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Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

Total Cost €


EC-Contrib. €






 ToCCaTa project word cloud

Explore the words cloud of the ToCCaTa project. It provides you a very rough idea of what is the project "ToCCaTa" about.

safe    performing    diversity    obstacle    diseases    thought    discovery    experimental    of    combination    aggressive    limited    treating    viral    capacity    systematic    supporting    solutions    equipped    adjusted    mechanisms    optimized    therapeutic    stage    significantly    resting    proliferative    cytotoxic    pathogen    attenuate    vaccine    translate    chronic    autoimmunity    seek    tumors    screening    optimize    activated    memory    molecular    resident    effector    anticipate    strategies    interventions    immunopathology    phenotypes    infections    comprehension    foundation    contrasting    advantage    liver    vital    exhausted    enormous    fulminant    induction    instance    function    interventional    immunotherapies    pleiotropic    mimic    hypothesis    single    alter    qualitative    immunotherapy    functional    functions    anti    cells    cell    disease    augment    acute    gene    utilizing    lung    immunity    hypo    equally    generation    prophylactic    tumor    overcome    similarly    expression    customized    protection    tissue    malignant    cd8    fulfil    particularities   

Project "ToCCaTa" data sheet

The following table provides information about the project.


Organization address
address: Arcisstrasse 21
postcode: 80333

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙850 €
 EC max contribution 1˙999˙850 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cytotoxic T cells have enormous potential for prophylactic and therapeutic interventions against problematic acute or chronic infections and against malignant tumors. A major obstacle to utilizing them effectively is our limited understanding of the molecular foundation that is necessary for CD8 T cells to fulfil their pleiotropic functions. Equally important is to find solutions supporting the robust and safe induction of large numbers of pathogen- or tumor-specific T cells and strategies for customized generation of T cells equipped with a functional capacity that are optimized to the often contrasting needs of particular diseases. For instance, anti-tumor immunity requires large numbers of highly activated effector T cells, while resting memory cells with high proliferative potential in combination with tissue-resident memory cells are thought to enhance protection against viral infections. Similarly, the challenge in treating chronic infections and tumors is to overcome the hypo-functional “exhausted” stage of T cells, but therapeutic induction of the same mechanisms to attenuate an aggressive T cell response could be vital for treating autoimmunity or immunopathology in fulminant liver or lung infections. Thus, to develop prophylactic or interventional strategies through which qualitative aspects of T cell function can be adjusted is a current key challenge in the immunotherapy and vaccine field. We seek to promote such activities by performing research that aims to significantly augment our comprehension of how molecular particularities translate into functional diversity. By taking advantage of 1) experimental systems that specifically mimic disease relevant T cell phenotypes, 2) approaches to assess molecular diversity at single cell level, 3) effective strategies to alter gene expression, and 4) systematic and hypothesis-driven molecular screening, we anticipate the discovery of new targets to optimize immunotherapies for tumors and chronic infections.

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The information about "TOCCATA" are provided by the European Opendata Portal: CORDIS opendata.

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