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VESSEL CO-COPTION SIGNED

Vessel co-option and radioresistance in glioblastoma

Total Cost €

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EC-Contrib. €

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Partnership

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 VESSEL CO-COPTION project word cloud

Explore the words cloud of the VESSEL CO-COPTION project. It provides you a very rough idea of what is the project "VESSEL CO-COPTION" about.

unknown    gsc    gbm    human    vessel    cellular    vessels    insights    caused    vascular    dynamics    clinically    multipotent    microscopy    organotypic    impacts    deadliest    underlying    exact    bulk    resection    co    therapeutic    renewing    receive    models    mechanism    chemotherapy    screenings    perivascular    fraction    regrowth    initiating    radiosensitize    multiple    space    stem    glioma    radiation    interaction    gscs    cancer    mechanistically    migration    attributed    intravital    involvement    brain    spreading    niche    glioblastoma    removed    hypothesis    highlights    aggressive    treatment    understand    90    uncover    patients    survival    resistance    rate    invasive    molecular    multiphoton    tumor    connections    confers    mostly    orthotopic    option    benefit    differentiated    regime    therapy    cells    cultures    despite    progression    radiotherapy    directional    strategies    efficacy    radioresistance    types    recurrence    self   

Project "VESSEL CO-COPTION" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙823 €
 EC max contribution 1˙499˙823 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 1˙499˙823.00

Map

 Project objective

Glioblastoma (GBM) is one of the deadliest types of human cancer. Despite a very aggressive treatment regime – including resection of the tumor, radiation and chemotherapy – its estimated recurrence rate is more than 90%. Recurrence is mostly caused by the regrowth of highly invasive cells spreading from the tumor bulk, which are not removed by resection. To develop an effective therapeutic approach, we need to better understand the underlying molecular mechanism of radiation resistance and tumor spreading in GBM. Radioresistance in GBM is attributed to glioma stem cells (GSCs), a fraction of perivascular, self-renewing, multipotent and tumor-initiating cells. Growing evidence highlights the perivascular space as a niche for GSC survival, resistance to therapy, progression and dissemination. The unknown factor is the dynamics of GSCs, how they end up in the vascular niche and how this impacts on radioresistance. My overall hypothesis is that GSCs reach the perivascular niche through vessel co-option - the directional migration of tumor cells towards vessels - and that targeting vessel co-option has the potential to radiosensitize GBM. With this project, we aim to uncover the exact molecular and cellular connections among vessel co-option, GSCs, the vascular niche and radioresistance. Using multiple strategies, such as multiphoton intravital microscopy, orthotopic models of GBM, organotypic cultures, screenings and survival studies, we will investigate and mechanistically change the dynamics of GSC and differentiated GBM cells in order to understand the role of their interaction with brain vessels and whether this confers resistance to radiotherapy. These studies will provide clinically relevant insights into the involvement of GSCs, the vascular niche and vessel co-option in the resistance of GBM to therapy. Since all GBM patients receive radiotherapy, many would benefit from therapeutic strategies aimed at increasing its efficacy.

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The information about "VESSEL CO-COPTION" are provided by the European Opendata Portal: CORDIS opendata.

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