ForceMorph SIGNED
The integration of cell signalling and mechanical forces in vascular morphology
Total Cost €
0EC-Contrib. €
0Partnership
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0ForceMorph project word cloud
Explore the words cloud of the ForceMorph project. It provides you a very rough idea of what is the project "ForceMorph" about.
Project "ForceMorph" data sheet
The following table provides information about the project.
| Coordinator |
ABO AKADEMI
Organization address contact info |
| Coordinator Country | Finland [FI] |
| Total cost | 1˙919˙599 € |
| EC max contribution | 1˙919˙599 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-03-01 to 2023-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ABO AKADEMI | FI (ABO) | coordinator | 1˙037˙012.00 |
| 2 | TECHNISCHE UNIVERSITEIT EINDHOVEN | NL (EINDHOVEN) | participant | 882˙586.00 |
Map
Project objective
Cardiovascular diseases represent the principal worldwide medical challenge of the 21st century (WHO), and new concepts to treat, predict and even prevent these diseases are needed. Structural remodelling of the vasculature in response to changes in blood flow is important to maintain mechanical homeostasis, and many diseases are related to defects in tissue morphology and mechanical imbalance. Signalling between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) via the Notch pathway regulates the morphology and structural remodelling of the arterial wall. Importantly, Notch offers handles for therapeutic control and thus opportunities for treatment of malformation and adaptation. However, we lack the essential understanding of how hemodynamic forces integrate with Notch signalling to rationally and responsibly target Notch in vascular therapies. The complexity of the problem requires new tools and an interdisciplinary approach. Our project integrates engineering, computational modelling, with cell biology and in vivo model systems to address the question. In vivo models will validate the in in vitro model systems to ensure that they are reproducible and reflect the reality. Through this integrated approach we will enable new therapeutic developments.
The specific objectives of the project are to:
1) Study EC-VSMC signalling real time, at high resolution by a novel biomimetic 4D Artery-on-Chip that recapitulates the cell-composition, -organisation and hemodynamic forces of the physiological artery
2) Develop a computational model of the arterial wall that include the mechanosensitivity of Notch signalling to predict how the complex interactions affect arterial morphology and remodelling
3) Use in vivo animal models to elucidate how regulation of Notch signalling affects tissue morphology and remodelling in response to changes in hemodynamic conditions
Deliverables
| Data management plan | Open Research Data Pilot | 2019-11-18 10:14:50 |
Take a look to the deliverables list in detail: detailed list of ForceMorph deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Nicole C. A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika Sjöqvist, Carlijn V. C. Bouten, John E. Eriksson, Cecilia M. Sahlgren Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-48218-w |
Scientific Reports 9/1 | 2019-10-14 |
| 2018 |
L. A. Tiemeijer, J-P. Frimat, O. M. J. A. Stassen, C. V. C. Bouten, C. M. Sahlgren Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24646-y |
Scientific Reports 8/1 | 2019-05-08 |
| 2018 |
Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis published pages: E3682-E3691, ISSN: 0027-8424, DOI: 10.1073/pnas.1715277115 |
Proceedings of the National Academy of Sciences 115/16 | 2019-09-13 |
| 2018 |
Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis published pages: E3682-E3691, ISSN: 0027-8424, DOI: 10.1073/pnas.1715277115 |
Proceedings of the National Academy of Sciences 115/16 | 2019-05-08 |
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