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Opendata, web and dolomites

MaGMa SIGNED

Applying Metabolomics to Unveil follow-up treatment biomarkers and Identify Novel TherapeuticTargets in Glioblastoma

Total Cost €

EC-Contrib. €

Partnership

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MaGMa project word cloud

Explore the words cloud of the MaGMa project. It provides you a very rough idea of what is the project "MaGMa" about.

therapeutic evs tumour fingerprint form metabolic gbm differential vesicles self metabolomic biology believe packaged brain translation metabolites fresh besides released biomarkers tissues tumorigenic initiation treatment human altered patients treatments isolated cure last map possibility subtypes alterations copy function ev personalized surgical efficacy diagnosis model drugs made period glioma extreme profiles elucidate hallmark surrounding cscs cells resistance prognosis therapies origins effort clinical mesenchymal phenotypic adapt will observations profile cancer phenotypes survival stem containing extracellular patterns metabolite epigenetic metabolome distinguishing devastating metabolism malignant multiforme tissue glioblastoma mutations necessities cancerous link renewing proneural generating

Project "MaGMa" data sheet

The following table provides information about the project.

Coordinator	FUNDACION UNIVERSITARIA SAN PABLO-CEU Organization address address: C ISAAC PERAL 58 city: MADRID postcode: 28040 website: www.ceu.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-04-04 to 2020-04-03

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACION UNIVERSITARIA SAN PABLO-CEU FUNDACION UNIVERSITARIA SAN PABLO-CEU Organization address address: C ISAAC PERAL 58 city: MADRID postcode: 28040 website: www.ceu.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	158˙121.00

Map

Project objective

Glioblastoma multiforme (GBM) is the most common and devastating form of malignant brain tumour, containing self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumour initiation and therapeutic resistance. The survival of such patients has not improved so much in the last 60 years, and we are still far to get any cure. Therefore, new methods for prognosis and diagnosis are needed, and it could come from better understanding of glioma biology. The link between cancer and altered metabolism is not new. Many observations were made during the early period of cancer biology research, identifying metabolic changes as a common feature of cancerous tissues to adapt to the necessities of the tumour. GBM comprises several phenotypic subtypes, each with distinguishing hallmark mutations, copy number alterations, epigenetic alterations, and clinical features, generating a different treatment efficacy. We believe that GBM subtypes will produce different patterns in the metabolite fingerprint and moreover the use of treatments will change them. In the present project we will use a metabolomic approach on a model of human CSCs isolated from fresh surgical tissue, to characterize two of the most extreme phenotypes; proneural and mesenchymal. We will map the tumour metabolite profile and the translation of this knowledge may lead to more personalized therapies. Besides that, we are interested in studying the metabolite profile of the extracellular vesicles (EV) released by those subtypes. This research effort is not only necessary to map the metabolome of EVs from different origins, but also to elucidate whether or not the metabolites are directly packaged into specific EVs, their possible function in surrounding cells, as the possibility of finding different metabolite profiles characteristic of tumour subtypes and moreover with a differential response to drugs that could be use as biomarkers.

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The information about "MAGMA" are provided by the European Opendata Portal: CORDIS opendata.