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NoMePaCa SIGNED

Novel Metabolic Pathways in Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NoMePaCa" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙989˙103 €
 EC max contribution 1˙989˙103 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 1˙989˙103.00

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 Project objective

Metabolic adaptations in central carbon metabolism play a key role in cancer. Yet, the success of therapeutic interventions in major pathways has been limited, although some of the changes have been known to exist for almost 100 years.

Biochemical textbooks present intermediary metabolism as something canonical, and the molecular identity of most enzymes required for the production of known intermediary metabolites is indeed known. Yet, the function of many putative enzymes is still unknown, indicating that novel metabolic pathways containing so far unknown metabolites exist.

We have recently discovered a novel metabolic pathway containing two metabolites that have never been described before. Preliminary data indicate that this pathway might play an important role in a group of cancers sharing specific mutations. Furthermore, genetic inactivation of a component of this pathway in mice is compatible with normal development, indicating that pharmacological inhibition should be well tolerated.

In the present project, we will use a multi-dimensional approach combining biochemical, genetic and pharmacological techniques, to identify missing components of this metabolic pathway and assess its role in cellular metabolism and cancer development. In the process of this, we will develop tools that will allow us to test whether this pathway can be targeted in vivo. Thus, our work will lead to the description of a novel metabolic pathway, should reveal novel regulatory circuits and might open novel therapeutic avenues in cancer and beyond.

 Publications

year authors and title journal last update
List of publications.
2019 Alexandre Y. Marbaix, Georges Chehade, Gaëtane Noël, Pierre Morsomme, Didier Vertommen, Guido T. Bommer, Emile Van Schaftingen
Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P)+
published pages: 3033-3052, ISSN: 0264-6021, DOI: 10.1042/bcj20190602
Biochemical Journal 476/20 2020-03-23
2018 Elsa Wiame, Gaëlle Tahay, Donatienne Tyteca, Didier Vertommen, Vincent Stroobant, Guido T. Bommer, Emile Van Schaftingen
NAT6 acetylates the N‐terminus of different forms of actin
published pages: 3299-3316, ISSN: 1742-464X, DOI: 10.1111/febs.14605
The FEBS Journal 285/17 2020-03-23
2019 Maria Veiga-da-Cunha, Nathalie Chevalier, Xavier Stephenne, Jean-Philippe Defour, Nicole Paczia, Alina Ferster, Younes Achouri, Joseph P. Dewulf, Carole L. Linster, Guido T. Bommer, Emile Van Schaftingen
Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency
published pages: 1241-1250, ISSN: 0027-8424, DOI: 10.1073/pnas.1816143116
Proceedings of the National Academy of Sciences 116/4 2020-03-23
2019 Guido T. Bommer, Emile Van Schaftingen, Maria Veiga-da-Cunha
Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis
published pages: , ISSN: 0968-0004, DOI: 10.1016/j.tibs.2019.07.004
Trends in Biochemical Sciences 2020-03-23
2019 Joseph P. Dewulf, Isabelle Gerin, Mark H. Rider, Maria Veiga-da-Cunha, Emile Van Schaftingen, Guido T. Bommer
The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA
published pages: 2427-2447, ISSN: 0264-6021, DOI: 10.1042/bcj20190500
Biochemical Journal 476/16 2020-03-23
2019 Maria Veiga‐da‐Cunha, Emile Van Schaftingen, Guido T. Bommer
Inborn errors of metabolite repair
published pages: , ISSN: 0141-8955, DOI: 10.1002/jimd.12187
Journal of Inherited Metabolic Disease 2020-03-23
2019 Isabelle Gerin, Marina Bury, Francesca Baldin, Julie Graff, Emile Van Schaftingen, Guido T. Bommer
Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines
published pages: 629-643, ISSN: 0264-6021, DOI: 10.1042/bcj20180435
Biochemical Journal 476/4 2020-03-23

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