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bloodANDbone SIGNED

Blood and bone – conjoined twins in health and disease: bone marrow analogs for hematological and musculoskeletal diseases

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

bloodANDbone project word cloud

Explore the words cloud of the bloodANDbone project. It provides you a very rough idea of what is the project "bloodANDbone" about.

applicability cells multiple strategies screening hematopoietic versatility prerequisite scalability drugs cure kinds surprisingly marrow progression physical events regenerative create onset reciprocal basis biomaterials blood vitro disturbed purpose biochemical disease limitations environment stromal establishing intrinsic treatments natural suitability multipotent treatment simplified balance hematological impaired laden bases diseases understand medicine bone tunable healthy musculoskeletal biological ground maintained mutual macroporous re beings previously closely biomimetic crosstalk metastasis health hscs relationship progeny incidence intertwined breaking mscs stem models mesenchymal human cell capacity capacities hypothesis analog animals influenced tissues myeloma leukemia little paid team

Project "bloodANDbone" data sheet

The following table provides information about the project.

Coordinator	GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER Organization address address: Welfengarten 1 city: HANNOVER postcode: 30167 website: www.uni-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.cell.uni-hannover.de/en/research/department/cell-biology/
Total cost	1˙499˙920 €
EC max contribution	1˙499˙920 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-02-01 to 2023-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER Organization address address: Welfengarten 1 city: HANNOVER postcode: 30167 website: www.uni-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	coordinator	1˙355˙804.00
2	KARLSRUHER INSTITUT FUER TECHNOLOGIE KARLSRUHER INSTITUT FUER TECHNOLOGIE Organization address address: KAISERSTRASSE 12 city: KARLSRUHE postcode: 76131 website: www.kit.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KARLSRUHE)	participant	144˙115.00

Map

Project objective

Blood and bone are closely intertwined. Their intrinsic regenerative capacities are disturbed in many hematological and musculoskeletal diseases. Re-establishing the regenerative potential is the key to cure these diseases by regenerative medicine. Multipotent stem cells of both tissues – hematopoietic stem cells (HSCs) for blood and mesenchymal stem/stromal (MSCs) for bone – are the basis for their regenerative capacity. While it is well established that HSCs are influenced by the bone marrow in their natural environment including MSCs and their progeny, surprisingly little attention has been paid to the reciprocal relationship. The hypothesis of the current proposal is that only when taking both tissues and their mutual crosstalk into account, we will be able to understand how the regenerative potential of blood and bone is impaired in disease and how it can be re-established with novel treatment strategies. For this purpose we need to understand the early events of disease onset and progression. Due to the limitations of such studies in human beings and animals, I propose to develop human in vitro models of healthy bone marrow, which can be induced to develop hematological and musculoskeletal diseases with high incidence, namely leukemia, multiple myeloma and bone metastasis. Previously my team and I developed a simplified bone marrow analog that bases on macroporous, cell-laden biomaterials with tunable physical, biochemical and biological properties. This versatility will enable us to create biomimetic human in vitro models of the human bone marrow in health and disease, which are ground-breaking in their applicability to investigate how the regenerative balance of bone marrow is maintained in health and disturbed in the different kinds of diseases – a prerequisite to develop novel regenerative treatments – as well as their scalability and thus suitability as in vitro test systems for screening of novel drugs or treatments.

Publications

List of publications.
year	authors and title	journal	last update
2019	Annamarija Raic, Frank Friedrich, Domenic Kratzer, Karen Bieback, Joerg Lahann, Cornelia Lee-Thedieck Potential of electrospun cationic BSA fibers to guide osteogenic MSC differentiation via surface charge and fibrous topography published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-56508-6	Scientific Reports 9/1	2020-02-19
2019	Domenic Kratzer, Anita Ludwig-Husemann, Katharina Junges, Udo Geckle, Cornelia Lee-Thedieck Nanostructured Bifunctional Hydrogels as Potential Instructing Platform for Hematopoietic Stem Cell Differentiation published pages: , ISSN: 2296-8016, DOI: 10.3389/fmats.2018.00081	Frontiers in Materials 5	2019-11-18
2019	Annamarija Raic, Toufik Naolou, Anna Mohra, Chandralekha Chatterjee, Cornelia Lee-Thedieck 3D models of the bone marrow in health and disease: yesterday, today, and tomorrow published pages: 37-52, ISSN: 2159-6859, DOI: 10.1557/mrc.2018.203	MRS Communications 9/01	2019-11-18

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The information about "BLOODANDBONE" are provided by the European Opendata Portal: CORDIS opendata.