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NiSAN

Voltage Nanosensors for Applications in Neuroscience

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NiSAN project word cloud

Explore the words cloud of the NiSAN project. It provides you a very rough idea of what is the project "NiSAN" about.

democratization    sites    cell    nanosensors    vsnps    understand    investigation    stability    neuroscientists    cross    brightness    internalization    meet    stable    minimal    cells    commercialization    temporal    optically    compatibility    protocols    bilayers    versatile    lipid    goals    nanoscale    insertion    excitation    coating    effort    hence    sensors    brain    particle    imaging    achievement    works    neurons    obtain    commercially    excellent    vsnrs    reproducibility    tool    tuning    aps    convert    ip    record    fine    single    fast    interactions    membrane    nps    neuroscience    shape    multiple    view    invasively    nir    community    sections    sensitivity    types    performance    nanoparticles    reagents    demands    larger    multipurpose    sensing    formulate    poc    insert    self    nvs    mainly    voltage    shift    photobleaching    business    protection    potentials    upscaling    photon    advantages    glp    action    spectral    synthesis    size    lifetime    tools    individual    compositions    nanorods    seek   

Project "NiSAN" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 149˙566 €
 EC max contribution 149˙566 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 149˙566.00

Map

 Project objective

To understand how the brain works, tools need to be developed to allow the investigation of interactions between individual neurons. Towards this goal, We developed voltage sensing nanoparticles (vsNPs) in the shape of nanorods (vsNRs) that self-insert into the cell membrane and could optically record, non-invasively, action potentials (APs) at the single-particle and nanoscale level, at multiple sites, in a large field-of-view. The proposed nanosensors have unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift , fast temporal response, minimal photobleaching, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. In this PoC proposal we seek to convert the NVS program from mainly “R” in R&D effort into “D” effort which will allow for IP protection, commercialization, dissemination, and therefore the ‘democratization’ of the technology to the large community of neuroscientists. In order to convert our achievement to commercially viable reagents business for the neuroscience community via the PoC program, we will (i) identify leading applications in neuroscience and brain research, (ii) improve current technology to meet the applications demands by fine tuning the control over size and shape of the particle and testing various types of coating, testing insertion into different lipid compositions in bilayers and cells, and by testing non-specific internalization, (iii) improve the stability and performance reproducibility of the sensors, (iv) develop methods for upscaling the synthesis of these NPs, (v) and formulate GLP protocols required for commercialization.

Upon achievement of these goals, we will obtain a versatile, stable, multipurpose, novel tool to be implemented in neuroscience.

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The information about "NISAN" are provided by the European Opendata Portal: CORDIS opendata.

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