bloodANDbone SIGNED
Blood and bone – conjoined twins in health and disease: bone marrow analogs for hematological and musculoskeletal diseases
Total Cost €
0EC-Contrib. €
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Project "bloodANDbone" data sheet
The following table provides information about the project.
| Coordinator |
GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | https://www.cell.uni-hannover.de/en/research/department/cell-biology/ |
| Total cost | 1˙499˙920 € |
| EC max contribution | 1˙499˙920 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-02-01 to 2023-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER | DE (HANNOVER) | coordinator | 1˙355˙804.00 |
| 2 | KARLSRUHER INSTITUT FUER TECHNOLOGIE | DE (KARLSRUHE) | participant | 144˙115.00 |
Map
Project objective
Blood and bone are closely intertwined. Their intrinsic regenerative capacities are disturbed in many hematological and musculoskeletal diseases. Re-establishing the regenerative potential is the key to cure these diseases by regenerative medicine. Multipotent stem cells of both tissues – hematopoietic stem cells (HSCs) for blood and mesenchymal stem/stromal (MSCs) for bone – are the basis for their regenerative capacity. While it is well established that HSCs are influenced by the bone marrow in their natural environment including MSCs and their progeny, surprisingly little attention has been paid to the reciprocal relationship. The hypothesis of the current proposal is that only when taking both tissues and their mutual crosstalk into account, we will be able to understand how the regenerative potential of blood and bone is impaired in disease and how it can be re-established with novel treatment strategies. For this purpose we need to understand the early events of disease onset and progression. Due to the limitations of such studies in human beings and animals, I propose to develop human in vitro models of healthy bone marrow, which can be induced to develop hematological and musculoskeletal diseases with high incidence, namely leukemia, multiple myeloma and bone metastasis. Previously my team and I developed a simplified bone marrow analog that bases on macroporous, cell-laden biomaterials with tunable physical, biochemical and biological properties. This versatility will enable us to create biomimetic human in vitro models of the human bone marrow in health and disease, which are ground-breaking in their applicability to investigate how the regenerative balance of bone marrow is maintained in health and disturbed in the different kinds of diseases – a prerequisite to develop novel regenerative treatments – as well as their scalability and thus suitability as in vitro test systems for screening of novel drugs or treatments.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Annamarija Raic, Frank Friedrich, Domenic Kratzer, Karen Bieback, Joerg Lahann, Cornelia Lee-Thedieck Potential of electrospun cationic BSA fibers to guide osteogenic MSC differentiation via surface charge and fibrous topography published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-56508-6 |
Scientific Reports 9/1 | 2020-02-19 |
| 2019 |
Domenic Kratzer, Anita Ludwig-Husemann, Katharina Junges, Udo Geckle, Cornelia Lee-Thedieck Nanostructured Bifunctional Hydrogels as Potential Instructing Platform for Hematopoietic Stem Cell Differentiation published pages: , ISSN: 2296-8016, DOI: 10.3389/fmats.2018.00081 |
Frontiers in Materials 5 | 2019-11-18 |
| 2019 |
Annamarija Raic, Toufik Naolou, Anna Mohra, Chandralekha Chatterjee, Cornelia Lee-Thedieck 3D models of the bone marrow in health and disease: yesterday, today, and tomorrow published pages: 37-52, ISSN: 2159-6859, DOI: 10.1557/mrc.2018.203 |
MRS Communications 9/01 | 2019-11-18 |
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