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OMVCRC

Engineered bacterial Outer Membrane Vesicles (OMVs) for colorectal cancer immunotherapy

Total Cost €

EC-Contrib. €

Partnership

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OMVCRC project word cloud

Explore the words cloud of the OMVCRC project. It provides you a very rough idea of what is the project "OMVCRC" about.

omvs clinical concomitant membrane primary outer inhibitor submission infectious prompted cd4 cells antigen mdscs biology cancer scope vaccines scalable originates diseases vesicles models treg crc cancers synergise expressed positive protective tumour decorated cd8 metastatic protection adjuvanticity synthetic bacterial mice demonstration inhibited course innovative correlated setting immunization omv fat1 colorectal erc infiltration engineer ct26 omvac checkpoint immunocompetent purification subcutaneous decrease inhibitors combination

Project "OMVCRC" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI TRENTO Organization address address: VIA CALEPINA 14 city: TRENTO postcode: 38122 website: www.unitn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI TRENTO UNIVERSITA DEGLI STUDI DI TRENTO Organization address address: VIA CALEPINA 14 city: TRENTO postcode: 38122 website: www.unitn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRENTO)	coordinator	93˙750.00
2	FONDAZIONE TOSCANA LIFE SCIENCES FONDAZIONE TOSCANA LIFE SCIENCES Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.toscanalifesciences.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	participant	56˙250.00

Map

Project objective

This proposal originates from recent results obtained in the course of the Advanced ERC Project “OMVac”, the scope of which is to exploit the unique adjuvanticity properties of bacterial Outer Membrane Vesicles (OMVs) for developing innovative vaccines against infectious diseases and cancer. In particular, Synthetic Biology was applied to engineer OMVs with FAT1, a tumour associated antigen expressed in most primary and metastatic colorectal cancers (CRC). Using cancer models in immunocompetent mice, immunization with FAT1-decorated OMVs inhibited subcutaneous growth of FAT1-positive CT26 cancer cells and protection correlated with an increase in tumour infiltration of CD4/CD8 T cells and concomitant decrease of Treg and MDSCs. These promising results prompted the submission of the present proposal which has as main objectives: 1) the demonstration that FAT1-OMV immunization can synergise with the protective activity of checkpoint inhibitors, and 2) the development of a scalable FAT1-OMV production and purification process which could allow testing FAT1-OMV/checkpoint inhibitor combination in the clinical setting.

Publications

List of publications.
year	authors and title	journal	last update
2018	Alberto Grandi, Laura FantappiÃ¨, Carmela Irene, Silvia Valensin, Michele Tomasi, Simone Stupia, Riccardo Corbellari, Elena Caproni, Ilaria Zanella, Samine J. Isaac, Luisa Ganfini, Luca Frattini, Enrico KÃ¶nig, Assunta Gagliardi, Simona Tavarini, Chiara Sammicheli, Matteo Parri, Guido Grandi Vaccination With a FAT1-Derived B Cell Epitope Combined With Tumor-Specific B and T Cell Epitopes Elicits Additive Protection in Cancer Mouse Models published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2018.00481	Frontiers in Oncology 8	2020-01-21

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The information about "OMVCRC" are provided by the European Opendata Portal: CORDIS opendata.