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NanoVirus SIGNED

Deciphering virus-host interactions using correlated confocal-atomic force microscopy

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoVirus" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙998˙125 €
 EC max contribution 1˙998˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 1˙998˙125.00

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 Project objective

Viruses are a major class of pathogens that infect a variety of organisms. Infection is a multistep process that involves the concerted action of both virus and host cell machineries. The first steps of virus infection include cell binding, cell entry and release of the viral genetic material. Entry pathways are largely defined by the preliminary interactions between viruses and their receptors at the cell surface. Those interactions determine the mechanisms of virus attachment, uptake, and, ultimately, penetration into the cytosol. Elucidating the complex interplay between viruses and their receptors at the cell surface is an essential step towards establishing a full picture of the infection process.

Currently, a crucial challenge in virology is to develop a quantitative method to decipher the entry pathways of a virus, thus allowing the probing of the kinetics and energetic parameters of the interactions established between the virus and the cell surface. While current methods successfully describe the entry pathways, they fail in identifying in a quantitative manner the key steps such as energy intensive and high-affinity steps. To overcome this limitation, the ambition of this ERC proposal is to combine the latest generations of atomic force microscopes (AFM) with confocal laser scanning microscopes (CLSM). This will allow us to investigate and quantitatively characterize the early steps of single virus entry directly on living cells. At the frontiers of nanotechnology, biophysics and biology, this project aims at pushing the limits of AFM to enable us to better understand the molecular mechanisms of virus entry.

This project will have strong scientific and medical impacts. In virology, it will significantly improve the understanding of the mechanisms of virus infection. In medicine, the new method will help us and other researchers to screen new compounds that are targeting viral infection.

 Publications

year authors and title journal last update
List of publications.
2018 Martin Delguste, Caroline Zeippen, Bénédicte Machiels, Jan Mast, Laurent Gillet, David Alsteens
Multivalent binding of herpesvirus to living cells is tightly regulated during infection
published pages: eaat1273, ISSN: 2375-2548, DOI: 10.1126/sciadv.aat1273
Science Advances 4/8 2019-05-27

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The information about "NANOVIRUS" are provided by the European Opendata Portal: CORDIS opendata.

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