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DARWIN SIGNED

Dual capillary waveguide endoscope

Total Cost €

0

EC-Contrib. €

0

Partnership

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 DARWIN project word cloud

Explore the words cloud of the DARWIN project. It provides you a very rough idea of what is the project "DARWIN" about.

tip    idea    modulator    penetration    endoscope    diameter    inserted    sized    speed    transmission    fluorescence    team    compensation    waveguide    detect    bending    preliminary    excitation    scattered    optical    invasively    calibrate    imaging    fibers    generation    darwin    collection    guide    needle    photoacoustic    wave    ratio    ultrasound    mode    fellow    couples    resolution    hydrophone    micron    biological    limiting    configurations    avoiding    matrix    neuron    sound    light    capillary    proof    dual    demonstrated    relies    vivo    cladding    remotely    acoustic    overcome    distal    experiment    cm    detection    attenuation    frequency    act    alternative    tissue    images    display    bossy    explore    prototype    inside    detecting    waves    prof    thin    guiding    scattering    signal    patterns    core    modality    tool    single    outer    device    fiber    absorption    collect    provides    experiments    effect    dispersion    microscopy    illumination   

Project "DARWIN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE GRENOBLE ALPES 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE GRENOBLE ALPES FR (GRENOBLE) coordinator 173˙076.00
2    UNIVERSITE GRENOBLE ALPES FR (SAINT MARTIN D'HERES) coordinator 0.00

Map

 Project objective

Photoacoustic imaging, an emerging multi-wave imaging modality that couples light excitation to acoustic detection via the photoacoustic effect (sound generation via light absorption), relies on detecting ultrasound waves that are very weakly scattered in biological tissue. It provides acoustic-resolution images of optical absorption non-invasively at large depth (up to several cm). However, ultrasound attenuation increases with frequency, limiting the depth-to-resolution ratio to about 100. An alternative to overcome the dispersion of light in tissue due to scattering is using thin, micron-sized diameter optical fibers to both deliver and collect light from the sample. A novel idea and preliminary proof-of-concept experiment has just been demonstrated by Prof. Bossy’s team where a dual waveguide allows also to remotely detect high frequency ultrasound with the same device as that used for guiding light. This device can act both as a multi-mode optical waveguide for the illumination and fluorescence collection using the outer cladding, and as a waveguide to guide the ultrasound out of the tissue using the core, avoiding the absorption by the tissue and increasing the penetration depth.

The overall objective of DARWIN is to study and develop a new type of dual-modality endoscope for optical-resolution photoacoustic and fluorescence microscopy based on a capillary waveguide. To do so, a high speed phase modulator will measure the transmission matrix and calibrate the endoscope providing a way to display any optical patterns at the distal tip. The fellow will explore different configurations where a thin hydrophone, based on a single mode fiber or a needle, is inserted inside the core improving the acoustic signal detection. Furthermore, bending compensation will be investigated. DARWIN will result in a prototype thin endoscope for dual microscopy imaging, an important tool for in-vivo experiments, such as the neuron imaging.

 Publications

year authors and title journal last update
List of publications.
2018 Antonio M. Caravaca-Aguirre, Sakshi Singh, Simon Labouesse, Michael V. Baratta, Rafael Piestun, Emmanuel Bossy
Hybrid photoacoustic/fluorescence microendoscopy through a multimode fiber using speckle illumination
published pages: , ISSN: , DOI:
2020-02-13

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The information about "DARWIN" are provided by the European Opendata Portal: CORDIS opendata.

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