YEAST-TRANS SIGNED
Deciphering the transport mechanisms of small xenobiotic molecules in synthetic yeast cell factories
Total Cost €
0EC-Contrib. €
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Project "YEAST-TRANS" data sheet
The following table provides information about the project.
| Coordinator |
DANMARKS TEKNISKE UNIVERSITET
Organization address contact info |
| Coordinator Country | Denmark [DK] |
| Total cost | 1˙423˙357 € |
| EC max contribution | 1˙423˙357 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-12-01 to 2022-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | DANMARKS TEKNISKE UNIVERSITET | DK (KGS LYNGBY) | coordinator | 1˙423˙357.00 |
Map
Project objective
Industrial biotechnology employs synthetic cell factories to create bulk and fine chemicals and fuels from renewable resources, laying the basis for the future bio-based economy. The major part of the wanted bio-based chemicals are not native to the host cell, such as yeast, i.e. they are xenobiotic. Some xenobiotic compounds are readily secreted by synthetic cells, some are poorly secreted and some are not secreted at all, but how does this transport occur? Or why does it not occur? These fundamental questions remain to be answered and this will have great implications on industrial biotechnology, because improved secretion would bring down the production costs and enable the emergence of novel bio-based products. YEAST-TRANS will fill in this knowledge gap by carrying out the first systematic genome-scale transporter study to uncover the transport mechanisms of small xenobiotic molecules by synthetic yeast cells and to apply this knowledge for engineering more efficient cell factories for bio-based production of fuels and chemicals.
Deliverables
| Data Management Plan | Open Research Data Pilot | 2019-02-26 15:18:56 |
Take a look to the deliverables list in detail: detailed list of YEAST-TRANS deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Behrooz Darbani, Vratislav Stovicek, Steven Axel van der Hoek, Irina Borodina Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae published pages: 201900287, ISSN: 0027-8424, DOI: 10.1073/pnas.1900287116 |
Proceedings of the National Academy of Sciences | 2019-09-11 |
| 2019 |
Steven A. van der Hoek, Behrooz Darbani, Karolina E. Zugaj, Bala Krishna Prabhala, Mathias Bernfried Biron, Milica Randelovic, Jacqueline B. Medina, Douglas B. Kell, Irina Borodina Engineering the yeast Saccharomyces cerevisiae for the production of L-(+)-ergothioneine published pages: , ISSN: , DOI: 10.1101/667592 |
pre-print server | 2019-09-11 |
| 2019 |
Mathew M. Jessopâ€Fabre, Jonathan Dahlin, Mathias B. Biron, Vratislav Stovicek, Birgitta E. Ebert, Lars M. Blank, Itay Budin, Jay D. Keasling, Irina Borodina The Transcriptome and Flux Profiling of Crabtreeâ€Negative Hydroxy Acidâ€Producing Strains of Saccharomyces cerevisiae Reveals Changes in the Central Carbon Metabolism published pages: 1900013, ISSN: 1860-6768, DOI: 10.1002/biot.201900013 |
Biotechnology Journal 14/9 | 2019-09-11 |
| 2019 |
Eko Roy Marella, Jonathan Dahlin, Marie Inger Dam, Jolanda ter Horst, Hanne Bjerre Christensen, Suresh Sudarsan, Guokun Wang, Carina Holkenbrink, Irina Borodina A single-host fermentation process for the production of flavor lactones from non-hydroxylated fatty acids published pages: , ISSN: 1096-7176, DOI: 10.1016/j.ymben.2019.08.009 |
Metabolic Engineering | 2019-09-11 |
| 2018 |
Behrooz Darbani, Douglas B. Kell, Irina Borodina Energetic evolution of cellular Transportomes published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4816-5 |
BMC Genomics 19/1 | 2019-09-02 |
| 2019 |
Irina Borodina Understanding metabolite transport gives an upper hand in strain development published pages: 69-70, ISSN: 1751-7915, DOI: 10.1111/1751-7915.13347 |
Microbial Biotechnology 12/1 | 2019-09-11 |
| 2019 |
Jonathan Dahlin, Carina Holkenbrink, Eko Roy Marella, Guokun Wang, Ulf Liebal, Christian Lieven, Dieter Weber, Douglas McCloskey, Birgitta E. Ebert, Markus J. Herrgård, Lars Mathias Blank, Irina Borodina Multi-Omics Analysis of Fatty Alcohol Production in Engineered Yeasts Saccharomyces cerevisiae and Yarrowia lipolytica published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00747 |
Frontiers in Genetics 10 | 2019-09-11 |
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