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BIOCARD SIGNED

Deep BIOmodeling of human CARDiogenesis

Total Cost €

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EC-Contrib. €

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Partnership

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 BIOCARD project word cloud

Explore the words cloud of the BIOCARD project. It provides you a very rough idea of what is the project "BIOCARD" about.

matched    proliferation    extracellular    structures    embryogenesis    extensively    drug    time    technologies    mechanisms    matrix    models    organs    direct    culture    combining    native    centuries    molecular    biocard    lineage    cell    interspecies    decoding    anatomy    intermediates    hipsc    regenerative    therapies    human    first    ventricular    heart    multidisciplinary    hold    centred    bio    genomics    vitro    combinations    physiology    cardiac    muscle    genetic    vivo    inter    analysing    cells    modification    biomedical    functional    principles    game    health    pools    pluripotent    hearts    compartments    chamber    formed    progenitor    atlas    changing    pig    patches    organoids    normal    capitalize    populations    commit    unravel    cellular    embryonic    promise    poorly    chimeric    regulated    conversion    appropriate    3d    devising    dysregulation    disease    differentiation    mimics    hipscs    cardiogenesis    techniques    complemented    stem    realization   

Project "BIOCARD" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN 

Organization address
address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675
website: http://www.med.tu.muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙285˙625 €
 EC max contribution 2˙285˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) coordinator 2˙285˙625.00

Map

 Project objective

The heart is one of the first and most complex organs formed during human embryogenesis. While its anatomy and physiology have been extensively studied over centuries, the normal development of human heart and dysregulation in disease still remain poorly understood at the molecular/cellular level. Stem cell technologies hold promise for modelling development, analysing disease mechanisms, and developing potential therapies. By combining multidisciplinary approaches centred on human induced pluripotent stem cells (hiPSCs), BIOCARD aims at decoding the cellular and molecular principles of human cardiogenesis and developing advanced inter-chimeric human-pig models of cardiac development and disease. State-of-the-art genetic modification techniques and functional genomics will be used to establish a molecular atlas of cell type intermediates of human cardiogenesis in vitro and unravel how their proliferation, differentiation and lineage choice are regulated in health and disease. This in vitro approach will be complemented by detailed analyses of how distinct hiPSC-derived cardiac progenitor populations commit and contribute to specific cardiac compartments in interspecies chimeric hearts in vivo. Finally, we will capitalize on the novel concept that combinations of different well-defined hiPSC-derived cardiac progenitor pools with timely-matched, native extracellular matrix from embryonic hearts will accomplish for the first time the realization of human heart organoids as 3D culture systems of developing heart structures. Clearly, BIOCARD will open game-changing opportunities for devising novel biomedical applications, such as human heart chamber-specific disease modelling, large-scale drug testing in appropriate human 3D cardiac bio-mimics, and regenerative cell therapies based on functional ventricular-muscle patches and direct cell conversion in vivo.

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The information about "BIOCARD" are provided by the European Opendata Portal: CORDIS opendata.

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