Explore the words cloud of the YinYang project. It provides you a very rough idea of what is the project "YinYang" about.
The following table provides information about the project.
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
|Coordinator Country||Portugal [PT]|
|Total cost||1˙952˙188 €|
|EC max contribution||1˙952˙188 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-03-01 to 2023-02-28|
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|1||FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD||PT (LISBOA)||coordinator||1˙952˙188.00|
Social interactions can take different courses depending on the internal state of the participants. For instance, a sexually receptive female mouse will allow a male’s attempt to mount her, but a non-receptive female will fight or flee the same male. Here, we propose to determine how neuronal circuits in the female mouse brain support flexible, state-dependent interactions with male conspecifics. It is known that female receptivity depends on the ventrolateral region of the ventromedial hypothalamus. Within this region there is a population of neurons that expresses receptors for the sex hormone progesterone (PR neurons), whose levels cycle with reproductive state. In pilot experiments, we found that PR neurons are not homogeneous: some respond during receptive behaviors but others respond during defensive or aggressive behaviors. Our main objective is to determine how female hypothalamic PR neurons participate in state-dependent behavioral responses to males. Our hypothesis is that two subpopulations of PR neurons are differentially modulated by the reproductive cycle and that each sub-population activates a different downstream circuit, one specialized for receptive and the other for defensive behaviors. Our specific aims are to: (1) characterize the functional selectivity of individual female PR neurons across the reproductive cycle; (2) map the connectivity of PR neurons to their output targets; (3) test the impact of different PR output pathways by genetically activating and silencing them; and (4) determine how reproductive hormones modulate the synaptic and intrinsic functional properties of PR neurons. These studies will elucidate the neuronal circuit mechanisms of a biologically essential female behavior. More broadly, this work will reveal mechanisms by which neuronal circuits can support flexible state-dependent adaptive behaviors.
|year||authors and title||journal||last update|
Francisco F. Esteves, Diogo Matias, Ana R. Mendes, Bertrand Lacoste, Susana Q. Lima
Sexually dimorphic neuronal inputs to the neuroendocrine dopaminergic system governing prolactin release
published pages: , ISSN: 0953-8194, DOI: 10.1111/jne.12781
|Journal of Neuroendocrinology 31/10||2020-01-30|
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