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ELIMINATE SIGNED

Development of strategies to eliminate cancer cells from the bone marrow

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ELIMINATE project word cloud

Explore the words cloud of the ELIMINATE project. It provides you a very rough idea of what is the project "ELIMINATE" about.

treatments    clinical    regulation    strength    cancer    technologies    question    fails    lymphatic    nature    relates    phenotypic    led    informative    suppressed    medical    tumor    molecular    originality    despite    cutting    oncology    stroma    unexplored    line    poses    hypothesis    largely    location    though    ground    shed    grant    anti    mortality    edge    functional    eradicate    generation    cohorts    eliminate    immune    drug    adaptive    models    microenvironment    marrow    conduct    aggressive    survive    successful    expertise    cure    multidisciplinary    insights    rate    bm    strategies    surprisingly    persist    patient    persisting    mechanisms    therapeutic    patients    curable    utmost    sequencing    ongoing    activation    bone    hereby    unresolved    revolution    cellular    lies    innate    unappreciated    candidates    doubles    organ    stage    cells    malignant    health    mouse    innovative    harness    encompassing    prime    breaking    light    profiling    internationally   

Project "ELIMINATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙490˙825 €
 EC max contribution 1˙490˙825 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 1˙490˙825.00

Map

 Project objective

The bone marrow (BM) represents the prime location in which cancer cells survive aggressive treatments. This poses a major health challenge because the mortality rate of patients with curable cancer doubles if tumor cells persist in the BM. One unresolved question is why the immune system fails to eradicate cancer cells from this microenvironment even though it represents a lymphatic organ. Surprisingly, despite the ongoing revolution in immune oncology, the regulation and potential therapeutic activation of the immune response in the BM still remains largely unexplored. In this grant application a new line of research is proposed with the overall objective of understanding the cellular and molecular mechanisms, which control anti-cancer immune responses in the BM. The originality of this proposal relates to the hypothesis that innate and adaptive immune cells are suppressed by stroma cells in the BM. Therefore, we will conduct a comprehensive phenotypic and functional profiling of immune and stroma cells in the BM of cancer patients with and without persisting tumor cells. Based on these insights we will develop novel strategies to harness the immune system to eliminate malignant cells from the BM. The ground-breaking nature of the project is that it will shed light on the unappreciated immune microenvironment in the BM. Its specific strength lies in the multidisciplinary design encompassing informative patient cohorts, state-of-the-art mouse models and cutting-edge technologies including Next-Generation-Sequencing as well as innovative drug candidates. Hereby I can build on my internationally recognized expertise in the BM microenvironment field, which has already led to the successful development of a clinical-stage drug. Novel strategies to eliminate malignant cells from the bone marrow are of utmost medical importance because they would increase the cure rate of cancer patients.

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The information about "ELIMINATE" are provided by the European Opendata Portal: CORDIS opendata.

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