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NiSAN

Voltage Nanosensors for Applications in Neuroscience

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NiSAN project word cloud

Explore the words cloud of the NiSAN project. It provides you a very rough idea of what is the project "NiSAN" about.

sensitivity    nanorods    sensing    goals    potentials    particle    formulate    vsnrs    seek    types    achievement    stable    fine    tools    stability    commercially    mainly    membrane    photon    neurons    internalization    works    multipurpose    reproducibility    nanoparticles    demands    nanoscale    protection    sensors    larger    excitation    glp    investigation    cell    temporal    sections    hence    shift    synthesis    self    brightness    action    record    democratization    neuroscience    commercialization    nir    nps    fast    multiple    aps    compatibility    imaging    cross    brain    insertion    coating    poc    nanosensors    shape    versatile    tuning    minimal    insert    view    voltage    lipid    effort    reagents    bilayers    lifetime    meet    size    tool    convert    invasively    community    individual    understand    optically    single    protocols    obtain    sites    photobleaching    ip    vsnps    spectral    performance    neuroscientists    interactions    business    excellent    cells    upscaling    advantages    nvs    compositions   

Project "NiSAN" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 149˙566 €
 EC max contribution 149˙566 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 149˙566.00

Map

 Project objective

To understand how the brain works, tools need to be developed to allow the investigation of interactions between individual neurons. Towards this goal, We developed voltage sensing nanoparticles (vsNPs) in the shape of nanorods (vsNRs) that self-insert into the cell membrane and could optically record, non-invasively, action potentials (APs) at the single-particle and nanoscale level, at multiple sites, in a large field-of-view. The proposed nanosensors have unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift , fast temporal response, minimal photobleaching, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. In this PoC proposal we seek to convert the NVS program from mainly “R” in R&D effort into “D” effort which will allow for IP protection, commercialization, dissemination, and therefore the ‘democratization’ of the technology to the large community of neuroscientists. In order to convert our achievement to commercially viable reagents business for the neuroscience community via the PoC program, we will (i) identify leading applications in neuroscience and brain research, (ii) improve current technology to meet the applications demands by fine tuning the control over size and shape of the particle and testing various types of coating, testing insertion into different lipid compositions in bilayers and cells, and by testing non-specific internalization, (iii) improve the stability and performance reproducibility of the sensors, (iv) develop methods for upscaling the synthesis of these NPs, (v) and formulate GLP protocols required for commercialization.

Upon achievement of these goals, we will obtain a versatile, stable, multipurpose, novel tool to be implemented in neuroscience.

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The information about "NISAN" are provided by the European Opendata Portal: CORDIS opendata.

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