Opendata, web and dolomites

ELIMINATE SIGNED

Development of strategies to eliminate cancer cells from the bone marrow

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ELIMINATE project word cloud

Explore the words cloud of the ELIMINATE project. It provides you a very rough idea of what is the project "ELIMINATE" about.

hereby    strength    line    cutting    grant    largely    multidisciplinary    surprisingly    relates    technologies    candidates    question    expertise    activation    prime    generation    edge    innovative    survive    originality    mouse    stage    anti    health    eradicate    functional    immune    molecular    mechanisms    utmost    organ    despite    clinical    oncology    breaking    treatments    cancer    malignant    patients    medical    curable    insights    eliminate    location    profiling    successful    shed    therapeutic    lymphatic    stroma    unappreciated    doubles    bone    unresolved    hypothesis    lies    bm    tumor    fails    models    poses    led    patient    though    persist    adaptive    internationally    light    cells    conduct    cohorts    phenotypic    drug    aggressive    marrow    cure    microenvironment    cellular    informative    ground    strategies    harness    unexplored    encompassing    persisting    ongoing    regulation    mortality    sequencing    rate    nature    innate    revolution    suppressed   

Project "ELIMINATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙490˙825 €
 EC max contribution 1˙490˙825 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 1˙490˙825.00

Map

 Project objective

The bone marrow (BM) represents the prime location in which cancer cells survive aggressive treatments. This poses a major health challenge because the mortality rate of patients with curable cancer doubles if tumor cells persist in the BM. One unresolved question is why the immune system fails to eradicate cancer cells from this microenvironment even though it represents a lymphatic organ. Surprisingly, despite the ongoing revolution in immune oncology, the regulation and potential therapeutic activation of the immune response in the BM still remains largely unexplored. In this grant application a new line of research is proposed with the overall objective of understanding the cellular and molecular mechanisms, which control anti-cancer immune responses in the BM. The originality of this proposal relates to the hypothesis that innate and adaptive immune cells are suppressed by stroma cells in the BM. Therefore, we will conduct a comprehensive phenotypic and functional profiling of immune and stroma cells in the BM of cancer patients with and without persisting tumor cells. Based on these insights we will develop novel strategies to harness the immune system to eliminate malignant cells from the BM. The ground-breaking nature of the project is that it will shed light on the unappreciated immune microenvironment in the BM. Its specific strength lies in the multidisciplinary design encompassing informative patient cohorts, state-of-the-art mouse models and cutting-edge technologies including Next-Generation-Sequencing as well as innovative drug candidates. Hereby I can build on my internationally recognized expertise in the BM microenvironment field, which has already led to the successful development of a clinical-stage drug. Novel strategies to eliminate malignant cells from the bone marrow are of utmost medical importance because they would increase the cure rate of cancer patients.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ELIMINATE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ELIMINATE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

FunDiT (2019)

Functional Diversity of T cells

Read More