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BETTER-B SIGNED

BETTER TREATMENTS FOR BREATHLESSNESS IN PALLIATIVE AND END OF LIFE CARE

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BETTER-B project word cloud

Explore the words cloud of the BETTER-B project. It provides you a very rough idea of what is the project "BETTER-B" about.

health    survey    ensures    friends    caregivers    physical    lung    324    accessible    symptom    patients    clinical    wellbeing    trial    18    suggest    offers    treatment    placebo    obstructive    tests    persists    pulmonary    needing    distresses    antidepressant    double    blind    time    medicine    world    emergency    patient    rehabilitation    care    uk    medicines    widest    randomised    statisticians    clinicians    interstitial    carers    reviews    mirtazapine    quality    italy    economists    germany    chronic    optimal    unites    ireland    disciplinary    treating    operation    family    underlying    trialists    guidance    breathlessness    recruits    cb    feasibility    group    alongside    refractory    purpose    internationally    society    respiratory    ild    psychosocial    sustained    geriatric    versus    palliative    disease    frightening    despite    clinician    groups    licenced    conduct    copd    morbidity    community    months    poland    life    reduce    scientists    detrimental    services   

Project "BETTER-B" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 3˙791˙503 €
 EC max contribution 3˙769˙999 € (99%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 1˙395˙122.00
2    UNIVERSITY OF LEEDS UK (LEEDS) participant 669˙111.00
3    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 476˙203.00
4    AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA IT (REGGIO EMILIA) participant 283˙960.00
5    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 230˙812.00
6    KLINIKUM DER UNIVERSITAET ZU KOELN DE (KOELN) participant 170˙383.00
7    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) participant 109˙671.00
8    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) participant 106˙095.00
9    GDANSKI UNIWERSYTET MEDYCZNY PL (GDANSK) participant 97˙612.00
10    UNIVERSITA CATTOLICA DEL SACRO CUORE IT (MILANO) participant 88˙987.00
11    UNIWERSYTET MIKOLAJA KOPERNIKA W TORUNIU PL (TORUN) participant 76˙290.00
12    EUROPEAN RESPIRATORY SOCIETY CH (LAUSANNE) participant 65˙750.00
13    UNIVERSITY OF TECHNOLOGY SYDNEY AU (SYDNEY) participant 0.00

Map

 Project objective

The BETTER-B consortium tests whether mirtazapine, currently used as an antidepressant, is an effective treatment to reduce chronic or refractory breathlessness (CB) in patients with advanced chronic obstructive pulmonary or interstitial lung disease (COPD or ILD) needing palliative care or at the end of life.

Our focus is on breathlessness that persists despite optimal treatment of the underlying condition. This widespread and frightening symptom has a major detrimental impact on patients’ quality of life and distresses their family, friends and carers. It is associated with physical and psychosocial morbidity and results in high use of health care services, including emergency care.

There are no licenced medicines for CB in the world. It is a major challenge to clinical management, care quality and patient wellbeing. We have completed a feasibility trial in 60 patients, reviews and case studies that suggest mirtazapine is a promising treatment.

To assess if mirtazapine is effective, we conduct a randomised double blind clinical trial of mirtazapine versus placebo in patients with CB and COPD or ILD. The trial recruits 324 patients over 18 months across respiratory, palliative care and community services in Poland, Ireland, Italy, Germany and the UK. We study the effects of treatment over time on patients, their family or caregivers and care costs. We survey clinicians and produce accessible European guidance on treating CB.

The consortium unites a unique multi-disciplinary group of clinician scientists from respiratory, palliative, geriatric and rehabilitation fields, alongside statisticians, trialists, health economists, health care researchers, patient and consumer groups and a European Society. This ensures the optimal design and operation of the trial and the widest impact from its results.

Using an existing medicine for a different purpose offers a highly cost-effective approach for treatment that can be implemented and sustained internationally.

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The information about "BETTER-B" are provided by the European Opendata Portal: CORDIS opendata.

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