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YinYang SIGNED

Hypothalamic circuits for the selection of defensive and mating behavior in females

Total Cost €

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EC-Contrib. €

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Partnership

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Project "YinYang" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙952˙188 €
 EC max contribution 1˙952˙188 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 1˙952˙188.00

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 Project objective

Social interactions can take different courses depending on the internal state of the participants. For instance, a sexually receptive female mouse will allow a male’s attempt to mount her, but a non-receptive female will fight or flee the same male. Here, we propose to determine how neuronal circuits in the female mouse brain support flexible, state-dependent interactions with male conspecifics. It is known that female receptivity depends on the ventrolateral region of the ventromedial hypothalamus. Within this region there is a population of neurons that expresses receptors for the sex hormone progesterone (PR neurons), whose levels cycle with reproductive state. In pilot experiments, we found that PR neurons are not homogeneous: some respond during receptive behaviors but others respond during defensive or aggressive behaviors. Our main objective is to determine how female hypothalamic PR neurons participate in state-dependent behavioral responses to males. Our hypothesis is that two subpopulations of PR neurons are differentially modulated by the reproductive cycle and that each sub-population activates a different downstream circuit, one specialized for receptive and the other for defensive behaviors. Our specific aims are to: (1) characterize the functional selectivity of individual female PR neurons across the reproductive cycle; (2) map the connectivity of PR neurons to their output targets; (3) test the impact of different PR output pathways by genetically activating and silencing them; and (4) determine how reproductive hormones modulate the synaptic and intrinsic functional properties of PR neurons. These studies will elucidate the neuronal circuit mechanisms of a biologically essential female behavior. More broadly, this work will reveal mechanisms by which neuronal circuits can support flexible state-dependent adaptive behaviors.

 Publications

year authors and title journal last update
List of publications.
2019 Francisco F. Esteves, Diogo Matias, Ana R. Mendes, Bertrand Lacoste, Susana Q. Lima
Sexually dimorphic neuronal inputs to the neuroendocrine dopaminergic system governing prolactin release
published pages: , ISSN: 0953-8194, DOI: 10.1111/jne.12781
Journal of Neuroendocrinology 31/10 2020-01-30

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