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inhibitAUTO TERMINATED

Towards a New Frontier in Autophagy Inhibition: The Development of a Novel Class of ChemicalProbes and Identification of Their Associated Biological Target

Total Cost €

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EC-Contrib. €

0

Partnership

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 inhibitAUTO project word cloud

Explore the words cloud of the inhibitAUTO project. It provides you a very rough idea of what is the project "inhibitAUTO" about.

linked    provides    investigations    chemistry    coupling    therapeutics    vital    implications    technologies    druggable    researcher    gt    intrinsically    sp2    interrogate    newest    phenotypic    broad    pioneering    engagement    chemical    inhibitors    collection    selective    relationship    healthcare    compound    autophagic    ambition    establishing    class    compounds    exploration    discover    reaction    cell    opportunity    newly    potency    host    preparation    unknown    autophagy    cross    me    structure    biology    mode    classes    biological    inhibitory    proteins    dissect    combines    lab    holistic    synthetic    active    potent    scaffold    scientific    rationalised    modulates    initiate    cancer    protein    druggability    potentially    assays    independent    identification    improvement    systematic    variation    fellowship    sp3    validation    quality    significance    biophysical    science    prepared    biomedical    probes    action    huge    academic    dysregulation    career   

Project "inhibitAUTO" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.mpi-dortmund.mpg.de/institute/directors/herbert-waldmann
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

This action aims to discover a novel class of autophagy inhibitors and newly develop chemical probes that can identify their protein targets and dissect their biological mode of action. Autophagy dysregulation is intrinsically linked with major European healthcare challenges, including cancer. The identification of new classes of druggable autophagic proteins will have broad implications for the development of novel and more effective cancer therapeutics. To address the aims of this action, this proposal seeks support to initiate a pioneering and holistic chemical biology programme, which combines the newest technologies in synthetic chemistry and cell biology. Phenotypic investigations in the host lab recently identified new inhibitors of autophagy based on a novel scaffold, which modulates autophagy through an exciting but unknown pathway. In this action the use of a newly introduced sp2-sp3 cross-coupling reaction will allow systematic variation of the scaffold, exploration of its structure-activity relationship, and improvement of the potency of these inhibitors to facilitate the preparation of high-quality chemical probes. A focused compound collection (>100 compounds) will be prepared and investigated in cell-based assays, with the aim of establishing a broad, potent and selective class of inhibitors. The inhibitory mode of action will then be rationalised through identification, validation and engagement of the associated biological targets using further cell-based investigations and biophysical assays. Chemical probes will be generated from the most active inhibitors and used to identify and interrogate the druggability of a novel protein target with potentially huge significance for biomedical science. My ambition is to become an independent academic researcher in chemical biology at a leading European institution, and this Fellowship provides a vital opportunity for me to advance my scientific and career potential.

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The information about "INHIBITAUTO" are provided by the European Opendata Portal: CORDIS opendata.

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