Opendata, web and dolomites

SEG SIGNED

Anatomical and functional characterization of the neural circuits controlling ejaculation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "SEG" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 160˙635 €
 EC max contribution 160˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-02-25   to  2022-06-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 160˙635.00

Map

 Project objective

Sexual behavior is fundamental for evolution and an important component of human well-being. Ejaculation is a critical mechanism in male sexual function, which is hypothesized to be controlled by a neural circuit known as the 'spinal ejaculation generator' (SEG), located in the lumbar spinal cord. The SEG has also been hypothesized to control the post-ejaculatory refractory period, a phase of sexual satiety, through ascending projections to the brain. However, the mechanisms by which the SEG controls ejaculation and the refractory remain elusive. We will tackle this problem first by using anatomical tracing to find the spinal neurons that provide input to the ejaculatory muscles and immunochemistry to characterize their molecular identity. We will use this information to provide specific genetic access to SEG neurons. By expressing fluorescent probes in these neurons, we will be able to obtain targeted electrophysiological recordings and use them to characterize the intrinsic and synaptic properties of the SEG circuitry in vivo. By expressing genetically encoded calcium indicators, which provide fluorescence probes of activity, we will monitor the activity of the SEG during sexual behaviour. Finally, by expressing and optically stimulating excitatory and inhibitory opsins in SEG neurons or their terminals, we will test their causal role in triggering both ejaculation and the post-ejaculatory refractory period. This project will provide the first mechanistic description of the key neural circuitry controlling male ejaculation and the refractory period, with potential implications for the treatment of sexual dysfunction.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SEG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SEG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

FOCUSIS (2020)

Focal volume Control Using Structured Illumination Sources

Read More  

ToMComputations (2019)

How other minds are represented in the human brain: Neural computations underlying Theory of Mind

Read More  

MIGPSC (2018)

Shaping the European Migration Policy: the role of the security industry

Read More  
lastchecktime (2022-08-18 23:46:51) correctly updated