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Deciphering the transport mechanisms of small xenobiotic molecules in synthetic yeast cell factories

Total Cost €


EC-Contrib. €






Project "YEAST-TRANS" data sheet

The following table provides information about the project.


Organization address
postcode: 2800

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙423˙357 €
 EC max contribution 1˙423˙357 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Industrial biotechnology employs synthetic cell factories to create bulk and fine chemicals and fuels from renewable resources, laying the basis for the future bio-based economy. The major part of the wanted bio-based chemicals are not native to the host cell, such as yeast, i.e. they are xenobiotic. Some xenobiotic compounds are readily secreted by synthetic cells, some are poorly secreted and some are not secreted at all, but how does this transport occur? Or why does it not occur? These fundamental questions remain to be answered and this will have great implications on industrial biotechnology, because improved secretion would bring down the production costs and enable the emergence of novel bio-based products. YEAST-TRANS will fill in this knowledge gap by carrying out the first systematic genome-scale transporter study to uncover the transport mechanisms of small xenobiotic molecules by synthetic yeast cells and to apply this knowledge for engineering more efficient cell factories for bio-based production of fuels and chemicals.


List of deliverables.
Data Management Plan Open Research Data Pilot 2019-02-26 15:18:56

Take a look to the deliverables list in detail:  detailed list of YEAST-TRANS deliverables.


year authors and title journal last update
List of publications.
2019 Behrooz Darbani, Vratislav Stovicek, Steven Axel van der Hoek, Irina Borodina
Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae
published pages: 201900287, ISSN: 0027-8424, DOI: 10.1073/pnas.1900287116
Proceedings of the National Academy of Sciences 2019-09-11
2019 Steven A. van der Hoek, Behrooz Darbani, Karolina E. Zugaj, Bala Krishna Prabhala, Mathias Bernfried Biron, Milica Randelovic, Jacqueline B. Medina, Douglas B. Kell, Irina Borodina
Engineering the yeast Saccharomyces cerevisiae for the production of L-(+)-ergothioneine
published pages: , ISSN: , DOI: 10.1101/667592
pre-print server 2019-09-11
2019 Mathew M. Jessop‐Fabre, Jonathan Dahlin, Mathias B. Biron, Vratislav Stovicek, Birgitta E. Ebert, Lars M. Blank, Itay Budin, Jay D. Keasling, Irina Borodina
The Transcriptome and Flux Profiling of Crabtree‐Negative Hydroxy Acid‐Producing Strains of Saccharomyces cerevisiae Reveals Changes in the Central Carbon Metabolism
published pages: 1900013, ISSN: 1860-6768, DOI: 10.1002/biot.201900013
Biotechnology Journal 14/9 2019-09-11
2019 Eko Roy Marella, Jonathan Dahlin, Marie Inger Dam, Jolanda ter Horst, Hanne Bjerre Christensen, Suresh Sudarsan, Guokun Wang, Carina Holkenbrink, Irina Borodina
A single-host fermentation process for the production of flavor lactones from non-hydroxylated fatty acids
published pages: , ISSN: 1096-7176, DOI: 10.1016/j.ymben.2019.08.009
Metabolic Engineering 2019-09-11
2018 Behrooz Darbani, Douglas B. Kell, Irina Borodina
Energetic evolution of cellular Transportomes
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4816-5
BMC Genomics 19/1 2019-09-02
2019 Irina Borodina
Understanding metabolite transport gives an upper hand in strain development
published pages: 69-70, ISSN: 1751-7915, DOI: 10.1111/1751-7915.13347
Microbial Biotechnology 12/1 2019-09-11
2019 Jonathan Dahlin, Carina Holkenbrink, Eko Roy Marella, Guokun Wang, Ulf Liebal, Christian Lieven, Dieter Weber, Douglas McCloskey, Birgitta E. Ebert, Markus J. Herrgård, Lars Mathias Blank, Irina Borodina
Multi-Omics Analysis of Fatty Alcohol Production in Engineered Yeasts Saccharomyces cerevisiae and Yarrowia lipolytica
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00747
Frontiers in Genetics 10 2019-09-11

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