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NiSAN

Voltage Nanosensors for Applications in Neuroscience

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NiSAN project word cloud

Explore the words cloud of the NiSAN project. It provides you a very rough idea of what is the project "NiSAN" about.

record    multipurpose    shape    sections    poc    investigation    glp    temporal    internalization    neuroscientists    self    democratization    cross    mainly    sites    imaging    seek    voltage    lipid    nanoscale    aps    single    insertion    fast    individual    brightness    stable    sensing    vsnps    advantages    excellent    understand    goals    size    brain    hence    photon    versatile    performance    ip    works    protection    excitation    membrane    invasively    vsnrs    synthesis    commercially    convert    formulate    minimal    spectral    types    demands    tuning    shift    nvs    lifetime    optically    effort    neuroscience    potentials    compatibility    nanorods    sensitivity    photobleaching    coating    bilayers    nanoparticles    tools    tool    reproducibility    obtain    view    upscaling    particle    sensors    nps    commercialization    community    meet    interactions    nanosensors    stability    protocols    larger    neurons    reagents    compositions    insert    achievement    cells    business    multiple    cell    action    nir    fine   

Project "NiSAN" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 149˙566 €
 EC max contribution 149˙566 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 149˙566.00

Map

 Project objective

To understand how the brain works, tools need to be developed to allow the investigation of interactions between individual neurons. Towards this goal, We developed voltage sensing nanoparticles (vsNPs) in the shape of nanorods (vsNRs) that self-insert into the cell membrane and could optically record, non-invasively, action potentials (APs) at the single-particle and nanoscale level, at multiple sites, in a large field-of-view. The proposed nanosensors have unique advantages not offered by other methods: much larger voltage sensitivity, high brightness, and hence single-particle voltage sensitivity, large spectral shift , fast temporal response, minimal photobleaching, large two-photon excitation cross sections, excellent performance in the NIR, and compatibility with lifetime imaging. In this PoC proposal we seek to convert the NVS program from mainly “R” in R&D effort into “D” effort which will allow for IP protection, commercialization, dissemination, and therefore the ‘democratization’ of the technology to the large community of neuroscientists. In order to convert our achievement to commercially viable reagents business for the neuroscience community via the PoC program, we will (i) identify leading applications in neuroscience and brain research, (ii) improve current technology to meet the applications demands by fine tuning the control over size and shape of the particle and testing various types of coating, testing insertion into different lipid compositions in bilayers and cells, and by testing non-specific internalization, (iii) improve the stability and performance reproducibility of the sensors, (iv) develop methods for upscaling the synthesis of these NPs, (v) and formulate GLP protocols required for commercialization.

Upon achievement of these goals, we will obtain a versatile, stable, multipurpose, novel tool to be implemented in neuroscience.

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The information about "NISAN" are provided by the European Opendata Portal: CORDIS opendata.

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