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bloodANDbone SIGNED

Blood and bone – conjoined twins in health and disease: bone marrow analogs for hematological and musculoskeletal diseases

Total Cost €

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EC-Contrib. €

0

Partnership

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 bloodANDbone project word cloud

Explore the words cloud of the bloodANDbone project. It provides you a very rough idea of what is the project "bloodANDbone" about.

laden    diseases    mscs    capacities    stem    suitability    intrinsic    surprisingly    mutual    ground    cells    understand    capacity    events    stromal    regenerative    leukemia    disturbed    environment    closely    models    disease    hypothesis    balance    cell    limitations    biological    crosstalk    simplified    tunable    kinds    little    physical    influenced    medicine    bases    progression    drugs    cure    metastasis    versatility    progeny    onset    intertwined    impaired    incidence    analog    prerequisite    applicability    natural    create    hematopoietic    myeloma    tissues    breaking    vitro    bone    team    multipotent    re    biochemical    purpose    previously    strategies    human    multiple    animals    beings    screening    establishing    healthy    hscs    biomimetic    treatment    paid    blood    basis    relationship    mesenchymal    scalability    marrow    maintained    reciprocal    biomaterials    hematological    health    macroporous    musculoskeletal    treatments   

Project "bloodANDbone" data sheet

The following table provides information about the project.

Coordinator
GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER 

Organization address
address: Welfengarten 1
city: HANNOVER
postcode: 30167
website: www.uni-hannover.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.cell.uni-hannover.de/en/research/department/cell-biology/
 Total cost 1˙499˙920 €
 EC max contribution 1˙499˙920 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER DE (HANNOVER) coordinator 1˙355˙804.00
2    KARLSRUHER INSTITUT FUER TECHNOLOGIE DE (KARLSRUHE) participant 144˙115.00

Map

 Project objective

Blood and bone are closely intertwined. Their intrinsic regenerative capacities are disturbed in many hematological and musculoskeletal diseases. Re-establishing the regenerative potential is the key to cure these diseases by regenerative medicine. Multipotent stem cells of both tissues – hematopoietic stem cells (HSCs) for blood and mesenchymal stem/stromal (MSCs) for bone – are the basis for their regenerative capacity. While it is well established that HSCs are influenced by the bone marrow in their natural environment including MSCs and their progeny, surprisingly little attention has been paid to the reciprocal relationship. The hypothesis of the current proposal is that only when taking both tissues and their mutual crosstalk into account, we will be able to understand how the regenerative potential of blood and bone is impaired in disease and how it can be re-established with novel treatment strategies. For this purpose we need to understand the early events of disease onset and progression. Due to the limitations of such studies in human beings and animals, I propose to develop human in vitro models of healthy bone marrow, which can be induced to develop hematological and musculoskeletal diseases with high incidence, namely leukemia, multiple myeloma and bone metastasis. Previously my team and I developed a simplified bone marrow analog that bases on macroporous, cell-laden biomaterials with tunable physical, biochemical and biological properties. This versatility will enable us to create biomimetic human in vitro models of the human bone marrow in health and disease, which are ground-breaking in their applicability to investigate how the regenerative balance of bone marrow is maintained in health and disturbed in the different kinds of diseases – a prerequisite to develop novel regenerative treatments – as well as their scalability and thus suitability as in vitro test systems for screening of novel drugs or treatments.

 Publications

year authors and title journal last update
List of publications.
2019 Annamarija Raic, Frank Friedrich, Domenic Kratzer, Karen Bieback, Joerg Lahann, Cornelia Lee-Thedieck
Potential of electrospun cationic BSA fibers to guide osteogenic MSC differentiation via surface charge and fibrous topography
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-56508-6
Scientific Reports 9/1 2020-02-19
2019 Domenic Kratzer, Anita Ludwig-Husemann, Katharina Junges, Udo Geckle, Cornelia Lee-Thedieck
Nanostructured Bifunctional Hydrogels as Potential Instructing Platform for Hematopoietic Stem Cell Differentiation
published pages: , ISSN: 2296-8016, DOI: 10.3389/fmats.2018.00081
Frontiers in Materials 5 2019-11-18
2019 Annamarija Raic, Toufik Naolou, Anna Mohra, Chandralekha Chatterjee, Cornelia Lee-Thedieck
3D models of the bone marrow in health and disease: yesterday, today, and tomorrow
published pages: 37-52, ISSN: 2159-6859, DOI: 10.1557/mrc.2018.203
MRS Communications 9/01 2019-11-18

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The information about "BLOODANDBONE" are provided by the European Opendata Portal: CORDIS opendata.

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