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inhibitAUTO TERMINATED

Towards a New Frontier in Autophagy Inhibition: The Development of a Novel Class of ChemicalProbes and Identification of Their Associated Biological Target

Total Cost €

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EC-Contrib. €

0

Partnership

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 inhibitAUTO project word cloud

Explore the words cloud of the inhibitAUTO project. It provides you a very rough idea of what is the project "inhibitAUTO" about.

validation    structure    probes    pioneering    implications    holistic    provides    chemical    ambition    mode    potency    career    systematic    newest    cancer    lab    chemistry    sp2    investigations    dissect    technologies    engagement    me    fellowship    researcher    identification    quality    scaffold    interrogate    combines    potentially    cell    initiate    assays    collection    scientific    reaction    biology    linked    academic    inhibitors    biological    inhibitory    vital    opportunity    sp3    discover    unknown    huge    autophagic    active    biophysical    action    science    preparation    healthcare    exploration    synthetic    relationship    newly    host    rationalised    biomedical    class    gt    cross    druggable    autophagy    broad    therapeutics    variation    druggability    intrinsically    independent    compound    coupling    protein    potent    phenotypic    classes    prepared    selective    modulates    establishing    proteins    improvement    dysregulation    compounds    significance   

Project "inhibitAUTO" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.mpi-dortmund.mpg.de/institute/directors/herbert-waldmann
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

This action aims to discover a novel class of autophagy inhibitors and newly develop chemical probes that can identify their protein targets and dissect their biological mode of action. Autophagy dysregulation is intrinsically linked with major European healthcare challenges, including cancer. The identification of new classes of druggable autophagic proteins will have broad implications for the development of novel and more effective cancer therapeutics. To address the aims of this action, this proposal seeks support to initiate a pioneering and holistic chemical biology programme, which combines the newest technologies in synthetic chemistry and cell biology. Phenotypic investigations in the host lab recently identified new inhibitors of autophagy based on a novel scaffold, which modulates autophagy through an exciting but unknown pathway. In this action the use of a newly introduced sp2-sp3 cross-coupling reaction will allow systematic variation of the scaffold, exploration of its structure-activity relationship, and improvement of the potency of these inhibitors to facilitate the preparation of high-quality chemical probes. A focused compound collection (>100 compounds) will be prepared and investigated in cell-based assays, with the aim of establishing a broad, potent and selective class of inhibitors. The inhibitory mode of action will then be rationalised through identification, validation and engagement of the associated biological targets using further cell-based investigations and biophysical assays. Chemical probes will be generated from the most active inhibitors and used to identify and interrogate the druggability of a novel protein target with potentially huge significance for biomedical science. My ambition is to become an independent academic researcher in chemical biology at a leading European institution, and this Fellowship provides a vital opportunity for me to advance my scientific and career potential.

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The information about "INHIBITAUTO" are provided by the European Opendata Portal: CORDIS opendata.

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