Opendata, web and dolomites


RNA Sprays as a Tool for Crop Improvement and Protection

Total Cost €


EC-Contrib. €






 RNASTIP project word cloud

Explore the words cloud of the RNASTIP project. It provides you a very rough idea of what is the project "RNASTIP" about.

solutions    activation    biochemistry    efficient    worldwide    combat    sequestering    protect    sprayed    toxic    rendered    diverse    security    heightened    downregulate    demand    biology    nature    pressure    gmos    carrier    global    regulators    obsolete    candidate    mirna    population    micro    gmo    employment    crop    vegetable    line    public    cheap    genetically    extensive    combination    modified    raised    spraying    conjugating    whereas    inactivating    mycology    tomato    organisms    world    transgenic    tested    decoying    agrochemicals    crops    molecular    plants    sustainable    virology    protection    compounds    solely    breeding    plant    selectively    rna    agriculture    microbiology    solanum    strategy    optimizing    lycopersicum    tools    training    point    food    direction    upregulate    entomology    agricultural    improvement    rnas    with    scientific    cells    sprays    interference    free    environmentally    genes    stability    transfer    dicot    farmland    pests    rnaa    activate    host    multidisciplinary    modify    rnai    considerable   

Project "RNASTIP" data sheet

The following table provides information about the project.


Organization address
city: VOLOS
postcode: 38221

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 164˙653 €
 EC max contribution 164˙653 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PANEPISTIMIO THESSALIAS EL (VOLOS) coordinator 164˙653.00


 Project objective

With the increasing world population, reduced farmland and demand for heightened global food security, comes the need for new sustainable, effective and environmentally friendly agricultural solutions. The extensive use of toxic agrochemicals has been rendered obsolete, whereas the employment of transgenic plants and genetically modified organisms (GMOs) has raised considerable public and scientific concerns. The current proposal aims to develop GMO-free tools to modify and protect crops based solely on RNA sprays. The candidate has recently developed a simple, cheap and efficient method for RNA delivery into plant cells by high pressure spraying. Using this method, we now aim to develop RNA sprays to selectively downregulate (RNA interference, RNAi) and upregulate (RNA activation, RNAa) genes involved in crop protection and improvement. In the current proposal, we will focus on tomato (Solanum lycopersicum), one of the most important dicot vegetable crops worldwide. On the one hand, through RNAi sprays, we will aim to combat some of tomato's most important and diverse pests by inactivating crucial for their development genes. On the other hand, through RNAa sprays, we will try to activate selected tomato genes by decoying and sequestering their micro RNA (miRNA) regulators. Methods for optimizing the stability of sprayed RNAs into plant cells for field condition applications by conjugating them to carrier compounds will be tested. The multidisciplinary nature of the project is strong, involving a combination of molecular biology, microbiology, plant biology, virology, mycology, entomology and biochemistry. This proposal includes the transfer of knowledge to the host institute and the training of the candidate. Expected results will point towards a new direction of GMO-free plant breeding tools, in line with the EU strategy for sustainable agriculture.


year authors and title journal last update
List of publications.
2019 Athanasios Dalakouras
Double stranded RNAs: future\'s molecular insecticides.(Translation of the original Greek title: Δίκλωνα RNA: τα μοριακά εντομοκτόνα του μέλλοντος)
published pages: 1-7, ISSN: , DOI:
Hellenic Entomological Society 2020-01-29
2019 Athanasios Dalakouras, Michael Wassenegger, Elena Dadami, Ioannis Ganopoulos, Maria Pappas, Kalliope K Papadopoulou
GMO-free RNAi: exogenous application of RNA molecules in plants.
published pages: pp.00570.2019, ISSN: 0032-0889, DOI: 10.1104/pp.19.00570
Plant Physiology 2020-01-29

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The information about "RNASTIP" are provided by the European Opendata Portal: CORDIS opendata.

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