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ToCCaTa SIGNED

Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ToCCaTa project word cloud

Explore the words cloud of the ToCCaTa project. It provides you a very rough idea of what is the project "ToCCaTa" about.

activated    stage    expression    autoimmunity    experimental    hypo    pathogen    aggressive    diversity    malignant    tumors    cells    liver    supporting    cytotoxic    thought    instance    induction    cell    mimic    vaccine    enormous    similarly    hypothesis    alter    comprehension    contrasting    effector    single    limited    tumor    disease    fulminant    immunotherapies    prophylactic    fulfil    chronic    particularities    cd8    resident    utilizing    vital    adjusted    foundation    significantly    obstacle    of    anti    solutions    safe    exhausted    treating    optimize    molecular    diseases    equally    qualitative    seek    optimized    functional    pleiotropic    mechanisms    acute    gene    function    strategies    resting    attenuate    interventions    equipped    interventional    systematic    advantage    immunopathology    combination    viral    therapeutic    proliferative    immunity    protection    lung    immunotherapy    phenotypes    discovery    augment    tissue    memory    capacity    infections    anticipate    translate    customized    functions    overcome    performing    generation    screening   

Project "ToCCaTa" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙850 €
 EC max contribution 1˙999˙850 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙999˙850.00

Map

 Project objective

Cytotoxic T cells have enormous potential for prophylactic and therapeutic interventions against problematic acute or chronic infections and against malignant tumors. A major obstacle to utilizing them effectively is our limited understanding of the molecular foundation that is necessary for CD8 T cells to fulfil their pleiotropic functions. Equally important is to find solutions supporting the robust and safe induction of large numbers of pathogen- or tumor-specific T cells and strategies for customized generation of T cells equipped with a functional capacity that are optimized to the often contrasting needs of particular diseases. For instance, anti-tumor immunity requires large numbers of highly activated effector T cells, while resting memory cells with high proliferative potential in combination with tissue-resident memory cells are thought to enhance protection against viral infections. Similarly, the challenge in treating chronic infections and tumors is to overcome the hypo-functional “exhausted” stage of T cells, but therapeutic induction of the same mechanisms to attenuate an aggressive T cell response could be vital for treating autoimmunity or immunopathology in fulminant liver or lung infections. Thus, to develop prophylactic or interventional strategies through which qualitative aspects of T cell function can be adjusted is a current key challenge in the immunotherapy and vaccine field. We seek to promote such activities by performing research that aims to significantly augment our comprehension of how molecular particularities translate into functional diversity. By taking advantage of 1) experimental systems that specifically mimic disease relevant T cell phenotypes, 2) approaches to assess molecular diversity at single cell level, 3) effective strategies to alter gene expression, and 4) systematic and hypothesis-driven molecular screening, we anticipate the discovery of new targets to optimize immunotherapies for tumors and chronic infections.

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The information about "TOCCATA" are provided by the European Opendata Portal: CORDIS opendata.

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