update
List of publications.
2019 Anne Beemelmanns, Maude Poirier, Till Bayer, Sven Kuenzel, Olivia Roth
Microbial embryonal colonization during pipefish male pregnancy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37026-3 		Scientific Reports 9/1 2019-11-07
2019 Charlotte Jessica E. Metcalf, Olivia Roth, Andrea L. Graham
Why leveraging sex differences in immune trade‐offs may illuminate the evolution of senescence
published pages: , ISSN: 0269-8463, DOI: 10.1111/1365-2435.13458 		Functional Ecology 2019-11-07

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