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BIOCARD SIGNED

Deep BIOmodeling of human CARDiogenesis

Total Cost €

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EC-Contrib. €

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Partnership

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 BIOCARD project word cloud

Explore the words cloud of the BIOCARD project. It provides you a very rough idea of what is the project "BIOCARD" about.

molecular    culture    embryonic    combining    mimics    hearts    differentiation    cardiogenesis    cell    proliferation    physiology    interspecies    multidisciplinary    chamber    disease    organoids    direct    regenerative    genomics    inter    normal    3d    conversion    regulated    intermediates    changing    embryogenesis    formed    centred    extensively    genetic    stem    game    progenitor    poorly    pig    atlas    centuries    hipsc    analysing    mechanisms    drug    modification    heart    matrix    chimeric    human    combinations    populations    appropriate    biocard    pools    extracellular    principles    techniques    cells    realization    hipscs    structures    dysregulation    commit    matched    ventricular    organs    devising    patches    biomedical    muscle    unravel    therapies    cellular    technologies    time    capitalize    models    native    decoding    bio    lineage    promise    functional    health    complemented    vitro    cardiac    first    anatomy    pluripotent    compartments    hold    vivo   

Project "BIOCARD" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN 

Organization address
address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675
website: http://www.med.tu.muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙285˙625 €
 EC max contribution 2˙285˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) coordinator 2˙285˙625.00

Map

 Project objective

The heart is one of the first and most complex organs formed during human embryogenesis. While its anatomy and physiology have been extensively studied over centuries, the normal development of human heart and dysregulation in disease still remain poorly understood at the molecular/cellular level. Stem cell technologies hold promise for modelling development, analysing disease mechanisms, and developing potential therapies. By combining multidisciplinary approaches centred on human induced pluripotent stem cells (hiPSCs), BIOCARD aims at decoding the cellular and molecular principles of human cardiogenesis and developing advanced inter-chimeric human-pig models of cardiac development and disease. State-of-the-art genetic modification techniques and functional genomics will be used to establish a molecular atlas of cell type intermediates of human cardiogenesis in vitro and unravel how their proliferation, differentiation and lineage choice are regulated in health and disease. This in vitro approach will be complemented by detailed analyses of how distinct hiPSC-derived cardiac progenitor populations commit and contribute to specific cardiac compartments in interspecies chimeric hearts in vivo. Finally, we will capitalize on the novel concept that combinations of different well-defined hiPSC-derived cardiac progenitor pools with timely-matched, native extracellular matrix from embryonic hearts will accomplish for the first time the realization of human heart organoids as 3D culture systems of developing heart structures. Clearly, BIOCARD will open game-changing opportunities for devising novel biomedical applications, such as human heart chamber-specific disease modelling, large-scale drug testing in appropriate human 3D cardiac bio-mimics, and regenerative cell therapies based on functional ventricular-muscle patches and direct cell conversion in vivo.

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The information about "BIOCARD" are provided by the European Opendata Portal: CORDIS opendata.

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