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NiSAN

Voltage Nanosensors for Applications in Neuroscience

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NiSAN project word cloud

Explore the words cloud of the NiSAN project. It provides you a very rough idea of what is the project "NiSAN" about.

nanoparticles    stability    brain    vsnrs    cells    individual    nvs    glp    convert    seek    insertion    synthesis    view    sensors    nanorods    bilayers    internalization    reproducibility    single    coating    advantages    obtain    tools    meet    sites    cross    size    tool    multipurpose    excellent    temporal    spectral    sensitivity    commercially    protection    photobleaching    investigation    upscaling    fine    vsnps    democratization    insert    nps    mainly    reagents    photon    optically    neuroscience    compositions    membrane    aps    demands    sensing    imaging    cell    nir    community    sections    versatile    particle    compatibility    shape    self    interactions    neuroscientists    nanosensors    types    brightness    record    lipid    stable    neurons    achievement    formulate    action    goals    multiple    tuning    minimal    lifetime    shift    commercialization    business    larger    potentials    understand    poc    invasively    nanoscale    fast    excitation    works    voltage    ip    protocols    hence    effort    performance   

Project "NiSAN" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 149˙566 €
 EC max contribution 149˙566 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 149˙566.00

Map

 Project objective

To understand how the brain works, tools need to be developed to allow the investigation of interactions between individual neurons. Towards this goal, We developed voltage sensing nanoparticles (vsNPs) in the shape of nanorods (vsNRs) that self-insert into the cell membrane and could optically record, non-invasively, action potentials (APs) at the single-particle and nanoscale level, at multiple sites, in a large field-of-view. The proposed nanosensors have unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift , fast temporal response, minimal photobleaching, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. In this PoC proposal we seek to convert the NVS program from mainly “R” in R&D effort into “D” effort which will allow for IP protection, commercialization, dissemination, and therefore the ‘democratization’ of the technology to the large community of neuroscientists. In order to convert our achievement to commercially viable reagents business for the neuroscience community via the PoC program, we will (i) identify leading applications in neuroscience and brain research, (ii) improve current technology to meet the applications demands by fine tuning the control over size and shape of the particle and testing various types of coating, testing insertion into different lipid compositions in bilayers and cells, and by testing non-specific internalization, (iii) improve the stability and performance reproducibility of the sensors, (iv) develop methods for upscaling the synthesis of these NPs, (v) and formulate GLP protocols required for commercialization.

Upon achievement of these goals, we will obtain a versatile, stable, multipurpose, novel tool to be implemented in neuroscience.

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The information about "NISAN" are provided by the European Opendata Portal: CORDIS opendata.

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