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BETTER-B SIGNED

BETTER TREATMENTS FOR BREATHLESSNESS IN PALLIATIVE AND END OF LIFE CARE

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BETTER-B project word cloud

Explore the words cloud of the BETTER-B project. It provides you a very rough idea of what is the project "BETTER-B" about.

uk    disease    distresses    accessible    cb    society    reviews    widest    interstitial    feasibility    needing    suggest    treatment    antidepressant    quality    despite    persists    clinicians    statisticians    patient    ild    respiratory    disciplinary    medicines    care    community    emergency    versus    services    recruits    germany    clinician    18    trialists    group    economists    trial    operation    health    carers    friends    pulmonary    treating    detrimental    clinical    family    caregivers    frightening    sustained    geriatric    obstructive    blind    optimal    psychosocial    lung    symptom    unites    placebo    patients    breathlessness    licenced    ensures    refractory    poland    tests    alongside    double    randomised    offers    groups    medicine    internationally    time    mirtazapine    wellbeing    survey    world    chronic    palliative    rehabilitation    morbidity    guidance    underlying    purpose    reduce    scientists    conduct    life    italy    copd    months    ireland    physical    324   

Project "BETTER-B" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 3˙791˙503 €
 EC max contribution 3˙769˙999 € (99%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 1˙395˙122.00
2    UNIVERSITY OF LEEDS UK (LEEDS) participant 669˙111.00
3    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 476˙203.00
4    AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA IT (REGGIO EMILIA) participant 283˙960.00
5    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 230˙812.00
6    KLINIKUM DER UNIVERSITAET ZU KOELN DE (KOELN) participant 170˙383.00
7    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) participant 109˙671.00
8    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) participant 106˙095.00
9    GDANSKI UNIWERSYTET MEDYCZNY PL (GDANSK) participant 97˙612.00
10    UNIVERSITA CATTOLICA DEL SACRO CUORE IT (MILANO) participant 88˙987.00
11    UNIWERSYTET MIKOLAJA KOPERNIKA W TORUNIU PL (TORUN) participant 76˙290.00
12    EUROPEAN RESPIRATORY SOCIETY CH (LAUSANNE) participant 65˙750.00
13    UNIVERSITY OF TECHNOLOGY SYDNEY AU (SYDNEY) participant 0.00

Map

 Project objective

The BETTER-B consortium tests whether mirtazapine, currently used as an antidepressant, is an effective treatment to reduce chronic or refractory breathlessness (CB) in patients with advanced chronic obstructive pulmonary or interstitial lung disease (COPD or ILD) needing palliative care or at the end of life.

Our focus is on breathlessness that persists despite optimal treatment of the underlying condition. This widespread and frightening symptom has a major detrimental impact on patients’ quality of life and distresses their family, friends and carers. It is associated with physical and psychosocial morbidity and results in high use of health care services, including emergency care.

There are no licenced medicines for CB in the world. It is a major challenge to clinical management, care quality and patient wellbeing. We have completed a feasibility trial in 60 patients, reviews and case studies that suggest mirtazapine is a promising treatment.

To assess if mirtazapine is effective, we conduct a randomised double blind clinical trial of mirtazapine versus placebo in patients with CB and COPD or ILD. The trial recruits 324 patients over 18 months across respiratory, palliative care and community services in Poland, Ireland, Italy, Germany and the UK. We study the effects of treatment over time on patients, their family or caregivers and care costs. We survey clinicians and produce accessible European guidance on treating CB.

The consortium unites a unique multi-disciplinary group of clinician scientists from respiratory, palliative, geriatric and rehabilitation fields, alongside statisticians, trialists, health economists, health care researchers, patient and consumer groups and a European Society. This ensures the optimal design and operation of the trial and the widest impact from its results.

Using an existing medicine for a different purpose offers a highly cost-effective approach for treatment that can be implemented and sustained internationally.

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The information about "BETTER-B" are provided by the European Opendata Portal: CORDIS opendata.

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