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ToCCaTa SIGNED

Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ToCCaTa project word cloud

Explore the words cloud of the ToCCaTa project. It provides you a very rough idea of what is the project "ToCCaTa" about.

tumor    tissue    pleiotropic    phenotypes    supporting    induction    activated    cells    limited    lung    equipped    anticipate    safe    gene    systematic    combination    optimized    enormous    functions    autoimmunity    interventions    anti    treating    resting    capacity    experimental    generation    prophylactic    therapeutic    cell    immunotherapy    disease    expression    chronic    contrasting    screening    foundation    particularities    augment    resident    pathogen    adjusted    vaccine    qualitative    function    immunotherapies    malignant    hypo    thought    performing    customized    discovery    memory    interventional    acute    liver    equally    fulfil    solutions    obstacle    viral    single    strategies    cd8    aggressive    proliferative    utilizing    hypothesis    molecular    infections    optimize    of    instance    similarly    translate    comprehension    effector    attenuate    seek    tumors    immunity    mimic    functional    protection    diversity    overcome    cytotoxic    significantly    exhausted    diseases    advantage    fulminant    stage    alter    mechanisms    vital    immunopathology   

Project "ToCCaTa" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙850 €
 EC max contribution 1˙999˙850 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙999˙850.00

Map

 Project objective

Cytotoxic T cells have enormous potential for prophylactic and therapeutic interventions against problematic acute or chronic infections and against malignant tumors. A major obstacle to utilizing them effectively is our limited understanding of the molecular foundation that is necessary for CD8 T cells to fulfil their pleiotropic functions. Equally important is to find solutions supporting the robust and safe induction of large numbers of pathogen- or tumor-specific T cells and strategies for customized generation of T cells equipped with a functional capacity that are optimized to the often contrasting needs of particular diseases. For instance, anti-tumor immunity requires large numbers of highly activated effector T cells, while resting memory cells with high proliferative potential in combination with tissue-resident memory cells are thought to enhance protection against viral infections. Similarly, the challenge in treating chronic infections and tumors is to overcome the hypo-functional “exhausted” stage of T cells, but therapeutic induction of the same mechanisms to attenuate an aggressive T cell response could be vital for treating autoimmunity or immunopathology in fulminant liver or lung infections. Thus, to develop prophylactic or interventional strategies through which qualitative aspects of T cell function can be adjusted is a current key challenge in the immunotherapy and vaccine field. We seek to promote such activities by performing research that aims to significantly augment our comprehension of how molecular particularities translate into functional diversity. By taking advantage of 1) experimental systems that specifically mimic disease relevant T cell phenotypes, 2) approaches to assess molecular diversity at single cell level, 3) effective strategies to alter gene expression, and 4) systematic and hypothesis-driven molecular screening, we anticipate the discovery of new targets to optimize immunotherapies for tumors and chronic infections.

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The information about "TOCCATA" are provided by the European Opendata Portal: CORDIS opendata.

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